DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slim and klhdc10

DIOPT Version :9

Sequence 1:	NP_523782.1	Gene:	slim / 37121	FlyBaseID:	FBgn0261477	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	XP_005164752.1	Gene:	klhdc10 / 393231	ZFINID:	ZDB-GENE-040426-776	Length:	424	Species:	Danio rerio

Alignment Length:	449	Identity:	173/449 - (38%)
Similarity:	240/449 - (53%)	Gaps:	40/449 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 MYSDEWTSSSDELDEGTELS-KSVLNVFLSSDKQQSQMAGQIPMYAFQPLRLVKCQYRDKHIPGG 198
            |:..|...|.|.|::...|| :..|....|..:.....|.:|..:....||:.....|:.|   .
Zfish     8 MFGAEGAHSPDRLNQFERLSGRPPLRAAGSKKRVSWLQARRIFGHPSPSLRIPNRFLREGH---R 69

  Fly   199 FPLARSGHRIIASNSHLYSLGGYNP-RSAMSASRHGRCLLFQELWSYNFATRTWRLELNAGNAAN 262
            .|.||||||.:|.|::||..||||| ......|.:....||:|||.::|||.||:.....|   .
Zfish    70 APPARSGHRCVADNTNLYVFGGYNPDYDESGGSENEDYPLFRELWRFHFATGTWQQIRTEG---F 131

  Fly   263 MPVELASNALTIHNNVLISHGGTGYPFGVSCSNDCYV----YRTASAGATPGVDRLQVKGDLPTA 323
            ||.||||.:..:|.|.|:..||||.|||.:..||.:|    |:..|.        |..:|..|..
Zfish   132 MPTELASMSAVLHGNNLLVFGGTGIPFGENNGNDVHVCNVKYKRWSL--------LNCRGKKPNR 188

  Fly   324 QYGPGIVIHKHFLYTIGGTTGFDYTCDVYRLDLRTGIWENVYISRPEMRDD-PEGRYRHEVVYDG 387
            .||..:.|...|||..|||||:.|:.|::||||.|..|.::..:.|.  || ||.|||||:.:||
Zfish   189 IYGQAMAIISGFLYVFGGTTGYIYSTDLHRLDLTTREWIHLKPNNPP--DDLPEERYRHEIAHDG 251

  Fly   388 KHIFVLGGGTSHSVYDLQRIPAYNLEANCWDYFETYPDQRAADADDGNRGYPKPRKCFSCVQHQS 452
            :.|::||||||.:.|.|.:|.|||||.|.|:...|.|.:|.        |||.||:|.||||.::
Zfish   252 QRIYILGGGTSWTSYPLDKIHAYNLETNSWEEITTKPHERI--------GYPAPRRCHSCVQIKN 308

  Fly   453 STGDIEAFITGGLQGDFSTYFSDIWKLNLRTKHWYRIETAILPRPLYFHSAAHSDNGCMYVFGGI 517
                 :.||.||..|:  ....|:||:||:|..|::: .|::|.|.|||.||.:..||||:.||:
Zfish   309 -----DVFICGGYNGE--VILDDLWKVNLQTFQWHKL-PAVMPEPAYFHCAAVTPAGCMYIHGGV 365

  Fly   518 EYIDKEMRRRNDLYKMWMTVPKLSEMCWDAITYYNDNLDLYDRKTLLEAGIPKRFTERL 576
            ..| .|.:|...|:|:|:.||.|.|:||:.:.....:|.......||..|:.:...|||
Zfish   366 VNI-HENKRTGSLFKIWLVVPSLLELCWERLLKAFPHLAQLTPIQLLNLGLTQELIERL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slim	NP_523782.1	KELCH repeat	203..263	CDD:276965	26/60 (43%)
		KELCH repeat	267..321	CDD:276965	20/57 (35%)
		KELCH repeat	324..364	CDD:276965	19/39 (49%)
		Kelch_1	325..372	CDD:279660	20/46 (43%)
		Kelch_4	441..492	CDD:290154	19/50 (38%)
		KELCH repeat	442..495	CDD:276965	19/52 (37%)
klhdc10	XP_005164752.1	PLN02153	65..378	CDD:177814	144/345 (42%)
		Kelch_4	73..126	CDD:290154	26/52 (50%)
		KELCH repeat	74..132	CDD:276965	26/60 (43%)
		KELCH repeat	136..186	CDD:276965	20/57 (35%)
		Kelch_4	188..226	CDD:290154	18/37 (49%)
		KELCH repeat	190..238	CDD:276965	21/49 (43%)
		KELCH repeat	242..295	CDD:276965	28/60 (47%)
		Kelch_1	242..288	CDD:279660	25/45 (56%)
		Kelch_1	297..339	CDD:279660	19/49 (39%)
		KELCH repeat	298..344	CDD:276965	19/53 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I10007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15267
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2917
OMA	1	1.010	-	-		QHG49432
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007461
OrthoInspector	1	1.000	-	-		oto41395
orthoMCL	1	0.900	-	-		OOG6_106219
Panther	1	1.100	-	-	LDO	PTHR46428
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4153
SonicParanoid	1	1.000	-	-		X5591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.960