DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30116 and rbc-2

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_001368042.1	Gene:	rbc-2 / 190267	WormBaseID:	WBGene00004314	Length:	1373	Species:	Caenorhabditis elegans

Alignment Length:	1111	Identity:	218/1111 - (19%)
Similarity:	385/1111 - (34%)	Gaps:	363/1111 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   942 VTCLLVAPQSDSELLLTGSEDATVLVWHV--GLRERRAHIKNAHTAPITGVAAGAN---NTLIIS 1001
            :..:.|.|  |...::||:|:..:::|.:  ||..::..|  .|:..||.::...|   ||..:|
Worm    30 ICAIRVLP--DGATIITGAENGHIIIWKLAEGLMPKQLMI--GHSQKITAISQTTNTPTNTRFVS 90

  Fly  1002 SSEDASIAITDLASGK--------LRHRI---------THHRGPVSGIVVAGACDVLISGGLDRT 1049
            :|.|..:.:.::..|:        ..||.         .|.|.                   .|.
Worm    91 ASADGRVCLWEIQDGRCIDSTSSIAIHRYIYPYTYKSSRHTRA-------------------TRL 136

  Fly  1050 ICVWDLDNFTLLNTMQMT---SAVLRIDISWNSVF-----------LLALCEDNALYVRTLATGK 1100
            .|:.|..:..:::...:|   |...|::..|.|.|           |:.:.....:.|.||.
Worm   137 FCIGDYSDIQVMDPQDLTVVFSISSRVEPDWISCFTIISHPEKEDQLIGMTLSGMMKVWTLT--- 198

  Fly  1101 ELH------TLKGHKSK------IRSISIGKDSQRCVVGCDDTRALIYDM--------HAGKLVR 1145
            ||.      :|...:||      |||:|....::|.::....|..:|.||        |..::..
Worm   199 ELEKKDPATSLYEDESKRLEIQHIRSVSYICSTRRMLLIIASTCWMIIDMDDLSTVVFHKNEITT 263

  Fly  1146 SLPPNPGPVTAVHAMDNDDFLVTVGGNKITFYSFRNEELYVNPYSRHPRRKRSLKRHAQAQRSPS 1210
            .      ...|.:..|.|.  ||:|        :.:|.::|........:|..
Worm   264 K------RCVAGYLTDLDK--VTIG--------YTDESIHVFQLPIESLQKEG------------ 300

  Fly  1211 TTLPPITCFDLSRDSQQMAIASGRHV-HLMRINTPEYQCTLEG---HTAGVSCL---KFAPNGEF 1268
              :||:             :|:.|.. :......|....|:.|   |:.  |||   :||    |
Worm   301 --VPPV-------------VANNRPTSNYFDQPNPFIVATVNGVQEHSR--SCLNDVQFA----F 344

  Fly  1269 LATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNLLQT 1333
            |...|.:        :|....:|::.....||:           |:.||..:|||     |:...
Worm   345 LPYNSSN--------SLESSSSSYEKRRFSVVR-----------SSRRDGSVLVW-----NMPPF 385

  Fly  1334 IQGPYKSLSVTNNMRFAVS-TNGDNTLKIWSLTQ--EDEKYSVSHSDEITC----------FEIS 1385
            .....|::....|:.|..: |..::...||....  ||....|.:||.:.|          |...
Worm   386 DHQFMKAVPAIRNLPFKFNGTYRESLASIWQTINECEDGSMPVLNSDAVCCSLFVTSQGKLFLGR 450

  Fly  1386 ADSVHIISGSRDMSLKVW------QATGGKLSQVLVGHSDAVTCVAVSVTNKTQ-----VLSGSK 1439
            :|.|.:::.:.:...:.|      :||    |::|.||..||..:.....:.|:     .:|||.
Worm   451 SDGVIVMTYACETLARQWLRVPAERAT----SRILTGHDAAVRSMFYPFEHDTRYDPQYFVSGSD 511

  Fly  1440 DMNLILWDLLTGEEVHTLAGHLGPVIG----------------VKVSADGSTAVSGSDDKTLIVW 1488
            |.::|:|::.:|..:|....|.|||..                ..::||.:.|:....|...::.
Worm   512 DFSVIVWNINSGTRIHRFTVHGGPVKSFMLPPSNCSKQVTKCIASLAADNTIALLNIRDSKCMLL 576

  Fly  1489 ETKRGLALTSLQMHVPFTHFD-ISLEVSRVLVQLVDSYNLPVI---------------------- 1530
            .::....:..::.. |...|. :.|....|.|..:::.||..|
Worm   577 ASRHPFPIIQVKWR-PLDDFMLVKLADGSVYVWQMETANLDRIATGLLAEDIMTACDEQIGVEEG 640

