DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment slim and KLHDC2

DIOPT Version :9

Sequence 1:NP_523782.1 Gene:slim / 37121 FlyBaseID:FBgn0261477 Length:609 Species:Drosophila melanogaster
Sequence 2:NP_055130.1 Gene:KLHDC2 / 23588 HGNCID:20231 Length:406 Species:Homo sapiens


Alignment Length:378 Identity:88/378 - (23%)
Similarity:137/378 - (36%) Gaps:67/378 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 SDKQQSQMAGQIPMYAFQPLRLVKCQYRDKHIPGGFPLARSGHRIIASNSHLYSLGGYNPRSAMS 228
            :|..:...|..:|..||:       .|....:  ..|..||||..::...|::..|||  :|...
Human     2 ADGNEDLRADDLPGPAFE-------SYESMEL--ACPAERSGHVAVSDGRHMFVWGGY--KSNQV 55

  Fly   229 ASRHGRCLLFQELWSYNFATRTWRLELNAGNAANMPVELASNALTIHNNVLISHGGTGYPFGVSC 293
            ...:...|..:|||.||..|..|: ::|  ...::|..::.:.....:.||...||   ......
Human    56 RGLYDFYLPREELWIYNMETGRWK-KIN--TEGDVPPSMSGSCAVCVDRVLYLFGG---HHSRGN 114

  Fly   294 SNDCYVYRTASAGATPGVDRLQVKGDLPTAQYGPGIVIHKHFLYTIG-----------GTTGFDY 347
            :|..|:..:.|.......:|:..:|..|:::...|:.::|:.|...|           ||..||.
Human   115 TNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDE 179

  Fly   348 TC------------DVYRLDLRTGIWENVYISRP-EMRDDPEGRYRHEVVYDGKHIFVLGGGTSH 399
            |.            .|:.||..|..|     |:| .....|..|..|.....|...||.||    
Human   180 TSFWNSSHPRGWNDHVHILDTETFTW-----SQPITTGKAPSPRAAHACATVGNRGFVFGG---- 235

  Fly   400 SVYDLQRIPAYNLEANCWDYFETYPDQRAADADDGNRGY-PKPRKCFSCVQHQSSTGDIEAFITG 463
            ...|.:....:.|..:.|::.|..|           :|. |..|...|.....|.    ..|:.|
Human   236 RYRDARMNDLHYLNLDTWEWNELIP-----------QGICPVGRSWHSLTPVSSD----HLFLFG 285

  Fly   464 GLQGDFSTYFSDIWKLNLRTKHWYRIETAILPRPLYFHSAAHSDNGCMYVFGG 516
            |...| ....||.|...:....|.:.......:|..:|:|..||.|.:.||||
Human   286 GFTTD-KQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGG 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slimNP_523782.1 KELCH repeat 203..263 CDD:276965 18/59 (31%)
KELCH repeat 267..321 CDD:276965 9/53 (17%)
KELCH repeat 324..364 CDD:276965 14/62 (23%)
Kelch_1 325..372 CDD:279660 16/70 (23%)
Kelch_4 441..492 CDD:290154 11/50 (22%)
KELCH repeat 442..495 CDD:276965 11/52 (21%)
KLHDC2NP_055130.1 PLN02193 <29..296 CDD:177844 68/299 (23%)
KELCH repeat 32..91 CDD:276965 19/63 (30%)
Kelch 1 43..89 14/50 (28%)
KELCH repeat 92..138 CDD:276965 8/48 (17%)
Kelch 2 102..155 11/55 (20%)
Kelch 3 157..202 10/44 (23%)
KELCH repeat 218..265 CDD:276965 13/61 (21%)
Kelch 4 229..278 13/63 (21%)
Kelch_3 279..326 CDD:404319 11/51 (22%)
Kelch 5 280..329 12/49 (24%)
Kelch 6 331..377 4/7 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0379
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.