DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slim and FBXO42

DIOPT Version :9

Sequence 1:	NP_523782.1	Gene:	slim / 37121	FlyBaseID:	FBgn0261477	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_061867.1	Gene:	FBXO42 / 54455	HGNCID:	29249	Length:	717	Species:	Homo sapiens

Alignment Length:	341	Identity:	80/341 - (23%)
Similarity:	129/341 - (37%)	Gaps:	85/341 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 MDAASDLDEEEEEEDD-----DVDVDVDYGDTDSESEFEEMYSDEWTSSSDELDEGTELSKSVLN 159
            |.::||      .|||     |.:..|..|..|.:.|...:...|.|..:..:   :||.:.||.
Human     1 MASSSD------SEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSM---SELPEEVLE 56

  Fly   160 VFLS--SDKQQSQMAGQIPMYAFQPLRLVK-----C-------------QYRDKHIP-GGFPLA- 202
            ..||  |..|:.:.|.   :...|..||:|     |             |:..:..| .|.|:.
Human    57 YILSFLSPYQEHKTAA---LVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQ 118

  Fly   203 RSGHR--IIASNSHLYSLGGYNPRSAMSASRHGRCLLFQELWSYNFATRTWRLELNAGNAANMPV 265
            |..|.  ...:|..:|..||....|..:|        |.:||..:..::.|...|.:|   :.|.
Human   119 RFSHSACYYDANQSMYVFGGCTQSSCNAA--------FNDLWRLDLNSKEWIRPLASG---SYPS 172

  Fly   266 ELASNALTIHNNVLISHGG----TGYP-------FGVSCSNDCYVYRTASAGATPGVD----RLQ 315
            ..|...|.::.::|:..||    :.||       |     ::.:.|       :|..:    .:.
Human   173 PKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFF-----DEIHTY-------SPSKNWWNCIVT 225

  Fly   316 VKGDLPTAQYGPGIVIHKHFLYTIGGTTGF-DYTCDVYRLDLRTGIWENVYISRPEMRDDPEGRY 379
            ..|..|.|.:...::..|..::  ||:.|. ..:.||:.|||....|....||.|.  ..|.|.
Human   226 THGPPPMAGHSSCVIDDKMIVF--GGSLGSRQMSNDVWVLDLEQWAWSKPNISGPS--PHPRGG- 285

  Fly   380 RHEVVYDGKHIFVLGG 395
            :.::|.|...|.:|||
Human   286 QSQIVIDDATILILGG 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slim	NP_523782.1	KELCH repeat	203..263	CDD:276965	14/61 (23%)
		KELCH repeat	267..321	CDD:276965	11/68 (16%)
		KELCH repeat	324..364	CDD:276965	10/40 (25%)
		Kelch_1	325..372	CDD:279660	13/47 (28%)
		Kelch_4	441..492	CDD:290154
		KELCH repeat	442..495	CDD:276965
FBXO42	NP_061867.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		11/38 (29%)
		F-box-like	47..>82	CDD:315592	11/40 (28%)
		KELCH repeat	119..168	CDD:276965	13/56 (23%)
		Kelch_3	130..182	CDD:315978	15/62 (24%)
		Kelch 1	132..184		14/62 (23%)
		KELCH repeat	174..229	CDD:276965	10/66 (15%)
		Kelch_3	183..240	CDD:315978	11/68 (16%)
		Kelch 2	186..242		11/67 (16%)
		Guanylate_kin	228..>360	CDD:331880	24/79 (30%)
		Kelch_5	229..268	CDD:316377	11/40 (28%)
		KELCH repeat	232..271	CDD:276965	10/40 (25%)
		Kelch 3	244..293		15/53 (28%)
		Kelch 4	295..342		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..474
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0379
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810