DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG30116 and Nwd2

DIOPT Version :9

Sequence 1:NP_725799.1 Gene:CG30116 / 37126 FlyBaseID:FBgn0028496 Length:1922 Species:Drosophila melanogaster
Sequence 2:XP_038948680.1 Gene:Nwd2 / 289633 RGDID:1563065 Length:1742 Species:Rattus norvegicus


Alignment Length:1959 Identity:364/1959 - (18%)
Similarity:695/1959 - (35%) Gaps:546/1959 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 TRLPKPLL-----IKIYVASLKQEFNQERRMLLELVGPELQSL-YDDRQIELEFVDMHFGTGDLE 79
            |.||..|:     :::::::..::...||:.|.|.|.|:|:.. .::..:|.:.:|:::|     
  Rat    28 TALPSHLVPAGRSVRVFISANPEDTGAERQALRETVYPKLREFCRENYGLEFQVIDLYWG----- 87

  Fly    80 VHQLERD-PYLIHDYLHEIDTCHAHTKSVFFMVLVGDGIGRQLLPTKIDEDIFSAVLADQQTSAD 143
            |.:.|.| |.|....:..::.|...:....|:.|:|:..|...:|.:::...|..:| |....|.
  Rat    88 VEEDEWDSPELQKMRMKLLEECLKSSAGPCFVGLLGEKYGNIRIPGQVEASEFEMIL-DAAVEAK 151

  Fly   144 HEAMLVK-WYERD---------------------------------------ASQTQRQLKQDYR 168
            .|..|:: ||.||                                       :.:.:...|...:
  Rat   152 LETKLLEDWYCRDENSVPAAYYLRPRLEVPRTNKNSTQPSATGEHERPWQEISDEIKTIFKAATK 216

  Fly   169 LMNVDAWLAESQRMQ---SFLEQAFQSLLQGSGASGRSPDFMER-VQLLRR-TQIER-----EVS 223
            |::....:..||..:   |.:|..|...|     ..::|.|::: |..:|: ..|||     |:.
  Rat   217 LLHEQGKMKLSQAKRYLFSAIEDEFDFAL-----GKQTPAFLKKCVCYIRKIANIERFVKIPEMG 276

  Fly   224 QAMAL--TSEKILAVFRERAAQCSKGDVEAAERLRKIKDELTMNLSTDNHTTLVVPGSAASEAID 286
            :.|.:  |..:|:.            |.||.|:|.|::||....:...::..:....:.....:.
  Rat   277 KYMDITGTDPRIIR------------DPEAQEKLIKLRDEFIPTIVASSNLRVYTSVTHCDMKLG 329

  Fly   287 PDNEDHESYL----SKFKNKVTDKLRLLIEAHITNDPDVI-------KGRKKTVQEIFHEHATHL 340
            ...|....|:    .:|...:.|.::..::.:...:.|.:       ....||....:......|
  Rat   330 YSQEIENHYIEGLGKQFYEDMIDIIQATVQQNFDTETDTLYDEILQHSSLCKTYASFYEYKCESL 394

  Fly   341 RILREHTDSDALVESRVPQQLRQNLMANFRNGSRHA-PYFLCGADGSGKSAILCHLYGQVGSWFG 404
            .||.::.         :|.:            :.|. |..:.|...:||:.:|..:..:...|  
  Rat   395 NILHKYI---------LPSK------------TGHINPLIVYGGPCTGKTLLLAEVAKKAYGW-- 436

  Fly   405 STRVHR----------VIRFAKATPRSAYNLELLRVICQQISIIFN-IPEGYLPKDASFDPLYIN 458
               :|.          ::||...|..|.....||..:|:|:::.:. :.:.:..|......|:||
  Rat   437 ---LHEDTGPDSDPVVIVRFLGTTDMSIDLRTLLLSVCEQLAVNYRCLVQSFPKKIHDLRDLFIN 498

  Fly   459 TWFQNLLRRVEDMGNDVLFLFIDDLHLLNPLDCDIVTALSWLPTSLPWNVQIICSSTTP-----V 518
            ...::.|:|       .|.:..|.|..|:  :.|....|.|||..||..|:||. ||.|     :
  Rat   499 LLNESSLQR-------PLVIIFDALEQLS--ETDEARKLWWLPAHLPRFVRIIL-STLPNKHGIL 553

  Fly   519 EQLKFTPMQRDRF------------KSIEYQF-----------DLNMGDYATKLKIP-------- 552
            ::|:....:.|.:            :.:::|.           .:.:.:..:|..:|        
  Rat   554 QKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRVKRKVTSGQQIYVNNAFSKCTLPMFVNLTFR 618

  Fly   553 --------------PQCIPGDVSFALYVEQQFDQLERHYGRQAVGDLASYITCSEYGLSETELLE 603
                          ..|:....|    :||.|..||:..|::.|.....|||.::.||||.||.:
  Rat   619 EVRHWRSHKDVNESSLCVTVHES----IEQLFWSLEKKCGQKLVSRALGYITMAKMGLSEMELED 679

