DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG30116 and Tep1

DIOPT Version :9

Sequence 1:NP_725799.1 Gene:CG30116 / 37126 FlyBaseID:FBgn0028496 Length:1922 Species:Drosophila melanogaster
Sequence 2:NP_033377.1 Gene:Tep1 / 21745 MGIID:109573 Length:2629 Species:Mus musculus


Alignment Length:1792 Identity:340/1792 - (18%)
Similarity:588/1792 - (32%) Gaps:562/1792 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PIDESVLNALRGVTSAHTRLPKPLLIKIYVASLKQEFNQERRMLLELVGPELQSLYDDRQIELEF 68
            |::|::...|..::....|     .|:::::|..::.:.||.:|:..|.|.||:.....:|.|..
Mouse   888 PLEENIPGPLGPISQHGWR-----NIRLFISSTFRDMHGERDLLMRSVLPALQARVFPHRISLHA 947

  Fly    69 VDMHFGTGDLEVHQLERDPYLIHDYLHEIDTCHAHTK-SVFFMVLVGDGIGRQLLPTKIDEDIFS 132
            :|:.:|..:.|..:           ..:::.|....: |..|:.::|...|  .:|...|     
Mouse   948 IDLRWGITEEETRR-----------NRQLEVCLGEVENSQLFVGILGSRYG--YIPPSYD----- 994

  Fly   133 AVLADQQTSADHEAMLVKW---YERDASQTQRQLKQDYRLMNVDAWLAESQRMQSFLEQAFQSLL 194
                    ..||...  .|   |....|.|:.::.|         :|...||.|    .:.|:|:
Mouse   995 --------LPDHPHF--HWTHEYPSGRSVTEMEVMQ---------FLNRGQRSQ----PSAQALI 1036

  Fly   195 QGSGASGRSPDFMERVQLLRRTQIEREVSQAMALTSE--KILAVFRE---RAAQCSKGDVEAA-- 252
            .     .|.|||:..|....:.....|..:|....||  :.|...:|   |:..|..|.|.|.  
Mouse  1037 Y-----FRDPDFLSSVPDAWKPDFISESEEAAHRVSELKRYLHEQKEVTCRSYSCEWGGVAAGRP 1096

  Fly   253 -----ERLRKIKDELTMNLSTDNHTTLVVPGSAASEAIDPDNED-HESYLSKFKNKVTD-KLRLL 310
                 |...::..:...::....|   :.||:...:......:| .::...:.|...:. :.|||
Mouse  1097 YTGGLEEFGQLVLQDVWSMIQKQH---LQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPARPRLL 1158

  Fly   311 IEAHITNDPDVIKGRKKTVQEIFHEHATHLRILREHTDSDALVESRVPQQLRQNLMANFRNGSRH 375
                           :.|||::...|.                        |.:|:.        
Mouse  1159 ---------------QDTVQQLLLPHG------------------------RLSLVT-------- 1176

  Fly   376 APYFLCGADGSGKSAILCHLYGQVGSWFGSTRVHRV-----------IRFAKATPRSAYNLELLR 429
                  |..|.||:|.|..|...:          :|           ..||.|.|.....|.|||
Mouse  1177 ------GQAGQGKTAFLASLVSAL----------KVPDQPNEPPFVFFHFAAARPDQCLALNLLR 1225

  Fly   430 VIC----QQISIIFNIPEGYLPKDASFDPLYINTWFQNLLRRVEDMGNDVLFLFIDDLHLLNPLD 490
            .:|    |::..:..:|..|...........:..:.|:|      .....|.|.||....|...:
Mouse  1226 RLCTHLRQKLGELSALPSTYRGLVWELQQKLLLKFAQSL------QPAQTLVLIIDGADKLVDRN 1284

  Fly   491 CDIVTALSWLPTSLPWNVQIICSSTTPVEQLKFTPMQRDRFKSIEYQFDLNMGDYATKLKIPPQC 555
            ..:::  .|:|.|||..|.::.|.::.              ..:......:.|.|...|   ...
Mouse  1285 GQLIS--DWIPKSLPRRVHLVLSVSSD--------------SGLGETLQQSQGAYVVAL---GSL 1330

