Protein Alignment slim and KEL2

DIOPT Version :9

• Sequence 1: NP_523782.1
• Gene: slim / 37121
• FlyBaseID: FBgn0261477
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_011754.3
• Gene: KEL2 / 853153
• SGDID: S000003470
• Length: 882
• Species: Saccharomyces cerevisiae
• Alignment Length: 729
• Identity: 143/729 - (19%)
• Similarity: 242/729 - (33%)
• Gaps: 220/729 - (30%)

  Fly    54 NNNNNDLIMEQDMPEEE---VGQPEEALPQQDNGEVVDRFNAIQAAVELMDAASDLDEEEEE--E 113
            :|.||..|:...:|..:   :.....|||.....:...::  |...|:|.::..........  .
Yeast    32 DNRNNTRIVTPTLPPNQHRGISGASTALPWSPESKNTGKY--IWNRVKLKNSPFPRYRHSSSFIV 94

  Fly   114 DDDVDVDVDYGDTDSESEFEEMYSDEW-----------TSSSDELDEGT------ELSKSVLNVF 161
            .:|..:.|..|..|     :.:|.|.|           ||...::|:.|      ..|....|.:
Yeast    95 TNDNRIFVTGGLHD-----QSVYGDVWQIAANADGTSFTSKRIDIDQNTPPPRVGHASTICGNAY 154

  Fly   162 L--SSDKQQSQMAGQI--PMYAF----------QPLRLVKCQYRDKHIPGGFPLARSGHR--IIA 210
            :  ..|..:....|.:  .:|.|          ||:             |..||.|.||:  |||
Yeast   155 VVFGGDTHKLNKNGLLDDDLYLFNINSYKWTIPQPI-------------GRRPLGRYGHKISIIA 206

  Fly   211 SN---SHLYSLGGYNPRSAMSASRHGRCLLFQELWSYNFATRTWRLELNAGNAANMPVELASNAL 272
            ||   :.||..||....:..:.      |:..:|.|:......|......|   ::|..|.::.:
Yeast   207 SNPMQTKLYLFGGQVDETYFND------LVVFDLSSFRRPNSHWEFLEPVG---DLPPPLTNHTM 262

  Fly   273 TIHNNVLISHGGTGYPFGVSCSNDCYVYRTASAGATPGVDRLQVKGDLPTAQYGPGIVIHKHFLY 337
            ..::|.|...||   ....:.|||.|.|..|.:..:    :::..|:.|........|::||.:.
Yeast   263 VAYDNKLWVFGG---ETPKTISNDTYRYDPAQSEWS----KVKTTGEKPPPIQEHASVVYKHLMC 320

  Fly   338 TIGG-TTGFDYTCDVYRLDLRTGIWENVYISRPEMRDD-PEGRYRHEV-VYDGKHIFVLGGG--- 396
            .:|| .|...|:.|||.|:|.:..|..:    |.|::. |:.|..|.: :...:.:.::||.
Yeast   321 VLGGKDTHNAYSNDVYFLNLLSLKWYKL----PRMKEGIPQERSGHSLTLMKNEKLLIMGGDKTD 381

  Fly   397 -TSHSVYDLQ------------------------------------------------------- 405
             .|.:::|||
Yeast   382 YASPNIHDLQTSETDQGEGTLLYTLDLSSLNELCPGIMCESLHAGESFSNSLSGGFTPSKSTESE 446

  Fly   406 ----------RIP-----AYN-LEANCWDYFETYPDQRAADADDGNRGYPKPRKCFSCVQHQSST 454
                      |:|     :|| ::.....|.....|:......|.....|:..|..|.:..:|..
Yeast   447 NQEIINILTPRLPDSKVLSYNDIDEGAGSYSSALDDKAFERKSDREEKKPQSSKVDSSINKESPG 511

  Fly   455 GDIEAF-----ITGGLQGDFSTYFSDIWK-----------------LNLRT-------------K 484
            ..|:..     :..||..|...|.|..:|                 |||:|             :
Yeast   512 TGIKVSKKNFPVLRGLTVDSEEYGSSSYKDTSCQKGIPKNLFDDLNLNLQTLRLEAQQKELETAR 576

  Fly   485 HWYRIETAILPRPLYFHSAAHSDNGCMYVFGGIEYIDKEM--RRRNDLYKMWMT-VPKLSEMCWD 546
            |..::|..: .|.:....|:...|........:| |.|..  .|.|||..:.|. :.:.|::| |
Yeast   577 HISQLEKEV-QRLMVIKEASKDSNFQTARLKNLE-IQKTFLESRINDLKNLLMVKLSQASKLC-D 638

  Fly   547 AITYYNDNL-----------DLYDRKTLLEAGIPKRFTE-------RLPPQRRRRLDTSQPDPSM 593
            .||..|:.|           |:.|.:.  :..:.||..|       ::.|:....|:.|......
Yeast   639 QITIQNNGLKTCSEHVTIKRDIIDLEN--KCDVLKRQNEILVNNMQKITPELHTYLNESSCYLGK 701

  Fly   594 LISLYSNPKRARSS 607
            |:..|....|..||
Yeast   702 LLKSYPTSARPPSS 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slim	NP_523782.1	KELCH repeat	203..263	CDD:276965	17/64 (27%)
		KELCH repeat	267..321	CDD:276965	12/53 (23%)
		KELCH repeat	324..364	CDD:276965	13/40 (33%)
		Kelch_1	325..372	CDD:279660	14/47 (30%)
		Kelch_4	441..492	CDD:290154	16/85 (19%)
		KELCH repeat	442..495	CDD:276965	16/87 (18%)
KEL2	NP_011754.3	Kelch_5	82..116	CDD:404696	6/38 (16%)
		PLN02153	139..379	CDD:177814	62/272 (23%)
		KELCH repeat	142..190	CDD:276965	7/47 (15%)
		KELCH repeat	257..308	CDD:276965	13/57 (23%)
		KELCH repeat	310..353	CDD:276965	15/46 (33%)
		Smc	<603..>882	CDD:224117	28/117 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0379
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900