  Fly   604 LL-MPTDDPESLIE-TKNGHFSFATFKKIHR-EMDLLLLLHDKIMSGKVLIQWRHNYCASVAKRR 665
            :| :.......||| |:..:.....:..|.| :..|...|.::.:....|:.|.:.:...:|::.
  Rat   680 VLALDNSVMNELIENTRPSNPLRVPYLYIARLKEGLNGYLIERHVKNVTLLVWANRHLQLIAQKL 744

  Fly   666 YM-DVQRTRSLHCELANLFF---------------PQDEDESTLENESNRSESKSVISLKDRDRE 714
            |: :....|.:|..||:.|.               |.......|||.|...|.|..|.....||:
  Rat   745 YLQEDSNLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLENRSLLEEEKHFIEQASFDRQ 809

  Fly   715 KDSLSAVSAVSAGRKSSSTHHNDDTSTFY-NPIAADVSY-SMRHVEESWHHLMRSDDTTRFKQIA 777
            ..                    |....|. ||:..|:.: :.|.:.|..:||.|...|.......
  Rat   810 AP--------------------DQPWVFQCNPLEPDIFFVNHRKMSELLYHLTRCGKTDDLLYGI 854

  Fly   778 VCNFDFLLAAVQTVSISYLRCLIEHVRCYILDRDIELIYYTIRKSSDVLTRDPMQLGSQLISWLR 842
            :.||.:|...::......:...||....|..:::::.:..|:|...:.:...|..|.::|...|.
  Rat   855 IMNFSWLYTMIKIGQFDKVLADIELAYNYSQEKELKFLASTLRGIRNKVITFPGSLSAELQQRLL 919

  Fly   843 PISEHDDDDNSLLSMTVRSATAWCDGYAVPLLVPL-----TGWLPAPLPSQIRTMTVSGTGCIRA 902
            |:.........||....:....:|.      :|||     ..:.|..||                
  Rat   920 PVVSSLPKLRHLLLECDKDGPKYCS------IVPLHSSMDVTYSPERLP---------------- 962

  Fly   903 VWLAPSKQH------------LILATSSGDVQQWHIMSNSLDHIFKGHTAAVTCLL-VAPQSDSE 954
              ||.|..|            ::.|..:|.:..|.:.:..|   .:..|.|.:.:| :...||.:
  Rat   963 --LASSHLHVTEILPTCNPSTVLTALENGSISTWDVETRQL---LRQITTAQSVILGMKLTSDEK 1022

  Fly   955 LLLTGSEDATVLVW-HVG---LRERRAHIKNAH--TAP--ITGVAAGANNTLI-ISSSEDASIAI 1010
            .|:..:.:.|:|:: :|.   |.|  ..||...  ::|  |.|.....|:.|. :.:|:|  :.:
  Rat  1023 YLVVATTNNTLLIYDNVNSCLLSE--VEIKGTKHGSSPTYINGFTLSINHALAWLEASKD--VTV 1083

  Fly  1011 TDLASG----------------------------KLRHRITHHRGPVSGIVVAGACDVL--ISGG 1045
            .||..|                            .|.:....|.|  ||..:   |.|.  .|||
  Rat  1084 IDLLYGWPLYQFHCWYEVTCVQCSLDGVYAFCGQYLNNTTIFHLG--SGEKI---CTVTSEFSGG 1143

  Fly  1046 L------------------DRTICVWDLDNFTLLNTMQMT---------SAVLRIDISWNSVFLL 1083
            .                  :.::.||:.::   :::.|:|         |.|:.|::|.:...:|
  Rat  1144 FVKFLLILDTAQEMVMIDSEGSLSVWNTED---ISSPQLTEDFDCRKEDSEVVSIELSEDQSAIL 1205

  Fly  1084 ALCEDNALYVRTLATG--KELHTLKG-HKSKIRSISIGKDSQRCVVGCDDTRALIY-DMHAGKLV 1144
             :|:  ||.:..|.||  |.....:. |..:..|..:.|:....:...::|.|:.: ....|:.:
  Rat  1206 -ICK--ALSIELLDTGMWKVAEKFRARHNERFISAVLSKNGDCIIATMENTPAVFFWRRDTGQCM 1267

  Fly  1145 RSLPPNPGPVTAVHAMDNDDFLVTVGGNKITFYSFRNEELYVNPYSRHPRRKRSLKRHAQAQRSP 1209
            .||....|.:..:....:.:.|:::                                        
  Rat  1268 ASLKEISGTIVKLVKSSHHNMLLSL---------------------------------------- 1292

  Fly  1210 STTLPPITCFDLSRDSQQMAIASGRHVHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSE 1274
             :|...::.:|:.      .|.:..::.  :...|            :..|.....||.:.:...
  Rat  1293 -STSGVLSIWDID------IITAMSNID--KTGKP------------IQSLVLPARGEIIYSLDG 1336