  Fly   556 IPGD------VSFALY----VEQQF-DQLERHYGRQA---------VGDLASYITCSEYGLSETE 600
            :|..      ...|||    .|..| :|:.....:|.         |.|.....|..|.......
Mouse  1331 VPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLR 1395

  Fly   601 LLELLMP--TDDPESLIETKNGH-------------FSFATFKKIHREMDLLLLLHDKIMSGKVL 650
            .|...:|  .....|.:|.::||             .|..|..::|..:...|:|..:..|    
Mouse  1396 TLPATLPLLLQHILSTLEQEHGHDVLPQALTALEVTRSGLTVDQLHAILSTWLILPKETKS---- 1456

  Fly   651 IQWRHNYCAS-------VAKRRYMDVQRTRSLHCELANLFFPQDEDESTLENESNR---SESKSV 705
              |.....||       :....|: ||..|||            ..|..:|....|   |:....
Mouse  1457 --WEEVLAASHSGNPFPLCPFAYL-VQSLRSL------------LGEGPVERPGARLCLSDGPLR 1506

  Fly   706 ISLKDRDREKDSLSAVSAVSAGRKSSSTHHNDDTSTFYN--PIA-ADVSYSMRHVEESWHHLMRS 767
            .::|.|..::..|...:.|........|...|.:.||.:  |.| .|:.|   |:.:|.:|.:.:
Mouse  1507 TTIKRRYGKRLGLEKTAHVLIAAHLWKTCDPDASGTFRSCPPEALKDLPY---HLLQSGNHGLLA 1568

  Fly   768 DDTTRFKQIAVCNFDFLLAAVQTVSISYLRCLIEHVRCYILDR----------DIELIYYTIRKS 822
            :..|....:|.           .:.:..:..|:|....|...:          |:.:.:..:|:.
Mouse  1569 EFLTNLHVVAA-----------YLEVGLVPDLLEAHVLYASSKPEANQKLPAADVAVFHTFLRQQ 1622

  Fly   823 SDVLTRDPMQLGSQLISWLRPISEHDDDDNSLLSMTVRSATAWCDGYAVPLLVPLTGWL--PAPL 885
            :.:||:.|:.|..|..|        ..:::.:..........|.|.:.:.       |:  |..|
Mouse  1623 ASLLTQYPLLLLQQAAS--------QPEESPVCCQAPLLTQRWHDQFTLK-------WINKPQTL 1672

  Fly   886 PSQIRTMTVSGTGCIRAVWLAPSKQHLILATSSGDV--------QQWHIMSNSLDHIFKGHTAAV 942
            ..| ::::::.:....||..:|:.|...:.|:||.:        |:...:.:..|.|..      
Mouse  1673 KGQ-QSLSLTMSSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISS------ 1730

  Fly   943 TCLLVAPQSDSELLLTGSEDATVLVWHVGLRERRAH-----IKNAHTAPITGVAAGANNTLIISS 1002
                .|..||:.|.|| :.|..:.:|.:      .|     ...||...|||.....:..|:.:.
Mouse  1731 ----FAFLSDTALFLT-TFDGHLELWDL------QHGCWVFQTKAHQYQITGCCLSPDRRLLATV 1784

  Fly  1003 SEDASIAITDLASGKLRHRITHHRG-------PVSGIVV----AGACDVLISGGLDRT------- 1049
            .....:.:.|...|:|..:.||.:.       |...:|.    ||:.....:.||..|       
Mouse  1785 CLGGYLKLWDTVRGQLAFQYTHPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLKVTKELGAPG 1849

  Fly  1050 --ICVWDLDNFTLLNTMQMTSAVLRID-----ISWNSVFLLAL------CEDNALYV----RTLA 1097
              :|      ....|......||.|||     .:|.....||.      |....|::    |.|.
Mouse  1850 PSVC------SLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLT 1908

