Protein Alignment PIG-O and LAS21

DIOPT Version :9

• Sequence 1: NP_611332.1
• Gene: PIG-O / 37118
• FlyBaseID: FBgn0034346
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_012473.1
• Gene: LAS21 / 853384
• SGDID: S000003598
• Length: 830
• Species: Saccharomyces cerevisiae
• Alignment Length: 1139
• Identity: 263/1139 - (23%)
• Similarity: 436/1139 - (38%)
• Gaps: 383/1139 - (33%)

  Fly     1 MNLTYLFVLIWLAFLISSGVMLFS---RGFLLARVSKTETSTCRRLSTNPNAEYVLTDEVVNEIF 62
            |||.. |..:..|.|::..:.:|:   |..:|..:||.:....|.|..:...:
Yeast     1 MNLKQ-FTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQ------------ 52

  Fly    63 KDVNASSNLCLPQKSKVIVLVVDALKYEFGLYRANATDPLPYENKLVVLQELLQQNPDHARLMRF 127
                           |::.:::|||:.:| |:.:..:.   :.|   |.|.|   |...|.....
Yeast    53 ---------------KLVFVIIDALRSDF-LFDSQISH---FNN---VHQWL---NTGEAWGYTS 92

  Fly   128 RADPPTTTLQRLKGLTTGSLPTFIDIGSNFA----SPEINE-DNIIDQIVKNDLPVVFLGDSTWT 187
            .|:|||.||.|||.:||||.|:|||:..|.|    |.:::| |:.:.|.::::..:.|:||.||.
Yeast    93 FANPPTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWL 157

  Fly   188 DLYPHRFKRSYSYP--SFDIFDLDSVDNEILKHLPKEL--ESKDWQVLVAHFLGVDHCGHKHGPM 248
            .|:|.:: ..::.|  ||.:.|...|||.:.::||.:|  |...|.|.:.|:||:||.|||.||.
Yeast   158 KLFPQQW-FDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPH 221

  Fly   249 HEEMARKLGEMNEVIRSVVAAM-----DNDTTLLVMGDHGMTASGDHGGDTDDETNA-LLFAYSK 307
            .:.||.|..||:.:::|:...:     |:||.:.|:|||||...|:|||.:..||:| |||...|
Yeast   222 SKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPK 286

  Fly   308 QHRFYGNDSGSD---------------SEMLQQIDLVPTLATILGVPIPYSNLGLVNFNIVPDLR 357
            ..:|...:|..:               .|.:||||:|||:|.:.|:|||.:::|:    |:||
Yeast   287 LAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGI----IIPD-- 345

  Fly   358 VPHLNKFQTLLLHSWQNAQQIYRYFFQYALENKRTFNVEQMDHLETEFILLTHRVQTVYNEVAFK 422
                                     |...|.||.....|...||   :.|..|     :.|||..
Yeast   346 -------------------------FLQLLPNKLASMKENFMHL---WKLSDH-----HGEVALD 377

  Fly   423 SF-VRDLNTNLRDILGTCREIWVRFDPTQMSQGLL-FTFLPLFFIFLVVNNSRPADFPHIFKAKE 485
            .| ..|:.|.:..|..|..:....::...::...: |..:.:..|::::..|.| ||..:..:.
Yeast   378 DFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGP-DFWQLRVSS- 440

  Fly   486 VFYVYLINLAAGVFGYRYFKTF--SFKTEEQGVIFFTAISSAVILAFHTLRHWTSIATNWSAVKR 548
             ..|.|:::..||      .||  ||..||                 |.|  |..|.|.:|||..
Yeast   441 -LSVLLVSIILGV------STFASSFIEEE-----------------HQL--WWWIVTAFSAVPL 479

  Fly   549 FGHMPTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHELLRLSARLDFRTKFKASQFLR 613
            |              |:..|..:|    :..:::.|.:                    ::.:|..
Yeast   480 F--------------VYRLNVLII----VRWFIMMACV--------------------RSIKFWN 506

  Fly   614 STALRLILASVLA----------ICLIRFAYTLFRCREEQGNCSDFVNTGGAGFSLKKPGTGKTY 668
            ::..:.|.::|::          .||....:.:             :....|||.
Yeast   507 NSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLV-------------LIMASAGFQ---------- 548

  Fly   669 ILAVVVLVVYTTLTRLYLRSCGNLTGNLPNV------LLAR--YGPTVASICAGGHILLANSSIK 725
            :|..:|..:...|...|..|...:.||...:      |||:  :.||.:::     |:||
Yeast   549 VLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNL-----IVLA----- 603

  Fly   726 HIQRTHIDAMALVIYG-LLLVQIIVLSWAPLMTFVLPPRSSHTVTINGNESIVPEIFRKMKRMYE 789
               |....|.|:|:.. |:|.::.||                    |.|     .:.:.||
Yeast   604 ---RVFFQAWAIVVISRLVLTKLKVL--------------------NKN-----YLIKDMK---- 636

  Fly   790 GDDDERRSHIPVVYGLATVYSSIVIAF-------GVFLALVMIVLLE----------PRASIGLV 837
                              ||.:|::.|       |.||   :..:||          |.||:
Yeast   637 ------------------VYITILLMFQTSSQNIGQFL---VFQILESQIFYFFQNIPTASL--- 677

  Fly   838 VCVAVGAILLSVHSILRYRTATSFESCVQPTFTALVGWFLLAHFCFFATSHQTTLSQIEWRAAFV 902
                               |:||     :..|:.||. .:|.:|.||......::|.|:...|:.
Yeast   678 -------------------TSTS-----KIYFSNLVS-LILQNFTFFQFGGTNSISTIDLGNAYH 717

  Fly   903 GRTTGIGQSNL-VSGALVILNTFCGPIFFFCMYSLLSTETFSLFALFPNLIRSCRSGGKVDASTS 966
            |.::   ..|: |.|.|:.:..|...|:               :::.|..|.......:|...|
Yeast   718 GVSS---DYNIYVVGILMSVANFAPAIY---------------WSMLPWSINYASIPAQVKLQT- 763

  Fly   967 MSDLANEAVGFDMTRGELSLYEYEDVFLGTGFKLATQFFMLQGLKIFCAMLACTIHCRHLMVWKI 1031
                        ..|.:|..:.|..:| ||                 |.|.||.:...||.:|.:
Yeast   764 ------------FIRSKLPAFTYHCIF-GT-----------------CLMTACVVLRFHLFIWSV 798

  Fly  1032 FAPRFIYEALATFVSLPALIVGYLLVLRIHRGVD 1065
            |:|:..|.....||.  .|:.|:|..|.:...:|
Yeast   799 FSPKLCYFLGWNFVM--GLLNGWLPELALLCALD 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	107/304 (35%)
LAS21	NP_012473.1	Npp1	18..610	CDD:224441	187/770 (24%)
		GPI_EPT_2	48..343	CDD:293748	107/336 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810