Protein Alignment Prp19 and PRPF19

DIOPT Version :10

• Sequence 1: NP_523783.1
• Gene: Prp19 / 37123
• FlyBaseID: FBgn0261119
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_055317.1
• Gene: PRPF19 / 27339
• HGNCID: 17896
• Length: 504
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 336/510 - (65%)
• Similarity: 415/510 - (81%)
• Gaps: 12/510 - (2%)

  Fly     1 MALVCALTNEVPETPVVSPHSGAVFEKRVIEKYLLENGCDPISGKELKPEELIEIKTPAVVKPKP 65
            |:|:|:::|||||.|.|||.|..|:|:|:||||:.|||.|||:.:.|..|:||:||....::|||
Human     1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKP 65

  Fly    66 PSATSIPATLKTMQDEWDALMIHSFTQRQQLQTTRQELSHALYQHDAACRVIARLNKEVAAAREA 130
            ||||||||.||.:||||||:|:||||.||||||||||||||||||||||||||||.|||.|||||
Human    66 PSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREA 130

  Fly   131 LATLKPQAGIANAPTAIP--QPALASEAGGAAAHPM---EQAGMSAEVIQKLQDKATVLTQERKK 190
            |||||||||:. .|.|:|  ||::.     .|..||   |..||:.|:||||||||||||.||||
Human   131 LATLKPQAGLI-VPQAVPSSQPSVV-----GAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKK 189

  Fly   191 RGRTVPEDLVTTDQVKNFLTVASHPGLHSASVPGILALDINSADHSKILTGGNDKNATVFNKDTE 255
            ||:||||:||..:::..:..||||.||||||:|||||||:..:|.:||||||.|||..||:|.:|
Human   190 RGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE 254

  Fly   256 QMVAILKGHTKKITKVIYHPNEDTVITGSPDMNIRIWHVPTSQTQLLLRCHEGPVTGLSLHPTGD 320
            |::|.|||||||:|.|::||::|.|.:.|||..||||.||.:....::|.||..|||||||.|||
Human   255 QILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 319

  Fly   321 YLLSTSSDKHWAFSDIRTGRLLTKVID-TAEVGLTTAQFHPDGLIFGTGTVDSQVKIWDLKEQSN 384
            ||||:|.|::||||||:|||:||||.| |:...||.||||||||||||||:|||:|||||||::|
Human   320 YLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN 384

  Fly   385 VANFPGHTGPISAISFSENGYYLATAADDACVKLWDLRKLKNFKTIQLDDGYEVKDLCFDQSGTY 449
            |||||||:|||::|:||||||||||||||:.||||||||||||||:|||:.:|||.|.|||||||
Human   385 VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTY 449

  Fly   450 LAIAGSDVRVYLCKQWQELKVFNDHTALATGVRFGKHAQYLASTSMDRTLKLYAI 504
            ||:.|:||::|:||||.|:..|.:|:.|.|||.||.||:::|||.|||:||.|::
Human   450 LALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp19	NP_523783.1	RING-Ubox_PRP19	3..56	CDD:438318	29/52 (56%)
		Prp19	69..133	CDD:400774	55/63 (87%)
		WD40	210..503	CDD:238121	198/293 (68%)
		WD40 repeat	269..305	CDD:293791	15/35 (43%)
		WD40 repeat	310..345	CDD:293791	27/34 (79%)
		WD40 repeat	354..389	CDD:293791	29/34 (85%)
		WD40 repeat	395..431	CDD:293791	30/35 (86%)
		WD40 repeat	438..484	CDD:293791	27/45 (60%)
PRPF19	NP_055317.1	RING-Ubox_PRP19	3..56	CDD:438318	29/52 (56%)
		May mediate interaction with PSMC5. /evidence=ECO:0000250|UniProtKB:Q99KP6	68..223		110/160 (69%)
		Prp19	69..133	CDD:400774	55/63 (87%)
		WD 1	219..259		24/39 (62%)
		WD40 repeat	224..262	CDD:293791	22/37 (59%)
		WD40	<233..504	CDD:441893	182/270 (67%)
		WD 2	262..301		20/38 (53%)
		WD40 repeat	268..304	CDD:293791	15/35 (43%)
		WD 3	304..345		30/40 (75%)
		WD40 repeat	309..344	CDD:293791	27/34 (79%)
		WD 4	348..387		29/38 (76%)
		WD40 repeat	354..389	CDD:293791	29/34 (85%)
		WD 5	390..429		32/38 (84%)
		WD40 repeat	395..431	CDD:293791	30/35 (86%)
		WD 6	433..472		23/38 (61%)
		WD40 repeat	438..464	CDD:293791	17/25 (68%)
		WD 7	473..503		17/29 (59%)
		WD40 repeat	476..502	CDD:293791	16/25 (64%)