DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-O and Enpp1

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_445987.1	Gene:	Enpp1 / 85496	RGDID:	628825	Length:	906	Species:	Rattus norvegicus

Alignment Length:	177	Identity:	44/177 - (24%)
Similarity:	76/177 - (42%)	Gaps:	27/177 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PTTTLQRLKGLTTGSLPTFIDIGSN-FASPEINEDNIIDQIVKNDLPVVFLGDSTWTDLYPHRFK 195
            ||.|......:.||..|....|..| ...|::|....:....|.: |:.:.|...|... .|:..
  Rat   235 PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFN-PLWYKGQPIWVTA-NHQEV 297

  Fly   196 RS--YSYPSFDIFDLDSVDNEILK----HLPKE---LESKDWQVLVA----HFLGV-----DHCG 242
            ||  |.:|..|: ::|.:..:|.|    .:|.|   |...:|..|.:    ||..:     |..|
  Rat   298 RSGTYFWPGSDV-EIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSYERPHFYTLYLEEPDSSG 361

  Fly   243 HKHGPMHEEMARKLGEMNEVIRSVV-----AAMDNDTTLLVMGDHGM 284
            |.|||:..|:.:.|.:::.::..::     ..:|....|:::.||||
  Rat   362 HSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILISDHGM 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	44/177 (25%)
Enpp1	NP_445987.1	cytoplasmic tail	1..58
		transmembrane domain	59..79
		SO	86..126	CDD:197571
		cysteine-rich domain	87..168
		SO	127..170	CDD:197571
		catalytic domain	191..573		44/177 (25%)
		Phosphodiest	194..520	CDD:366747	44/177 (25%)
		Linker. /evidence=ECO:0000250\|UniProtKB:P06802	579..628
		nuclease-like domain	639..906
		NUC	657..888	CDD:214683
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900