DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prp19 and Prpf19

DIOPT Version :9

Sequence 1:NP_523783.1 Gene:Prp19 / 37123 FlyBaseID:FBgn0261119 Length:505 Species:Drosophila melanogaster
Sequence 2:NP_001240772.1 Gene:Prpf19 / 28000 MGIID:106247 Length:523 Species:Mus musculus


Alignment Length:529 Identity:336/529 - (63%)
Similarity:415/529 - (78%) Gaps:31/529 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MALVCALTNEVPETPVVSPHSGAVFEKRVIEKYLLENGCDPISGKELKPEELIEIKTPAVVKPKP 65
            |:|:|:::|||||.|.|||.|..|:|:|:||||:.|||.|||:.:.|..|:||:||....::|||
Mouse     1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKP 65

  Fly    66 PSATSIPATLKTMQDEW-------------------DALMIHSFTQRQQLQTTRQELSHALYQHD 111
            ||||||||.||.:||||                   ||:|:||||.|||||||||||||||||||
Mouse    66 PSATSIPAILKALQDEWGWPNSPALPQSSQWPTLSQDAVMLHSFTLRQQLQTTRQELSHALYQHD 130

  Fly   112 AACRVIARLNKEVAAAREALATLKPQAGIANAPTAIP--QPALASEAGGAAAHPM---EQAGMSA 171
            |||||||||.|||.||||||||||||||:. .|.|:|  ||::.     .|..||   |..||:.
Mouse   131 AACRVIARLTKEVTAAREALATLKPQAGLI-VPQAVPSSQPSVV-----GAGEPMDLGELVGMTP 189

  Fly   172 EVIQKLQDKATVLTQERKKRGRTVPEDLVTTDQVKNFLTVASHPGLHSASVPGILALDINSADHS 236
            |:||||||||||||.||||||:||||:||..:::..:..||||.||||||:|||||||:..:|.:
Mouse   190 EIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTN 254

  Fly   237 KILTGGNDKNATVFNKDTEQMVAILKGHTKKITKVIYHPNEDTVITGSPDMNIRIWHVPTSQTQL 301
            ||||||.|||..||:|.|||::|.|||||||:|.|::||:::.|.:.|||..||||.||.:....
Mouse   255 KILTGGADKNVVVFDKSTEQILATLKGHTKKVTSVVFHPSQELVFSASPDATIRIWSVPNTSCVQ 319

  Fly   302 LLRCHEGPVTGLSLHPTGDYLLSTSSDKHWAFSDIRTGRLLTKVID-TAEVGLTTAQFHPDGLIF 365
            ::|.||..|||||||.|||||||:|.|::||||||:|||:||||.| |:...||.||||||||||
Mouse   320 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIF 384

  Fly   366 GTGTVDSQVKIWDLKEQSNVANFPGHTGPISAISFSENGYYLATAADDACVKLWDLRKLKNFKTI 430
            ||||:|||:|||||||::||||||||:|||::|:||||||||||||||:.||||||||||||||:
Mouse   385 GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTL 449

  Fly   431 QLDDGYEVKDLCFDQSGTYLAIAGSDVRVYLCKQWQELKVFNDHTALATGVRFGKHAQYLASTSM 495
            |||:.:|||.|.|||||||||:.|:||::|:||||.|:..|.:|:.|.|||.||.||:::|||.|
Mouse   450 QLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGM 514

  Fly   496 DRTLKLYAI 504
            ||:||.|::
Mouse   515 DRSLKFYSL 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Prp19NP_523783.1 Ubox 2..68 CDD:128780 35/65 (54%)
Prp19 69..132 CDD:285771 54/81 (67%)
WD40 210..503 CDD:238121 198/293 (68%)
WD40 <225..505 CDD:225201 187/281 (67%)
WD40 repeat 269..305 CDD:293791 14/35 (40%)
WD40 repeat 310..345 CDD:293791 27/34 (79%)
WD40 repeat 354..389 CDD:293791 29/34 (85%)
WD40 repeat 395..431 CDD:293791 30/35 (86%)
WD40 repeat 438..484 CDD:293791 27/45 (60%)
Prpf19NP_001240772.1 RING-Ubox_PRP19 4..56 CDD:319570 28/51 (55%)
Prp19 69..152 CDD:400774 55/82 (67%)
WD40 242..522 CDD:238121 187/279 (67%)
WD40 repeat 243..281 CDD:293791 23/37 (62%)
WD40 repeat 287..323 CDD:293791 14/35 (40%)
WD40 repeat 328..363 CDD:293791 27/34 (79%)
WD40 repeat 373..408 CDD:293791 29/34 (85%)
WD40 repeat 414..450 CDD:293791 30/35 (86%)
WD40 repeat 457..483 CDD:293791 17/25 (68%)
WD40 repeat 495..521 CDD:293791 16/25 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850090
Domainoid 1 1.000 133 1.000 Domainoid score I5066
eggNOG 1 0.900 - - E1_KOG0289
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6421
Inparanoid 1 1.050 686 1.000 Inparanoid score I703
Isobase 1 0.950 - 0 Normalized mean entropy S1589
OMA 1 1.010 - - QHG54686
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003405
OrthoInspector 1 1.000 - - oto93663
orthoMCL 1 0.900 - - OOG6_102145
Panther 1 1.100 - - LDO PTHR43995
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R276
SonicParanoid 1 1.000 - - X2757
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.740

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