DRSC/TRiP Functional Genomics Resources

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Protein Alignment slim and KLHDC10

DIOPT Version :9

Sequence 1:NP_523782.1 Gene:slim / 37121 FlyBaseID:FBgn0261477 Length:609 Species:Drosophila melanogaster
Sequence 2:NP_055812.1 Gene:KLHDC10 / 23008 HGNCID:22194 Length:442 Species:Homo sapiens


Alignment Length:395 Identity:159/395 - (40%)
Similarity:213/395 - (53%) Gaps:44/395 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   195 IPGGF------PLARSGHRIIASNSHLYSLGGYNPRSAMSASRHGRCL-LFQELWSYNFATRTWR 252
            ||..|      |.||||||.:|.|::||..|||||....|........ ||:|||.|:|||..|.
Human    78 IPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWH 142

  Fly   253 LELNAGNAANMPVELASNALTIHNNVLISHGGTGYPFGVSCSNDCYV----YRTASAGATPGVDR 313
               ..|....||.||||.:|.:|.|.|:..||||.|||.|..||.:|    |:..:.        
Human   143 ---QMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWAL-------- 196

  Fly   314 LQVKGDLPTAQYGPGIVIHKHFLYTIGGTTGFDYTCDVYRLDLRTGIWENVYISRPE--MRDDPE 376
            |..:|..|:..||..:.|....||..|||||:.|:.|:::|||.|..|..:   :|.  ..|.||
Human   197 LSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQL---KPNNLSCDLPE 258

  Fly   377 GRYRHEVVYDGKHIFVLGGGTSHSVYDLQRIPAYNLEANCWDYFETYPDQRAADADDGNRGYPKP 441
            .|||||:.:||:.|::||||||.:.|.|.:|.|||||.|.|:...|.|.::.        |:|..
Human   259 ERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKI--------GFPAA 315

  Fly   442 RKCFSCVQHQSSTGDIEAFITGGLQGDFSTYFSDIWKLNLRTKHWYRIETAILPRPLYFHSAAHS 506
            |:|.||||.::     :.||.||..|:  ....|||||||:|..|.:: .|.:|.|:|||.||.:
Human   316 RRCHSCVQIKN-----DVFICGGYNGE--VILGDIWKLNLQTFQWVKL-PATMPEPVYFHCAAVT 372

  Fly   507 DNGCMYVFGGIEYIDKEMRRRNDLYKMWMTVPKLSEMCWDAITYYNDNLDLYDRKTLLEAGIPKR 571
            ..||||:.||:..| .|.:|...|:|:|:.||.|.|:.|:.:.....||....|..||..|:.:.
Human   373 PAGCMYIHGGVVNI-HENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQG 436

  Fly   572 FTERL 576
            ..|||
Human   437 LIERL 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slimNP_523782.1 KELCH repeat 203..263 CDD:276965 26/60 (43%)
KELCH repeat 267..321 CDD:276965 21/57 (37%)
KELCH repeat 324..364 CDD:276965 17/39 (44%)
Kelch_1 325..372 CDD:279660 18/48 (38%)
Kelch_4 441..492 CDD:290154 20/50 (40%)
KELCH repeat 442..495 CDD:276965 21/52 (40%)
KLHDC10NP_055812.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57
PRK14131 88..>171 CDD:237617 38/85 (45%)
KELCH repeat 92..150 CDD:276965 26/60 (43%)
Kelch 1 103..164 27/63 (43%)
PLN02153 139..>302 CDD:177814 72/176 (41%)
KELCH repeat 154..204 CDD:276965 21/57 (37%)
Kelch 2 166..217 19/58 (33%)
KELCH repeat 208..256 CDD:276965 18/50 (36%)
Kelch 3 218..270 24/54 (44%)
KELCH repeat 260..313 CDD:276965 27/60 (45%)
Kelch 4 271..319 22/55 (40%)
Kelch_1 315..361 CDD:396078 21/53 (40%)
KELCH repeat 316..362 CDD:276965 21/53 (40%)
Kelch 5 327..373 22/48 (46%)
Kelch 6 376..419 16/43 (37%)
Interaction with CUL2. /evidence=ECO:0000269|PubMed:23102700 401..442 14/41 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 64 1.000 Domainoid score I10179
eggNOG 1 0.900 - - E1_KOG0379
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H15267
Inparanoid 1 1.050 269 1.000 Inparanoid score I3026
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49432
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007461
OrthoInspector 1 1.000 - - oto90275
orthoMCL 1 0.900 - - OOG6_106219
Panther 1 1.100 - - LDO PTHR46428
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4153
SonicParanoid 1 1.000 - - X5591
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.860

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