  Fly  1098 TGKE--LHTLKGHKSKIR------------SISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLP 1148
            .|::  .....|...:.|            |:::..|..:..||..:....||.:.:|       
Mouse  1909 AGEDGKAQLWSGFLGRPRGCLGSLPLSPALSVALNPDGDQVAVGYREDGINIYKISSG------- 1966

  Fly  1149 PNPGPV-----TAVHAMDNDDFLVTVGG---NKITFYSFRNEELYVNPYSRHPRRKRSLKRHAQA 1205
             :.||.     .||.|:......|.|.|   ..:..:.|:.:.|:            ||...::.
Mouse  1967 -SQGPQHQELNVAVSALVWLSPSVLVSGAEDGSLHGWMFKGDSLH------------SLWLLSRY 2018

  Fly  1206 QRSPSTTLPPITCFDLSRDSQQMAIAS--------------GRHVHLMRINTPEYQC--TLEGHT 1254
            |:       |:  ..|:...:.||.||              ..|||.:     |..|  .|.||.
Mouse  2019 QK-------PV--LGLAASRELMAAASEDFTVRLWPRQLLTQPHVHAV-----ELPCCAELRGHE 2069

  Fly  1255 AGVSCLKFAPNGEFLATGSEDR--------------LVH-------------------------- 1279
            ..|.|..|:|:|..|||...||              |:|                          
Mouse  2070 GPVCCCSFSPDGGILATAGRDRNLLCWDMKIAQAPLLIHTFSSCHRDWITGCAWTKDNILVSCSS 2134

  Fly  1280 -----IWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVW----------MAHSGN 1329
                 :||...|:....|.||.:.|..||.:.:  .::|..||..|.||          .||||.
Mouse  2135 DGSVGLWNPEAGQQLGQFSGHQSAVSAVVAVEE--HIVSVSRDGTLKVWDHQGVELTSIPAHSGP 2197

  Fly  1330 L----------------------------------------LQTIQ---GPYKSLSVTNNMRFAV 1351
            :                                        ::|:|   ||..:.:.:......:
Mouse  2198 ISQCAAALEPRPGGQPGSELLVVTVGLDGATKLWHPLLVCQIRTLQGHSGPVTAAAASEASGLLL 2262

  Fly  1352 STNGDNTLKIWSLTQE-DEKYSVSHSDEITCFEISADSVHIISGSRDMSLKVWQ-----ATG--- 1407
             |:.|:::::|.:.:| |:.|....|..||....:.|...::||:....|.:||     ||.   
Mouse  2263 -TSDDSSVQLWQIPKEADDSYKPRSSVAITAVAWAPDGSMVVSGNEAGELTLWQQAKAVATAQAP 2326

  Fly  1408 GKLSQVLVGHSDAVTCVAVSVTNKTQVLSGSKDMNLILWDL-------LTGEEVH---TLAGHLG 1462
            |::|. |:.:|          .|...|||.::  |:..|.:       .|...:|   .|....|
Mouse  2327 GRVSH-LIWYS----------ANSFFVLSANE--NVSEWQVGLRKGSTSTSSSLHLKRVLQEDWG 2378

