DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30116 and qui-1

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_502613.2	Gene:	qui-1 / 178326	WormBaseID:	WBGene00004265	Length:	1592	Species:	Caenorhabditis elegans

Alignment Length:	1779	Identity:	421/1779 - (23%)
Similarity:	735/1779 - (41%)	Gaps:	373/1779 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PLLIKIY-VASLKQEFNQERRMLLELVGPELQSLYDDRQIELEFVDMHFGTGDLEVHQLERDPYL 89
            ||:..|: |.:.::|||.|||.|.:.|.|:||:|......:|||.|:....|:|.....|
Worm    33 PLVSTIFVVGNDEEEFNIERRTLWQDVLPDLQNLAFQSNFDLEFCDVPLENGELTNSVAE----- 92

  Fly    90 IHDYLHEIDTCHAHTKSVFFMVLVGDGIGRQLLPTKIDEDIFSAVLADQQTSADHEAMLVKWYER 154
                 |.:.....:.:| :.::|:|:..|...:||.:.::.:.::    ::|...|...|:.:|:
Worm    93 -----HVLQMWKDNPRS-WIVLLLGNRYGNVSVPTSLRKEEYESI----RSSIFEENGNVRVFEK 147

  Fly   155 DASQTQRQLKQDYRLMNVDAWLAESQRMQSFLEQAFQSLLQGSGASGRSPDFMERVQLLRRTQIE 219
            ..:..:....::|||  |.:.:.:.:::...::     .||....:......:.:|...|:   .
Worm   148 AYTINRNGAVEEYRL--VPSAIKDKKQLAEIIK-----ALQAGAKAAHEEGSINQVHEQRQ---N 202

  Fly   220 REVSQAMALTSEKILAVFRERAAQCSKGDVEAAERLRKIKDELTMNLSTDNHTTLVVPGSAASEA 284
            |..|..:......||.|     :.|     .....|||. |:|..:.::.|             |
Worm   203 RFFSSPLETFVRSILQV-----SPC-----RCLFLLRKF-DQLVADPNSPN-------------A 243

  Fly   285 IDPDNEDHESYLSKFKNKVTDKLRLLIEAHIT-----------NDPDVIKGRKKTVQEIFHEHAT 338
            ....|:.:...:...||::|.|:...:..|:.           |..|..|.|:|..::...:...
Worm   244 FLETNDQNSRKIEDLKNEITLKMNDRVMTHVLRPESTDINYFFNSRDGDKYREKIARQFNEKLKN 308

  Fly   339 HLRIL----REHTDSDALV----ESRVPQQLRQNLMA--NFRNG------------SRHAPYFLC 381
            ||..:    |.......:|    |:|..|:..:|.:|  |.:..            .....:.:.
Worm   309 HLADINPPVRPEPPKSPMVLAANEARTHQEFLENQLALGNLKRDYDKRLDELASVKVNRGVFLIQ 373

  Fly   382 GADGSGKSAILCHLYGQVGSWFGSTRVHRVIRFAKATPRSAYNLELLRVICQQISIIFNIPEGYL 446
            |.|..||:..||.||.::    .....::||.|...|..|.:..|..|.||..|..|.||
Worm   374 GTDLCGKTQALCRLYHKI----SDKDAYKVIFFTNLTYSSNFAHEAWRTICLNICSISNI----- 429

  Fly   447 PKDASFDPLYINTWFQ--NLLRRVEDM---GNDVLFLFIDDL------HLLNPLDCDIVTA---L 497
                  ||..:...|:  .:|:.:|::   .:..:.:||||:      |||:.:.....||   |
Worm   430 ------DPKEVLEHFKLGGILKSLEELVQKADKPVCIFIDDVHLLKFGHLLSQIGRRTETAPDNL 488

  Fly   498 SWLPTS---LPWNVQIICSSTTPVEQL------------------KFTPMQRDRFKSIEYQFDLN 541
            |...||   .|.|.....:.|..|:.:                  |.|..|....:.:....|
Worm   489 SLFMTSSNVAPVNAVFAVTQTVNVDVISENEVVGMVQKMAEKVDKKLTNEQISAIRPLMAAKD-- 551

  Fly   542 MGDYATKLKIPPQCIPGDVSFALYVEQQFDQLERHYGRQAVGDLASYITCSEYGLSETELLELLM 606
             |....|.........|:.|....::.:..::|:.:|:.|||:...:|..|.:||:..|:
Worm   552 -GILIAKSFTHEILFNGNSSMKGGMDGRMTRIEKEFGKLAVGNAVKFIAASSHGLTRLEI----- 610

  Fly   607 PTDDPESLIETKNGHFSFATFKKIHREMDL----LLLLHDKIMSG------KVLIQWR------H 655
                          |.:.:..:::..||::    .||..|.|:..      ||:|..|      |
Worm   611 --------------HDAISADREVLEEMNMSIVYSLLTLDGIIEALGPILRKVIIDDRQIIGIAH 661