  Fly  1531 --------------CLHN-------------------TPAQYVKLPTYSGPSKDV---EDLRPQG 1559
                          .|.|                   ||:.:.:|||..|.:..:   ..:.|..
Worm   641 TDETSAHHAVQLIRALKNKNMEAVKQKVVGGSVSGAATPSSHHELPTNCGTAVQLGSPMSILPLP 705

  Fly  1560 PKRQMKRLLKKEVS------LDTYTWQKKYGHLTSSVMMAQ---VDERLKRRFSVSASMEEISKI 1615
            ...|...|::.|:|      |          ||.||....:   ..::|....:..|| :..:.:
Worm   706 GCAQGAHLVQFEISALIAGIL----------HLDSSAEAPEGKTTAQKLDAAAAAGAS-DSATGL 759

  Fly  1616 AETKTGASQANLGPEQAALAQSQ-HF----DQLEALWNKR-SPPRRRHN---AGLSRQTSL---V 1668
            :...|...:|||..:.|.|..|. |.    :.::.:.:|| |..|.||.   ..:|||..|   :
Worm   760 SRKLTWQFEANLYLDVARLMLSMLHAWCLDEDMDEVCDKRLSLHRPRHQVYFGNVSRQGELSVSL 824

  Fly  1669 EDRLESSDDDEYQDERAGMLSASYDNIHHLARLPGLRSLHDAWKTNSLRVPSRSARTKFYVSTPP 1733
            ..|. ::|.:.:..:.....|.|.:..|.||.:....:|. |.|.::|::    |:.:..|.
Worm   825 PTRF-AADFESFCKKSRWQASHSLNTSHLLAVIATSNTLM-AMKNSALQL----AKIRKSVV--- 880

  Fly  1734 PQNSQNSSSLRLDSHVPG--QFTDG---------VVAPDLVRDLLS-VPPTV------------- 1773
               .||.|::    |.|.  |...|         |:.||.||...| .||::
Worm   881 ---EQNQSTI----HQPDRQQIKQGWSLVAALHCVLLPDHVRPRSSYAPPSIEMLVRRWQDSCLE 938

  Fly  1774 --ESPQRISLRQLLH------------W-----PSLKSRI----WRRQRNCQSLQPNIRLNP-PE 1814
              |:.|.:.:|:|..            |     |.|...:    .:.|.:..::||:....| |.
Worm   939 IREAAQALLIRELTRLGAEGRRRLIESWTPFLPPLLDDSLSIFGSKLQSSVPTVQPSAPAPPIPP 1003

  Fly  1815 RLRPTP 1820
            |.:..|
Worm  1004 RTKNAP 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934
		WD40 repeat	901..937	CDD:293791
		WD40	933..1282	CDD:238121	77/402 (19%)
		WD40 repeat	942..982	CDD:293791	10/41 (24%)
		WD40 repeat	988..1024	CDD:293791	10/55 (18%)
		WD40	1022..1484	CDD:225201	107/551 (19%)
		WD40 repeat	1029..1064	CDD:293791	3/34 (9%)
		WD40 repeat	1071..1106	CDD:293791	10/51 (20%)
		WD40 repeat	1112..1147	CDD:293791	10/42 (24%)
		WD40 repeat	1216..1252	CDD:293791	4/36 (11%)
		WD40	1248..1502	CDD:238121	63/299 (21%)
		WD40 repeat	1258..1294	CDD:293791	10/38 (26%)
		WD40 repeat	1299..1335	CDD:293791	9/35 (26%)
		WD40 repeat	1340..1374	CDD:293791	7/36 (19%)
		WD40 repeat	1379..1415	CDD:293791	8/51 (16%)
		WD40 repeat	1421..1458	CDD:293791	10/41 (24%)
		WD40 repeat	1464..1488	CDD:293791	5/39 (13%)
rbc-2	NP_001368042.1	WD40	27..>118	CDD:421866	20/91 (22%)
		WD40 repeat	33..68	CDD:293791	10/38 (26%)
		WD40 repeat	73..108	CDD:293791	9/34 (26%)
		WD40 repeat	112..160	CDD:293791	9/66 (14%)
		WD40 repeat	168..211	CDD:293791	9/45 (20%)
		WD40 repeat	264..291	CDD:293791	8/42 (19%)
		WD40	373..621	CDD:421866	55/257 (21%)
		WD40 repeat	488..530	CDD:293791	10/41 (24%)
		WD40 repeat	584..610	CDD:293791	5/26 (19%)
		WD40	<1246..1313	CDD:421866
		WD40 repeat	1286..1337	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900