DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG30116 and NWD1

DIOPT Version :9

Sequence 1:NP_725799.1 Gene:CG30116 / 37126 FlyBaseID:FBgn0028496 Length:1922 Species:Drosophila melanogaster
Sequence 2:XP_011526231.1 Gene:NWD1 / 284434 HGNCID:27619 Length:1564 Species:Homo sapiens


Alignment Length:1794 Identity:391/1794 - (21%)
Similarity:620/1794 - (34%) Gaps:591/1794 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 EFVDMHFGTGDLEVHQLERDPYLIHDY-LHEIDTCHAHTKSVFFMVLVGDGIGRQLLPTKIDEDI 130
            |.||:.:|     :..:|...:|..:. |.|:|.|...:....|:.|:||..|..|:|::|||..
Human    27 EVVDLRWG-----IRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKE 86

  Fly   131 FSAVLADQQTSADHEAMLV-KWYERDASQTQRQLKQDYRLMNVDAWLA-ESQRMQSFLEQAFQSL 193
            :. ||.|..|:...:..|| ::::||    :......|.|.......| |.:      |....|:
Human    87 WE-VLRDHLTARPSDLELVARYFQRD----ENAFPPTYVLQAPGTGEACEPE------EATLTSV 140

  Fly   194 LQGSGASGRSPDFM--ERVQLLRRTQIEREVSQAMALTSEKILAVFRERAAQCSKGDVEAAER-- 254
            |:......|....:  |:.|...|:.||.|:.::: |:||.     ||:.|.....:::...:  
Human   141 LRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSL-LSSED-----REQGATVFLREIQDLHKHI 199

  Fly   255 -----LRKIK-------DELTMNL--STDNHTTLVVPGSA-------ASEAIDPDNEDHESYLSK 298
                 ||.:.       |....||  |..:|.|.:.||..       :.:.::|.|:.|..||.:
Human   200 LEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKE 264

  Fly   299 F--------KNKVTDKLRLL-------------IEAHITNDPDVIK---GRKKTVQEIFHEHATH 339
            .        .::|..:||.|             |..|:....:||:   ||    ||:.      
Human   265 LGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCGR----QELL------ 319

  Fly   340 LRILREHTDSDALVESRVPQQLRQNLMANFRNGSRHAPYFLCGADGSGKSAILCHLYGQVGSWFG 404
                           :|:.||||.:      :..:|.|..|.|..|.||:|::|.|..|:....|
Human   320 ---------------ARLGQQLRHD------DSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLG 363

  Fly   405 STRVHRVIRFAKATPRSAYNLELLRVICQQISIIFNIPEGYLPKDASFDP-LYINTWFQNLLRRV 468
            ...| .|:|....:..|:....||:.||.|:.:.:.:|   ||.....|. ..:..:|..||..|
Human   364 HKTV-TVLRLLGTSQMSSDARGLLKSICFQVCLAYGLP---LPPAQVLDAHTRVVQFFHTLLHTV 424

  Fly   469 EDMGNDVLFLFIDDLHLLNPLDCDIV---TALSWLPTSLPWNVQII---CSSTTPV-EQLKFTPM 526
            .....:.|.|.:|.:.     |.|.|   ..:.|||.:.|..|.:|   ||....| :.|:...:
Human   425 SCRNFESLVLLLDAMD-----DLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLL 484

  Fly   527 QRDRFKSIEYQFDLNMGDYATKLKIP------------------PQC-IPGDV-----------S 561
            ..:.:..:: ....|.|....:|.:.                  |:| .||.:           |
Human   485 DPEAYWEVK-PLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWAS 548

  Fly   562 FALYV----------EQQFDQLERHYGRQAVGDLASYITCSEYGLSETELLELLMPTDD------ 610
            |.:.|          .|...:||:.:|:..|..:..||..|.:||||.||.::|...|:      
Human   549 FTVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVY 613

  Fly   611 ----PES--LIETKNGHFSFATFKKIHREMDLLLLLHDKIMSGKVLIQWRHNYCASVAKRRYMDV 669
                |.|  |:.       |.....:....||...|..:.:.|..|:...|.....|.:.||:..
Human   614 RDWTPPSKELLR-------FPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSG 671