  Fly   656 NYCASVAKRRYM-DVQRTRSLHCELANLFFPQDEDESTLENE-SNRSESKSVISLKDRDREKDSL 718
            :...|..:.||: ..|..||.|.:|::||     .:..::|| |.|.|
Worm   662 SGLISWLRNRYLTSSQDIRSAHLQLSDLF-----ADLLIDNEQSPRHE----------------- 704

  Fly   719 SAVSAVSAGRKSSSTHHNDDTSTFYNPIAADVSYSMRHVEESWHHLMRSDDTTRFKQIAVCNFDF 783
            .|..:.|.|.|..:...|                 .|.:...|:|.:.|.:..|.|::::|:|::
Worm   705 IAYQSFSQGIKRDNGSPN-----------------FRRLRLLWYHCLHSGNLDRLKELSLCHFEY 752

  Fly   784 LLAAVQTVSISYLRCLIEHVRCYILDRDIELIYYTIRKSSDVL-------TRDPMQLGSQLISWL 841
            :....:...||:|..|.|.....||..|:::|      |..||       .||..||.:::|..|
Worm   753 VDYVTRYFGISHLLSLYEECATQILHHDLQVI------SEQVLVPALVTMARDSEQLAAEVIGRL 811

  Fly   842 RPISEHDDDDNSLLSMTVRSATAWCDGY-AVPLLVPLTGWLPAPLPSQIRTMTVSGTGCIRAVW- 904
            | .:.|  :::..|:..|..|.:|.|.| ..|||||||.|:..|.....|:.|:..       |
Worm   812 R-FTRH--ENSHFLNSLVDQAMSWVDLYNRQPLLVPLTCWISPPATKVCRSFTLKD-------WK 866

  Fly   905 -------LAPSKQHLILATSSGD---VQQWHIMSNSLDHIFKGHTAAVTCLLVAPQSDSELLLTG 959
                   |:.:.|:::::.:..|   :..:||.|..|...|||||||||||  ...:||.|.::.
Worm   867 PGNTVLTLSANHQYILISGNQSDPGVIYAYHIASEQLIGTFKGHTAAVTCL--CSSNDSSLFVST 929

  Fly   960 SEDATVLVWHVGLRERRAHIKNAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITH 1024
            |.|.||.|| |..:.........|||.:|.....:::..:|::|.|:|..:..|.:|::......
Worm   930 SFDKTVNVW-VFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSAKMIKLETGEVMRSFND 993

  Fly  1025 HRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLLNTM-QMTSAVLRIDISWNSVFLLALCED 1088
            |.|.|..:.:......||:|..|..:.:||:.|...::.| .:.:.|..:.|:.|..|::..|||
Worm   994 HTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACED 1058

  Fly  1089 NALYVRTLATGKELHTLKGHKSKIRSISIGKDSQRC-VVGCDDTRALIYDMHAGKLVRSL-PPNP 1151
            ..|.|.:...|:|||.|.||:.|:.|:...:|.  | :.....::...||:|.|:::..| ...|
Worm  1059 ETLKVFSTVGGQELHELMGHEGKVNSLVCAQDD--CQLFAATKSKVFCYDIHNGQMIDVLDTAQP 1121

  Fly  1152 GPVTAVHAMDNDDFLVTVGGNKITFYSF--RNEELYVNPYSRHPRRKRSLKRHAQAQRSPSTTLP 1214
            .|:.::....::.||::..|.|:|.::.  ||.:.:              ..||..:..
Worm  1122 FPICSLKISSDNYFLISPCGPKVTIWNVTKRNHDAH--------------DVHADKEGF------ 1166

  Fly  1215 PITCFDLSRDSQQMAIASGRHVHLMRINTPEYQC---TLEGHTAGVSCLKFAPNGEFLATGSEDR 1276
             :|...||.|.:..|..:...: :...:....||   |::.....::|::::.:.::..:|::..
Worm  1167 -LTAVALSNDDKYAACGTNNGI-VALWDLEVCQCVFTTIQNKGDPITCIRYSVDSQYCISGNQAG 1229

  Fly  1277 LVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGN----LLQTIQGP 1337
            .:.|.:...|.:......|::.|:.::.|:.: ::||.|....:::|.....:    ::.|...|
Worm  1230 CILILDAQNGGVVRELFMHSSEVLSIMSLVHN-KMISCDIQGKMVIWELFGDDDTPEMVATGVKP 1293

  Fly  1338 YKSLSVTNNMRFAVSTNGDNTLKIWSLTQED---EKYSVSHSDEITCFEISADSVHII-SGSRDM 1398
            ...:..|..:.....:..:..:|||:..:|.   .:..:|||||||||..|....:.| :|||||
Worm  1294 PIFVPPTGRIMVGHCSLSNKEMKIWAFPEEGPPVTRAKLSHSDEITCFATSPKGGNFIATGSRDM 1358

