DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slim and Y67H2A.2

DIOPT Version :9

Sequence 1:	NP_523782.1	Gene:	slim / 37121	FlyBaseID:	FBgn0261477	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001041056.1	Gene:	Y67H2A.2 / 178286	WormBaseID:	WBGene00013461	Length:	553	Species:	Caenorhabditis elegans

Alignment Length:	434	Identity:	118/434 - (27%)
Similarity:	184/434 - (42%)	Gaps:	84/434 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 WTSSSDELDEGTELSKSVLNVFLSSDKQQSQMAGQIPMYAFQPLRLVKCQYRDKHIPGGFPLARS 204
            ||..|..:..|:    |.||..:                  :|.:.|:...:|      :|::||
Worm     7 WTPFSQWMYPGS----STLNQII------------------KPFKPVEKGDQD------YPMSRS 43

  Fly   205 GHRIIASNSHLYSLGGYNPRSAMSASRHGRCLLFQELWSYNFATRTWRLELNAGNAANMPVELAS 269
            |||....|.:.|.:|||       .:...|..:|:|||:.|.||..||.....|   ..|..|||
Worm    44 GHRCFTDNEYFYVVGGY-------TTEIKRGSVFRELWAMNLATLEWRRYETKG---EFPEALAS 98

  Fly   270 NALT---IHNNVLISHGGTGYPFGVSCSNDCYVYRTASAGATPGVDRLQVKGDLPTAQYGPGI-- 329
            .||.   .::...:..||:|..||.:.||..|..|..:...|....::.|:|.||...||..|
Worm    99 FALIQVYPYSKSFLIFGGSGTMFGFTSSNSLYFLRVNNDDCTVVSHKVTVEGTLPIPLYGQAICA 163

  Fly   330 --VIHKHFLYTIGGTTGFDYTCDVYRLDLRTG----------IWENVYISRPEMRDDPEGRYRHE 382
              :..|:  |.||||.|..:..||:.|.::..          .|.:..:|:.|   ...||||.|
Worm   164 GEIPGKY--YIIGGTEGVRFNFDVHSLTMKVNPEAKHESEKFTWHSELVSQNE---GHAGRYRLE 223

  Fly   383 VVYDGKH--IFVLGGGTSHSVYDLQRIPAYNLEANCWDYFETYPDQRAADADDGNRGYPKPRKCF 445
            ..||.|.  :...|||.|..|:..::|...|:.....:..:|.||...        |:||.|:|.
Worm   224 ATYDEKTDCLLFFGGGNSREVFGFEQIVTLNIRTRETNELQTIPDVVF--------GFPKNRRCH 280

  Fly   446 SCVQHQSSTGDIEAFITGGLQGDFST------YFSDIWKLNLRTKHWYRIETAILPRPLYFHSAA 504
            :.|:...     :..|:||:  |..|      ..:::|..:|.|..|.:.: .:||..::||...
Worm   281 TLVRRGR-----KVIISGGV--DHPTTPTTAELHNNVWIFDLDTSSWEKSD-QVLPEKVFFHDTT 337

  Fly   505 HSDNGCMYVFGGIEYIDKEMRRRNDLYKMWMTVPKLSEMCWDAI 548
            .:::|.|..|||:..|.....|.|.|...|:.||:|.....:::
Worm   338 ITEDGWMLTFGGVHGIRGNAPRNNILLSSWIGVPRLQRFAIESL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slim	NP_523782.1	KELCH repeat	203..263	CDD:276965	21/59 (36%)
		KELCH repeat	267..321	CDD:276965	17/56 (30%)
		KELCH repeat	324..364	CDD:276965	14/53 (26%)
		Kelch_1	325..372	CDD:279660	16/60 (27%)
		Kelch_4	441..492	CDD:290154	12/56 (21%)
		KELCH repeat	442..495	CDD:276965	12/58 (21%)
Y67H2A.2	NP_001041056.1	KELCH repeat	42..92	CDD:276965	21/59 (36%)
		KELCH repeat	96..153	CDD:276965	17/56 (30%)
		KELCH repeat	162..212	CDD:276965	11/51 (22%)
		KELCH repeat	219..274	CDD:276965	18/62 (29%)
		KELCH repeat	277..321	CDD:276965	11/50 (22%)
		Kelch_3	286..337	CDD:290151	13/58 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15267
Inparanoid	1	1.050	140	1.000	Inparanoid score	I3073
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49432
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007461
OrthoInspector	1	1.000	-	-		oto20466
orthoMCL	1	0.900	-	-		OOG6_106219
Panther	1	1.100	-	-	LDO	PTHR46428
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4153
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.000