DRSC/TRiP Functional Genomics Resources

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Protein Alignment slim and Klhdc1

DIOPT Version :9

Sequence 1:NP_523782.1 Gene:slim / 37121 FlyBaseID:FBgn0261477 Length:609 Species:Drosophila melanogaster
Sequence 2:NP_839984.1 Gene:Klhdc1 / 271005 MGIID:2672853 Length:406 Species:Mus musculus


Alignment Length:444 Identity:104/444 - (23%)
Similarity:163/444 - (36%) Gaps:94/444 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   196 PGGFPLA--RSGHRIIASNSHLYSLGGYNPRSAMSASRHGRCLLFQELWSYNFATRTWRLELNAG 258
            |..|.:|  ||||..:.....||..|||     :|...:...|...|:|:|:..:..|::.|..|
Mouse     4 PQAFCVAEERSGHCAVVDGHFLYVWGGY-----VSIEDNEVYLPNDEMWTYDIDSGLWKMHLMEG 63

  Fly   259 NAANMPVELA-SNALTIHNNVLISHG--GTGYPFGVSCSNDCYVYRTASAGATPGVDRL-QVKGD 319
               .:|..:: |....||..:.:..|  ..||      ||..|.....:...|...::: :..|.
Mouse    64 ---ELPPSMSGSCGACIHGRLYVFGGYDDKGY------SNRLYFVNLRTRDGTYTWEKITKFDGQ 119

  Fly   320 LPTAQYGPGIVIHKHFLYTIGGTTGFDY-------TC------------------DVYRLDLRTG 359
            .||.:......::|..|...|   |:.|       .|                  ||:..|.:|.
Mouse   120 PPTPRDKLSCWVYKDRLIYFG---GYGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTR 181

  Fly   360 IWENVYISRPEMRD--DPEGRYRHEVVYDGKHIFVLGGGTSHS-VYDLQRIPAYNLEANCWDYFE 421
            .|     |:||::.  .|:.|..|.....|...:|.||....: :.||..:   ||:...|    
Mouse   182 TW-----SQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRVLQTRMNDLHYL---NLDTWVW---- 234

  Fly   422 TYPDQRAADADDGNRGYPKPRKCFSCVQHQSSTGDIEAFITGGLQGDFSTYFSDIWKLNLRTKHW 486
                   :.....|...||.|...:.    ::..|.:.|:.|||..| :...||.|..|:.|..|
Mouse   235 -------SGRISVNGESPKHRSWHTL----TAITDDKLFLFGGLNAD-NIPLSDGWIHNITTNCW 287

  Fly   487 YRIETAILPRPLYFHSAAHSDNGCMYVFGG----IEYIDKEMRRRNDLYKMWMTVP-KLSEMCWD 546
            .::......||..:|:|.......:.||||    :.::|  ....|||. ::.|.| .|...|.|
Mouse   288 KQLRHLPYTRPRLWHTACLGKENEIMVFGGSKDNLLFLD--TGHCNDLL-IFQTQPYSLLRSCLD 349

  Fly   547 AI----TYYNDNLDLYDRKTLLEAGIPKRFT-----ERLPPQRRRRLDTSQPDP 591
            .|    ......:.|...|.|.:  :.|:.|     .....||.|:.:|....|
Mouse   350 CIGKNAIILKSQISLLPPKLLQQ--VLKKITFWTAANYRKEQRIRKEETENNQP 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slimNP_523782.1 KELCH repeat 203..263 CDD:276965 17/59 (29%)
KELCH repeat 267..321 CDD:276965 11/57 (19%)
KELCH repeat 324..364 CDD:276965 11/64 (17%)
Kelch_1 325..372 CDD:279660 14/71 (20%)
Kelch_4 441..492 CDD:290154 13/50 (26%)
KELCH repeat 442..495 CDD:276965 13/52 (25%)
Klhdc1NP_839984.1 KELCH repeat 13..66 CDD:276965 17/60 (28%)
Kelch_5 13..54 CDD:290565 14/45 (31%)
Kelch 1 24..76 15/59 (25%)
KELCH repeat 70..120 CDD:276965 11/55 (20%)
Kelch_3 79..124 CDD:290151 10/50 (20%)
Kelch 2 80..134 10/59 (17%)
Kelch 3 135..181 8/48 (17%)
Kelch_3 <170..205 CDD:290151 11/39 (28%)
KELCH repeat 197..245 CDD:276965 12/61 (20%)
Kelch_3 206..256 CDD:290151 13/67 (19%)
Kelch 4 208..258 12/67 (18%)
Kelch_4 247..295 CDD:290154 13/52 (25%)
KELCH repeat 248..295 CDD:276965 13/51 (25%)
Kelch 5 260..307 15/47 (32%)
Kelch 6 311..361 14/52 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0379
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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