  Fly  1399 SLKVWQATGGKLSQVLVGHSDAVTCVAVSVTNKTQVLSGSKDMNLILWDLLTGEEVHTLAGHLGP 1463
            |||:||...|.|:||||||.:.|||..:|...:. |:||::|..:|:|::.:|:.|.|: .....
Worm  1359 SLKIWQIDKGFLTQVLVGHENVVTCCCISFDERL-VVSGARDEKIIVWNVQSGDMVCTV-NTTAA 1421

  Fly  1464 VIGVKVSADGSTAVSGSDDKTLIVWETKRGLALTSLQMHVPFTHFDISLEVSRVLVQLVDSYNLP 1528
            :..:.::.|.:...|.::|..:..|.|.:|..|::...|.|......|.|..|:|:.|.:...||
Worm  1422 ITSLSMTGDSTVVFSTTEDGWVETWSTTKGRLLSTFNAHRPIKKLINSYESHRMLLLLENCAQLP 1486

  Fly  1529 VICLHNTPAQYVKLPTYSGPSKDVEDLRPQGPKRQMKRLLKKEVSLDTYTWQKKYGHLTSSVMMA 1593
            ::|||||||            ..||..|.:..:.|
Worm  1487 ILCLHNTPA------------VGVEATRRRSARAQ------------------------------ 1509

  Fly  1594 QVDERLKRRFSVSASMEEISKIAETKTG-------ASQANLGPEQA---ALAQSQHFDQLEALWN 1648
                      |||::..|  .:|.|..|       .|..|.|..|:   |.|....||.||
Worm  1510 ----------SVSSASNE--PVASTSAGEIKKDPILSSNNGGNAQSAPRATAPKPTFDMLE---- 1558

  Fly  1649 KRSPPRRRHNAGLSRQTSLVE-DR 1671
             ||..|          |||:| ||
Worm  1559 -RSKSR----------TSLIEKDR 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934	43/176 (24%)
		WD40 repeat	901..937	CDD:293791	9/46 (20%)
		WD40	933..1282	CDD:238121	89/356 (25%)
		WD40 repeat	942..982	CDD:293791	14/39 (36%)
		WD40 repeat	988..1024	CDD:293791	7/35 (20%)
		WD40	1022..1484	CDD:225201	118/477 (25%)
		WD40 repeat	1029..1064	CDD:293791	8/34 (24%)
		WD40 repeat	1071..1106	CDD:293791	12/34 (35%)
		WD40 repeat	1112..1147	CDD:293791	7/35 (20%)
		WD40 repeat	1216..1252	CDD:293791	8/38 (21%)
		WD40	1248..1502	CDD:238121	69/264 (26%)
		WD40 repeat	1258..1294	CDD:293791	4/35 (11%)
		WD40 repeat	1299..1335	CDD:293791	7/39 (18%)
		WD40 repeat	1340..1374	CDD:293791	5/36 (14%)
		WD40 repeat	1379..1415	CDD:293791	20/36 (56%)
		WD40 repeat	1421..1458	CDD:293791	13/36 (36%)
		WD40 repeat	1464..1488	CDD:293791	3/23 (13%)
qui-1	NP_502613.2	WD40 repeat	870..909	CDD:293791	8/38 (21%)
		WD40	903..1192	CDD:238121	84/315 (27%)
		WD40 repeat	914..950	CDD:293791	14/38 (37%)
		WD40 repeat	957..992	CDD:293791	7/34 (21%)
		WD40 repeat	998..1034	CDD:293791	8/35 (23%)
		WD40 repeat	1040..1077	CDD:293791	14/36 (39%)
		WD40 repeat	1082..1105	CDD:293791	3/24 (13%)
		WD40 repeat	1124..1158	CDD:293791	7/47 (15%)
		WD40	1157..1447	CDD:238121	73/314 (23%)
		WD40 repeat	1165..1191	CDD:293791	5/33 (15%)
		WD40 repeat	1211..1247	CDD:293791	4/35 (11%)
		WD40 repeat	1252..1291	CDD:293791	7/39 (18%)
		WD40 repeat	1296..1331	CDD:293791	5/34 (15%)
		WD40 repeat	1338..1375	CDD:293791	20/36 (56%)
		WD40 repeat	1381..1415	CDD:293791	12/34 (35%)
		WD40 repeat	1422..1446	CDD:293791	3/23 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I3359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14922
Inparanoid	1	1.050	361	1.000	Inparanoid score	I1280
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49333
OrthoDB	1	1.010	-	-		D102406at33208
OrthoFinder	1	1.000	-	-		FOG0016577
OrthoInspector	1	1.000	-	-		oto20444
orthoMCL	1	0.900	-	-		OOG6_114051
Panther	1	1.100	-	-	LDO	PTHR19871
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16923
SonicParanoid	1	1.000	-	-		X13471
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.970