  Fly  1275 DRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNLLQTIQGP-Y 1338
            ...||.||.:.|.|...|| |...|...|:......::::|..|...||...||..|..|.|. .
  Rat  1337 SDCVHKWNFSSGFIEAVFK-HEGIVEHCVLTSAGDIMVTSDDKSSQYVWHTSSGENLFRINGQRI 1400

  Fly  1339 KSLSVTNNMRFAVSTNGDNTLKIWSLTQEDEKYSVSHSDEITCFEISADSVHI-ISGSRDMSLKV 1402
            ..|.:|:|.:|.||...:|..::|.|.......::..:.: ..|..||::..: ::.|:.:::.:
  Rat  1401 SQLLITHNDQFVVSLCEENASRVWRLATGHRVCNILTTLQ-NAFITSANTFVVGMTKSKVLAVSL 1464

  Fly  1403 WQATGGKLSQVLVGHSDAVT---------CVAVSVTNKTQVLSGSKDMNLILWDLLTGE----EV 1454
            |  ||....:...  .|.:|         |..:.|     .::.::.:|  ||. ||.|    .|
  Rat  1465 W--TGSITKKFCC--EDGITIVNFKLIPDCPDIIV-----FITSAETVN--LWS-LTDEVICRRV 1517

  Fly  1455 HTLAGHLGPVIGVKVSADGSTAVSGSDDKTL-----------------IVWE---TKRGLALTSL 1499
            ...:..|..:...::|.:|...:....|:.:                 ::|.   ::.|..|   
  Rat  1518 QLPSNFLKNLEDFEISPNGKLGIISRGDENINVLDLHSGKLRVVHASGVIWRQRLSRDGRYL--- 1579

  Fly  1500 QMHVPFTHFDISLE----VSRVLVQLVDSYNLPVICLHNTPAQYVKLPTYSGPSKDVEDLRPQGP 1560
             :::.|.:.:...|    .|.::::|.|..|:....|:.|       ||:...|           
  Rat  1580 -VYICFQNGEEEEENDTVSSLIVMRLADGKNIGACSLYKT-------PTFLALS----------- 1625

  Fly  1561 KRQMKRLLKKEVSLDTYTWQKKYGHLTSSVMMAQVDERLKRRFSVSASMEEISKIAETKTGASQA 1625
                :|.|...|..|.       |.:....::.:||..||.:.:.|.|.:..|.  .|:|...::
  Rat  1626 ----QRHLNIIVGFDD-------GSIGIYTVVDRVDAALKIKIATSNSRQIFSN--ATQTSRPKS 1677

  Fly  1626 NLGPEQAALAQSQHFD-QLEALWN-------KRSP-------------PRRRHNAGLSRQTSLVE 1669
            |          |..|. .::.||.       :.||             |.::||:...|..:.:|
  Rat  1678 N----------SYSFKVSVDCLWRESTEVFARDSPITVSDSSESNEATPSKKHNSCYDRVCAALE 1732

  Fly  1670 DRLESSDDD 1678
            .|..|...|
  Rat  1733 SRSHSYTSD 1741

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30116NP_725799.1 AAA_16 359..505 CDD:289934 31/157 (20%)
WD40 repeat 901..937 CDD:293791 8/47 (17%)
WD40 933..1282 CDD:238121 68/419 (16%)
WD40 repeat 942..982 CDD:293791 11/44 (25%)
WD40 repeat 988..1024 CDD:293791 9/64 (14%)
WD40 1022..1484 CDD:225201 93/509 (18%)
WD40 repeat 1029..1064 CDD:293791 9/54 (17%)
WD40 repeat 1071..1106 CDD:293791 10/36 (28%)
WD40 repeat 1112..1147 CDD:293791 5/35 (14%)
WD40 repeat 1216..1252 CDD:293791 3/35 (9%)
WD40 1248..1502 CDD:238121 57/288 (20%)
WD40 repeat 1258..1294 CDD:293791 10/35 (29%)
WD40 repeat 1299..1335 CDD:293791 9/35 (26%)
WD40 repeat 1340..1374 CDD:293791 9/33 (27%)
WD40 repeat 1379..1415 CDD:293791 7/36 (19%)
WD40 repeat 1421..1458 CDD:293791 10/49 (20%)
WD40 repeat 1464..1488 CDD:293791 3/40 (8%)
Nwd2XP_038948680.1 AAA_16 394..523 CDD:404141 30/163 (18%)
WD40 <922..1207 CDD:225201 59/324 (18%)
WD40 repeat 1013..1063 CDD:293791 13/51 (25%)
WD40 repeat 1068..1095 CDD:293791 7/28 (25%)
WD40 1100..1435 CDD:225201 72/407 (18%)
WD40 repeat 1102..1137 CDD:293791 6/39 (15%)
WD40 repeat 1145..1184 CDD:293791 4/41 (10%)
WD40 repeat 1278..1324 CDD:293791 6/106 (6%)
WD40 repeat 1361..1393 CDD:293791 7/31 (23%)
WD40 repeat 1444..1469 CDD:293791 6/26 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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