  Fly   670 QRTRSLHCELANLFFPQDEDESTLENESNRSESKSVISLK--------DRDREKDSLSAVSAVSA 726
            ......|..||: ||.....:.|          |.:|:|.        ||......|        
Human   672 SERAKRHGVLAD-FFSGTWSQGT----------KKLITLPLVGKPLNLDRKVAPQPL-------- 717

  Fly   727 GRKSSSTHHNDDTSTFYNPIAADVSYSMRHVEESWHHLMRSDDTTRFKQIAVCNFDFLLAAVQTV 791
                          .|.:.:|     ::|.::|..:||:.|......||..:            .
Human   718 --------------WFSHTVA-----NLRKLKELPYHLLHSGRLEELKQEVL------------G 751

  Fly   792 SISYLRCL-----IEHVRCYILDRDIELIYYTIRKSSDVLTRDPMQLGSQLISWLRPISEHDDDD 851
            |:|::.|.     ||.    :|| |.:|....:......|.|:.:||       .||..|....:
Human   752 SMSWISCRGISGGIED----LLD-DFDLCAPHLDSPEVGLVREALQL-------CRPAVELRGME 804

  Fly   852 NSLL-------------------SMTVRSATAWCDGYAVPLLVPLTGWLPAPLPSQIRTMTVSGT 897
            .|||                   ....:.|.:|....|.|:||||.|:|..|            .
Human   805 RSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQPP------------G 857

  Fly   898 GCIRAVWLAPSKQHLILATSSGDVQQWHIMSNSLDHIFKGHTAAVTCLLVAPQSDSELLLTGSED 962
            |.:|             ||.||              ..||.||      :|...:.:||:.|::|
Human   858 GPLR-------------ATLSG--------------CHKGITA------MAWGVEEKLLVIGTQD 889

  Fly   963 ATVLVW-----HVGLRERRAHIKNAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRI 1022
            ..:.||     ||      .|:...||..:..|...|..||..|:|:|.::.:.:|.||:.:..|
Human   890 GIMAVWDMEEQHV------IHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTI 948

  Fly  1023 TH--HRGP----VSGIVVAGACDVLISGGLDRTICVWDLDN----FTLLNTMQ---MTSAVLRID 1074
            ..  .:.|    :..:.|..|..|:.|....: |..|:|:.    |.:|....   |..|||.  
Human   949 WDGGSKNPAEPQIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFHILGDASDPWMCMAVLA-- 1010

  Fly  1075 ISWNSVFLLALCEDNALYVRTLATGKELHTLKG--HKSKIRSISIGKDSQRCVVGCDDTRALIYD 1137
               :...||.:..|..:.:.:.||||    |:|  |.|     ||.:::..|.|..         
Human  1011 ---SQATLLTVSRDGVVSLWSSATGK----LQGKQHMS-----SIKEETPTCAVSV--------- 1054

  Fly  1138 MHAGKLVRSLPPNPGPVTAVHAMDNDDFLVTVGGNKITFYSFRNEELYVNPYSRHPRRKRSLKRH 1202
            ...||||...  :.|.::          ||:..|:::.      |:|        |...|.|.  
Human  1055 QKQGKLVTGF--SNGSIS----------LVSSKGDRLL------EKL--------PDAVRFLV-- 1091

  Fly  1203 AQAQRSPSTTLPPITCFDLSRDSQQMAIASGRHVHLMRINTPEYQ----CTLEGHTAGVSCLKFA 1263
                              :|.|...:|...||.|.:...::..::    ..|| |...|....|.
Human  1092 ------------------VSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLE-HEDMVETAVFG 1137

  Fly  1264 PNGEFLATGSEDRLVHIWNLA-LGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVW---M 1324
            .....:.|||.|.|:.:|:|: .|.:.:..:|..|| |.::....:|...::.:.|...||   .
Human  1138 TENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAP-VSLLARGGALVASASPQSSSFKVWDLSD 1201

