DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slim and Klhdc2

DIOPT Version :9

Sequence 1:	NP_523782.1	Gene:	slim / 37121	FlyBaseID:	FBgn0261477	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001029305.1	Gene:	Klhdc2 / 299113	RGDID:	1306504	Length:	406	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	90/383 - (23%)
Similarity:	142/383 - (37%)	Gaps:	77/383 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 SDKQQSQMAGQIPMYAFQPLRLVK--CQYRDKHIPGGFPLARSGHRIIASNSHLYSLGGYNPRSA 226
            :|..:...|..:|..||:....::  |           |..||||..::...|::..|||  :|.
  Rat     2 ADGNEDARAEDMPGPAFEGYEAMELAC-----------PAERSGHVAVSDGRHMFVWGGY--KSN 53

  Fly   227 MSASRHGRCLLFQELWSYNFATRTWRLELNAGNAANMPVELASNALTIHNNVLISHGGTGYPFGV 291
            .....:...|..:|||.||..|..|: ::|  ...::|..::.:.....:.||...||   ....
  Rat    54 QVRGLYDFYLPREELWIYNMETGRWK-KIN--TEGDVPPSMSGSCAVCVDRVLYLFGG---HHSR 112

  Fly   292 SCSNDCYVYRTASAGATPGVDRLQVKGDLPTAQYGPGIVIHKHFLYTIG-----------GTTGF 345
            ..:|..|:..:.||......:|:..:|..|:::...|:.::|:.|...|           ||..|
  Rat   113 GNTNKFYMLDSRSADRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEF 177

  Fly   346 DYTC------------DVYRLDLRTGIWENVYISRP-EMRDDPEGRYRHEVVYDGKHIFVLGGGT 397
            |.|.            .|:.||..|..|     |:| .....|..|..|.....|...||.||
  Rat   178 DETSFWNSSHPRGWNDHVHILDTETFAW-----SQPITTGKAPSPRAAHACATVGNKGFVFGG-- 235

  Fly   398 SHSVYDLQRIPAYNLEANCWDYFETYPDQRAADADDGNRGY-PKPRKCFSCVQHQSSTGDIEAFI 461
              ...|.:....:.|..:.|::.|..|           :|. |..|...|.....|.    ..|:
  Rat   236 --RYRDARMNDLHYLNLDTWEWNELIP-----------QGICPVGRSWHSLTPVSSD----HLFL 283

  Fly   462 TGGLQGDFSTY---FSDIWKLNLRTKHWYRIETAILPRPLYFHSAAHSDNGCMYVFGG 516
            .||    |:|.   .||.|...:....|.:.....:.:|..:|:|..||.|.:.||||
  Rat   284 FGG----FTTEKQPLSDAWTYCISKNEWIQFNHPYVEKPRLWHTACASDEGEVIVFGG 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slim	NP_523782.1	KELCH repeat	203..263	CDD:276965	18/59 (31%)
		KELCH repeat	267..321	CDD:276965	10/53 (19%)
		KELCH repeat	324..364	CDD:276965	14/62 (23%)
		Kelch_1	325..372	CDD:279660	16/70 (23%)
		Kelch_4	441..492	CDD:290154	12/53 (23%)
		KELCH repeat	442..495	CDD:276965	12/55 (22%)
Klhdc2	NP_001029305.1	PLN02193	<29..296	CDD:177844	70/302 (23%)
		KELCH repeat	32..91	CDD:276965	19/63 (30%)
		Kelch 1	43..89		14/50 (28%)
		KELCH repeat	92..138	CDD:276965	9/48 (19%)
		Kelch 2	102..155		12/55 (22%)
		Kelch 3	157..202		10/44 (23%)
		KELCH repeat	218..265	CDD:276965	13/61 (21%)
		Kelch 4	229..278		13/63 (21%)
		Kelch_3	279..326	CDD:404319	12/54 (22%)
		Kelch 5	280..329		13/52 (25%)
		Kelch 6	331..377		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0379
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810