DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and MCD4

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_012756.1	Gene:	MCD4 / 853690	SGDID:	S000001648	Length:	919	Species:	Saccharomyces cerevisiae

Alignment Length:	977	Identity:	183/977 - (18%)
Similarity:	348/977 - (35%)	Gaps:	299/977 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PQKSKVIVLVVDALKYEFGLYRANATDPLPYENKLVV--LQELLQQNP----DHARLMRFRADPP 132
            |...::.::|.|.|:.:....:  .|.|:..:.:.:.  ::.|:..|.    .|.|:       |
Yeast    46 PPAKRLFLIVGDGLRADTTFDK--VTHPVSGKTEFLAPFIRSLVMNNATYGISHTRM-------P 101

  Fly   133 TTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIV-------KNDLPVVFLGDS------ 184
            |.:......:..|.......:...:.|..:|.|:..:|..       .:.||:...|.|
Yeast   102 TESRPGHVAMIAGFYEDVSAVTKGWKSNPVNFDSFFNQSTHTYSFGSPDILPMFKDGASDPNKVD 166

  Fly   185 TWTDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLPKELES------------KDWQVLVAHFLG 237
            ||  :|.|.|: .::..|.::      |..:.:||.:...:            :|..|...|.||
Yeast   167 TW--MYDHTFE-DFTQSSIEL------DAFVFRHLDQLFHNSTLNSTLDYEIRQDGNVFFLHLLG 222

  Fly   238 VDHCGHKHGPMHEEMARKLGEMNEVIRSVVAAM-----DNDTTLLVMGDHGMTASGDHGGDTDDE 297
            .|..||.:.|...|....:..:::.|..::..:     |:.|..:...||||:|.|.||....:.
Yeast   223 CDTAGHSYRPYSAEYYDNVKYIDDQIPILIDKVNKFFADDKTAFIFTADHGMSAFGSHGDGHPNN 287

  Fly   298 TNALLFAYSK------QHRFYGNDSGSDSEML--------QQIDLVPTLATILGVPIPYSNLGLV 348
            |...|.|:..      .:.|..:|:.:::..|        :|.|:...::.::||..|.:::|
Yeast   288 TRTPLVAWGAGLNKPVHNPFPVSDNYTENWELSSIKRNDVKQADIASLMSYLIGVNYPKNSVG-- 350

  Fly   349 NFNIVPDLRVPHLN-KFQTLLLHSWQNAQQI-----------------YRYFFQYALENKRTFNV 395
                  :|.:.::: |....|...:.||:.|                 |:.:|:: :|...:..:
Yeast   351 ------ELPIAYIDGKESDKLAALYNNARSILEQYLVKQDEVIDSQFFYKEYFKF-VEKSHSHYL 408

  Fly   396 EQMD-----------HLETEFILLTHRVQ----------TVYNEVAFKSFVRDLNTNLRDILGTC 439
            |:::           :||.|.|.||..:.          |.||    ..|:|.:.|  ...:|
Yeast   409 EEIETLIQRISEGENYLEQEAITLTEELMQITLEGLHYLTTYN----WRFIRTIVT--FGFVG-- 465

  Fly   440 REIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPADFPH-IFKAKEVFYVYLINLAAGVFGYRY 503
               |:.|.        ...||..|.:..|:::.:.:...| :|.:..:...:::......|.:..
Yeast   466 ---WIFFS--------FIIFLKSFILENVIDDQKASPLSHAVFGSIGILLNWILFYQHSPFNFYM 519

  Fly   504 FKTFSFKTEEQGVIFFTAISSAVILAFHTLRHWTSIATN----WSAVKRF--GHMPTRLLLF--- 559
            :..|.        ::|                |:.|.||    .|.:|.|  |..|.:.:|.
Yeast   520 YLLFP--------LYF----------------WSYIFTNRSVLRSGIKEFFKGTSPWKRVLITIS 560

  Fly   560 ------GSMAVFFSN-SFVIQEAKILSYLLAAAILLLSHELLRL--SARLDFRTKFKASQFLRST 615
                  |.:..||.. :|.:....:..|.....:..||..:|.:  |..|...|.|.|   ::..
Yeast   561 IISVYEGIVYGFFHRWTFTLITNILAFYPFICGVRELSVNILWIITSVLLSTFTLFDA---VKIE 622

  Fly   616 ALRLILASVLAICLIRFAYTLFRCREEQGNCSDFVNTGGAGFSLKKPGTGKTYILAVVVLVVYTT 680
            .|..|..:.|.|.|..| |.|::......:.:..:      |::      :..::|.::.|.:.:
Yeast   623 DLNQIHLAGLLIILSAF-YALYKIHSRINSYTRAI------FAI------QISLVAAMLAVTHRS 674

  Fly   681 LTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLAN---SSIKHIQRTHIDAMALVIYGL 742
            :..|.||.      .||.          .|..||..|...:   ..|.|.::.:.|      |.:
Yeast   675 VISLQLRQ------GLPR----------ESQVAGWIIFFVSLFVMPILHYRKPNND------YKV 717

  Fly   743 LLVQIIVLSWAPLMTFVLPPRSSHTVTINGNESIVPEIFRKMKRMYEGDDDERRSHIPVVYGLAT 807
            .|: ||.|::||  :|::       :||:                :|.          :.|.|.|
Yeast   718 RLL-IIYLTFAP--SFII-------LTIS----------------FES----------LFYFLFT 746

  Fly   808 VYSSIVIAFGVFLALVMIVLLEPRASIGLVVCVAVGAILLSVHSILRYRTATSFESCVQPTFTAL 872
            .|              |:..:|                   :.:.::.......|:.:|....::
Yeast   747 SY--------------MVQWIE-------------------IENKIKEMKTQKDENWLQVLRVSV 778

  Fly   873 VGWFLLAHFCFFATSHQTTLSQIEWRAAFVGRTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLL 937
            :|:||| ...||.|.:..::|.....:  |.|...|....|: |||::|.       ....|.||
Yeast   779 IGFFLL-QVAFFGTGNVASISSFSLES--VCRLLPIFDPFLM-GALLMLK-------LIIPYGLL 832

  Fly   938 ST 939
            ||
Yeast   833 ST 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	63/324 (19%)
MCD4	NP_012756.1	GPI_EPT_1	46..353	CDD:293744	63/332 (19%)
MCD4	NP_012756.1	PigN	443..874	CDD:398585	104/553 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810