  Fly  1325 AHSGNLLQTIQGPYKSLSVTNNMRFAVSTNGD----------NTLKIWSLTQEDEKYSVSHSDEI 1379
            ||...    :..|:    :......|||.||.          |.:.||.|.:.:|:.|:..|.||
Human  1202 AHRSR----VPAPF----LDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEI 1258

  Fly  1380 TCFEI------------------------------------------------------------ 1384
            .|.|:                                                            
Human  1259 RCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVL 1323

  Fly  1385 -----SADSVHIISGSR------------------DMSLKVWQATGGKL---------SQVLVGH 1417
                 |.|...:|.|.|                  |..: |:..|.|.|         :..|..|
Human  1324 VLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRV-VYSMTNGDLFLYECATSKAFPLETH 1387

  Fly  1418 SDAVTCVAVSVTNKTQ-VLSGSKDMNLILWDLLTGE---EVHTLAGHLGPVIGVKVSADGSTAVS 1478
            ...|.||.||  :|.| |:|||:|..|.||||...:   |:...:.:...|.....|.|......
Human  1388 RSRVACVEVS--HKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYV 1450

  Fly  1479 GSDDKTLIVWETKRGLALTSLQMHVPFTHFDISLEVSRVLVQLVDSYNLPVICLHNTPAQYVKLP 1543
            |..|::::||....|..||     |.|.|    ..|:|:                        :|
Human  1451 GLKDRSILVWSVLDGTLLT-----VQFVH----AVVNRI------------------------IP 1482

  Fly  1544 TYSG---PSKDVEDLR-----------PQGPKRQMKRLL 1568
            |.||   |::....:|           ||.|.:..|:.:
Human  1483 TTSGFIAPTRHGYLIRENFQCLSAKASPQDPLKNFKKAM 1521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30116NP_725799.1 AAA_16 359..505 CDD:289934 42/149 (28%)
WD40 repeat 901..937 CDD:293791 5/35 (14%)
WD40 933..1282 CDD:238121 85/372 (23%)
WD40 repeat 942..982 CDD:293791 10/44 (23%)
WD40 repeat 988..1024 CDD:293791 11/35 (31%)
WD40 1022..1484 CDD:225201 124/590 (21%)
WD40 repeat 1029..1064 CDD:293791 9/38 (24%)
WD40 repeat 1071..1106 CDD:293791 8/34 (24%)
WD40 repeat 1112..1147 CDD:293791 8/34 (24%)
WD40 repeat 1216..1252 CDD:293791 7/39 (18%)
WD40 1248..1502 CDD:238121 80/363 (22%)
WD40 repeat 1258..1294 CDD:293791 9/36 (25%)
WD40 repeat 1299..1335 CDD:293791 7/38 (18%)
WD40 repeat 1340..1374 CDD:293791 11/43 (26%)
WD40 repeat 1379..1415 CDD:293791 13/127 (10%)
WD40 repeat 1421..1458 CDD:293791 18/40 (45%)
WD40 repeat 1464..1488 CDD:293791 5/23 (22%)
NWD1XP_011526231.1 AAA 314..>399 CDD:99707 30/116 (26%)
WD40 860..1156 CDD:295369 90/405 (22%)
WD40 repeat 871..908 CDD:293791 12/48 (25%)
WD40 906..1286 CDD:225201 101/459 (22%)
WD40 repeat 914..952 CDD:293791 11/37 (30%)
WD40 repeat 961..996 CDD:293791 8/35 (23%)
WD40 repeat 1004..1041 CDD:293791 14/45 (31%)
WD40 repeat 1087..1124 CDD:293791 8/56 (14%)
WD40 1127..1461 CDD:295369 74/345 (21%)
WD40 repeat 1131..1155 CDD:293791 7/23 (30%)
WD40 repeat 1259..1297 CDD:293791 2/37 (5%)
WD40 repeat 1302..1337 CDD:293791 2/34 (6%)
WD40 repeat 1352..1383 CDD:293791 5/31 (16%)
WD40 repeat 1391..1429 CDD:293791 18/39 (46%)
WD40 repeat 1436..1462 CDD:293791 7/25 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49333
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
32.880

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