DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slim and KEL1

DIOPT Version :9

Sequence 1:	NP_523782.1	Gene:	slim / 37121	FlyBaseID:	FBgn0261477	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_012028.1	Gene:	KEL1 / 856563	SGDID:	S000001201	Length:	1164	Species:	Saccharomyces cerevisiae

Alignment Length:	477	Identity:	94/477 - (19%)
Similarity:	176/477 - (36%)	Gaps:	104/477 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 EFEEMY-SDEWTSSSDELDEGTELSKSVL----------NVFLSSDKQQSQMAGQIPMYAFQPLR 184
            :|.:.| |:...:||..:....::|:|.:          ||...|.....|::.|.....:..::
Yeast    53 QFSQGYHSNVNKTSSPPMFARKQVSESRIQPSAVPPQQRNVSGPSTTLHKQLSKQREYTVWNRIK 117

  Fly   185 LVKCQY-RDKHIPGGFPLARSGHRIIASNSHLYSLGGYNPRSAMSASRHGRCLLFQELW---SYN 245
            |....: |.:|:...:         :...:.:|.:||.:.:|           ::.:.|   :::
Yeast   118 LQNSPFPRYRHVASAY---------VTDKNQIYVIGGLHDQS-----------VYGDTWILTAFD 162

  Fly   246 FATRTWRLELNAGNAANMPVELASNALTIHNNVLISHGGTGYPFGVS--CSNDCYVYRTASAGAT 308
            .|||.....::...|.  |.....:|..:..|..:..||..:.....  ..:|.|:....|...|
Yeast   163 NATRFSTTTIDISEAT--PPPRVGHAAVLCGNAFVVFGGDTHKVNKEGLMDDDIYLLNINSYKWT 225

  Fly   309 PGVDRLQVKGDLPTAQYGPGIVI-----HKHFLYTIGGTTGFDYTCDVYRLDLRT-----GIWEN 363
            ....    .|..|..:||..|.|     .|..||..||.....|..|:...||.:     ..||
Yeast   226 VPAP----VGPRPLGRYGHKISIIATTQMKTKLYVFGGQFDDTYFNDLAVYDLSSFRRPDSHWE- 285

  Fly   364 VYISRPEMRDDPEGRYRHEVVYDGKHIFVLGGGTSHSVYDLQRIPAYNLEANCWDYFETYPDQRA 428
              ..:|.....|.......:.||.| ::|.||.|...:  :..:..|:...|.|...:|..::
Yeast   286 --FLKPRTFTPPPITNFTMISYDSK-LWVFGGDTLQGL--VNDVFMYDPAINDWFIIDTTGEK-- 343

  Fly   429 ADADDGNRGYPKPRKCFSCVQHQSST--GDIEAFITGGLQGDFSTYFSDIWKLNLRTKHWYRIE- 490
                      |.|      ||..::.  .|:...:.|  :.:...|.:.::.|||:::.|:::.
Yeast   344 ----------PPP------VQEHATVVYNDLMCVVGG--KDEHDAYLNSVYFLNLKSRKWFKLPV 390

  Fly   491 -TAILPRPLYFHSAAHSDNGCMYVFGGIEY------------IDKEMRRRNDLYKMWMTVPKLSE 542
             ||.:|:....||.....|..:.:.||.::            .|.:|:|...:|.  :.:.::.:
Yeast   391 FTAGIPQGRSGHSLTLLKNDKILIMGGDKFDYARVEEYDLHTSDIDMQRGTIVYT--LDLARIKD 453

  Fly   543 MC-------WDAITYYNDNLDL 557
            :|       .|..|..|.||||
Yeast   454 LCPGVMDVPTDTPTPRNGNLDL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slim	NP_523782.1	KELCH repeat	203..263	CDD:276965	9/62 (15%)
		KELCH repeat	267..321	CDD:276965	9/55 (16%)
		KELCH repeat	324..364	CDD:276965	15/49 (31%)
		Kelch_1	325..372	CDD:279660	16/56 (29%)
		Kelch_4	441..492	CDD:290154	10/54 (19%)
		KELCH repeat	442..495	CDD:276965	11/56 (20%)
KEL1	NP_012028.1	Kelch_5	122..163	CDD:404696	7/60 (12%)
		KELCH repeat	125..179	CDD:276965	11/75 (15%)
		PLN02153	179..420	CDD:177814	58/270 (21%)
		KELCH repeat	182..233	CDD:276965	9/54 (17%)
		KELCH repeat	237..293	CDD:276965	16/58 (28%)
		KELCH repeat	299..345	CDD:276965	11/60 (18%)
		KELCH repeat	347..396	CDD:276965	11/50 (22%)
		Smc	<767..1078	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0379
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900