  Fly  1463 PVIGVKVSADGSTAVSGSDDKTLIVWETKRGLALTSL 1499
            .:.|:.::.||.:.:...:|..|:  |.|.|...:|:
Mouse  2379 VLTGLGLAPDGQSLILMKEDVELL--EMKPGSIPSSI 2413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30116NP_725799.1 AAA_16 359..505 CDD:289934 32/160 (20%)
WD40 repeat 901..937 CDD:293791 10/43 (23%)
WD40 933..1282 CDD:238121 91/471 (19%)
WD40 repeat 942..982 CDD:293791 9/44 (20%)
WD40 repeat 988..1024 CDD:293791 6/35 (17%)
WD40 1022..1484 CDD:225201 130/651 (20%)
WD40 repeat 1029..1064 CDD:293791 8/47 (17%)
WD40 repeat 1071..1106 CDD:293791 11/51 (22%)
WD40 repeat 1112..1147 CDD:293791 8/46 (17%)
WD40 repeat 1216..1252 CDD:293791 11/51 (22%)
WD40 1248..1502 CDD:238121 79/371 (21%)
WD40 repeat 1258..1294 CDD:293791 15/80 (19%)
WD40 repeat 1299..1335 CDD:293791 14/85 (16%)
WD40 repeat 1340..1374 CDD:293791 6/34 (18%)
WD40 repeat 1379..1415 CDD:293791 12/43 (28%)
WD40 repeat 1421..1458 CDD:293791 8/46 (17%)
WD40 repeat 1464..1488 CDD:293791 5/23 (22%)
Tep1NP_033377.1 TEP1 N-terminal 1 1..30
TEP1_N 1..29 CDD:283129
TEP1 N-terminal 2 31..60
TEP1_N 31..59 CDD:283129
TEP1 N-terminal 3 61..90
TEP1_N 62..89 CDD:283129
TEP1 N-terminal 4 91..120
TEP1_N 91..119 CDD:283129
TROVE 230..685 CDD:283406
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 386..412
DUF4062 917..1017 CDD:290011 25/127 (20%)
NACHT 1171..1346 CDD:283404 41/223 (18%)
WD 1 1420..1462 7/47 (15%)
WD 2 1681..1720 8/38 (21%)
WD40 repeat 1687..1723 CDD:293791 8/35 (23%)
WD 3 1723..1761 11/54 (20%)
WD40 repeat 1729..1764 CDD:293791 9/51 (18%)
WD40 1763..2182 CDD:238121 95/460 (21%)
WD 4 1764..1803 9/38 (24%)
WD40 repeat 1769..1804 CDD:293791 7/34 (21%)
WD 5 1805..1844 9/38 (24%)
WD40 1806..2198 CDD:225201 90/433 (21%)
WD40 repeat 1811..1847 CDD:293791 7/35 (20%)
WD 6 1847..1886 9/44 (20%)
WD40 repeat 1852..1887 CDD:293791 10/40 (25%)
WD 7 1889..1930 7/40 (18%)
WD40 repeat 1895..1930 CDD:293791 6/34 (18%)
WD 8 1932..1971 8/46 (17%)
WD40 repeat 1937..2066 CDD:293791 31/162 (19%)
WD 9 1974..2013 9/50 (18%)
WD40 1979..2273 CDD:238121 61/322 (19%)
WD40 repeat 1979..2014 CDD:293791 9/46 (20%)
WD 10 2015..2054 7/47 (15%)
WD 11 2067..2106 12/38 (32%)
WD40 repeat 2072..2111 CDD:293791 12/38 (32%)
WD 12 2113..2151 3/37 (8%)
WD40 repeat 2118..2141 CDD:293791 0/22 (0%)
WD 13 2154..2191 11/38 (29%)
WD40 repeat 2159..2190 CDD:293791 9/32 (28%)
WD 14 2193..2241 4/47 (9%)
WD40 repeat 2198..2243 CDD:293791 1/44 (2%)
WD 15 2244..2282 7/38 (18%)
WD40 repeat 2250..2272 CDD:293791 2/22 (9%)
WD 16 2285..2324 11/38 (29%)
WD40 repeat 2290..2322 CDD:293791 8/31 (26%)
WD 17 2326..2362 10/48 (21%)
WD40 repeat 2330..2374 CDD:293791 11/56 (20%)
WD 18 2375..2424 10/41 (24%)
WD40 repeat 2380..2410 CDD:293791 8/31 (26%)
WD40 2408..>2625 CDD:225201 1/6 (17%)
WD40 repeat 2420..2465 CDD:293791
WD 19 2467..2507
WD40 repeat 2472..2495 CDD:293791
WD40 <2534..>2602 CDD:295369
WD 20 2555..2592
WD 21 2594..2628
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4155
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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