DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30116 and WDR27

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_872358.4	Gene:	WDR27 / 253769	HGNCID:	21248	Length:	895	Species:	Homo sapiens

Alignment Length:	830	Identity:	157/830 - (18%)
Similarity:	276/830 - (33%)	Gaps:	261/830 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   895 SGTGCIRAV----WLAPSKQ---HLILATSSGD---------VQQWHIMSNSLDH---IFKGHTA 940
            |..||:..:    :|..||:   |:.||.|..|         :..|:....|  |   |.:||..
Human    10 SNGGCLSDIVIEKYLVESKESVSHVQLACSMQDCAFPLDGTELCIWNTKDPS--HQLLILRGHHQ 72

  Fly   941 AVTCLLVAPQSDSELLLTGSEDATVLVWHVG-LRER-------RAHIKNA--------------H 983
            .:|.:....:.:..|:.:.|.| .|::|::. .||:       |..:..:              |
Human    73 PITAMAFGNKVNPLLICSASLD-YVIMWNLDECREKVLQGLVPRGTVMGSLLGKVLCLQLSLDDH 136

  Fly   984 TAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRI-----TH--------------HRGPV 1029
               :..|.|| |...::...:..|:...:......||::     .|              |.|||
Human   137 ---VVAVCAG-NKIFMLDIEQRFSVTYIERPDVNNRHKVPPPTFLHTFSQTQAVRAELQGHLGPV 197

  Fly  1030 SGIVV----AGACDVLISGGLDRTICVWDLDNFTLLNTMQMTSA--VLRIDISWNSVFLLALCED 1088
            :.:..    ||   .|||...||...|||....:|:.:..:.||  :|.:.|...|..|:..|.|
Human   198 TAVEFCPWRAG---TLISASEDRGFKVWDHCTGSLIYSSSVLSAYPLLSLFIDAESRQLVTGCAD 259

  Fly  1089 NALYVRTLATG------------KELHTL-----------KGHKSKIRSIS-IGKDSQ------- 1122
            ..|::.:|..|            |:..|.           :..:|::.|.| :||..|
Human   260 GQLWIFSLMDGHHYRRVARVDLRKKTETFSTRRVKSGLCSQPEESQLPSTSALGKGEQVEVTFPV 324

  Fly  1123 ------------RCVVGC---DDTRALIYDMHAGKLVRSLPPNPGPVTAVHAMDNDDFLVTVGGN 1172
                        ....||   ::||.:......|..|.:| .|.....|::..|.....:.:.|:
Human   325 LRLAPCDLSLIPNSACGCLSSENTRCVWIGSSVGLFVFNL-ANLEVEAALYYKDFQSLSILLAGS 388

  Fly  1173 ----------KI-----TFYSFRNEELYVNP---------------------------------- 1188
                      |:     :.:..:...|.:||
Human   389 CALRNRTADQKVLCLLASLFGGKIAVLEINPAALVRAQQCPSMGQSLSVPASSCVLPTSPLYLGI 453

  Fly  1189 --------------YSRHPRRKRSLKRHAQAQRSPSTTLPPITCFDLSRDSQQMAIASGRH---- 1235
                          .:|:..:.:.|..|::.:.|...:.|.:|.|....:.:.....|.|.
Human   454 AKEKSTKAASEQRRAARNVMKDQRLVFHSKVRSSGYASAPHVTMFSPKTNIKSEGKGSSRSRSSC 518

  Fly  1236 ------VHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGEICNSFKG 1294
                  |.......|..|.........|.|::::.:|::||.|..:.|:.:::.:|......|.|
Human   519 AREAYPVECAVPTKPGPQVAAAPTCTRVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSG 583

  Fly  1295 HTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNL------------LQTIQ------------ 1335
            |...|..|....|...::|..||..|.:|.|....|            :|:.|
Human   584 HDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLGKDMFSKPIQSAQFYYIDAFILLSS 648

  Fly  1336 GPYKSLSVTNNMRFAVSTNGDNTLKIWSLTQEDEKYSVSHSDEITCFEISADSV----------- 1389
            ||...|     :|:.:.|..|          |.::|......::.|...:..:|
Human   649 GPEFQL-----LRYHIDTCKD----------EIKRYKQKSKSKLICRLSTTGAVDMTSLSAVNDF 698

  Fly  1390 --HII-SGSRDMSLKVWQATGGKLSQVLV-GHSDAVTCVAVS-----VTNKTQV----LSGSKDM 1441
              ||: :..|:.:::|:....|..:.|:. .||..|..:..:     .|.:.|.    |:.:...
Human   699 YSHIVLAAGRNRTVEVFDLNAGCSAAVIAEAHSRPVHQICQNKGSSFTTQQPQAYNLFLTTAIGD 763

  Fly  1442 NLILWDLLTGEEVHTLAGH--LGPVIGVKVSADGSTAVSGSDDKTLIVWE 1489
            .:.||||.|........||  .|...|:..|..|..|..|::|:...|:|
Human   764 GMRLWDLRTLRCERHFEGHPTRGYPCGIAFSPCGRFAACGAEDRHAYVYE 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934
		WD40 repeat	901..937	CDD:293791	12/54 (22%)
		WD40	933..1282	CDD:238121	90/517 (17%)
		WD40 repeat	942..982	CDD:293791	9/47 (19%)
		WD40 repeat	988..1024	CDD:293791	7/40 (18%)
		WD40	1022..1484	CDD:225201	121/655 (18%)
		WD40 repeat	1029..1064	CDD:293791	12/38 (32%)
		WD40 repeat	1071..1106	CDD:293791	11/57 (19%)
		WD40 repeat	1112..1147	CDD:293791	11/57 (19%)
		WD40 repeat	1216..1252	CDD:293791	7/45 (16%)
		WD40	1248..1502	CDD:238121	61/292 (21%)
		WD40 repeat	1258..1294	CDD:293791	8/35 (23%)
		WD40 repeat	1299..1335	CDD:293791	11/47 (23%)
		WD40 repeat	1340..1374	CDD:293791	6/33 (18%)
		WD40 repeat	1379..1415	CDD:293791	8/49 (16%)
		WD40 repeat	1421..1458	CDD:293791	9/45 (20%)
		WD40 repeat	1464..1488	CDD:293791	6/23 (26%)
WDR27	NP_872358.4	WD40	15..356	CDD:225201	70/350 (20%)
		WD40 repeat	32..69	CDD:293791	9/38 (24%)
		WD40	<48..266	CDD:295369	48/227 (21%)
		WD40 repeat	74..119	CDD:293791	9/45 (20%)
		WD40 repeat	127..161	CDD:293791	6/37 (16%)
		WD40 repeat	197..230	CDD:293791	11/35 (31%)
		WD40 repeat	241..267	CDD:293791	7/25 (28%)
		WD40	<544..865	CDD:225201	61/285 (21%)
		WD40	545..842	CDD:295369	61/284 (21%)
		WD40 repeat	546..583	CDD:293791	9/36 (25%)
		WD40 repeat	589..660	CDD:293791	15/75 (20%)
		WD40 repeat	678..727	CDD:293791	8/48 (17%)
		WD40 repeat	735..780	CDD:293791	8/44 (18%)
		WD40 repeat	788..824	CDD:293791	8/26 (31%)
		GVQW	847..>881	CDD:290611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7467
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950