DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and GPI13

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_013069.1	Gene:	GPI13 / 850628	SGDID:	S000003954	Length:	1017	Species:	Saccharomyces cerevisiae

Alignment Length:	1176	Identity:	321/1176 - (27%)
Similarity:	503/1176 - (42%)	Gaps:	306/1176 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YLFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRRLSTNPNAEYVLTDEVVNEIFKDVNASS 69
            |:.:|:::|.|....:..|:|||||:|                   :|| |.:.::     |.:|
Yeast    35 YIILLVFIAILQFISIAFFTRGFLLSR-------------------HVL-DNISSQ-----NETS 74

  Fly    70 NLCLPQKSKVIVLVVDALKYEFGL--YRANATDPLPYENKLVVLQELLQQNPD-HARLMRFRADP 131
            .| .|:.:|.::||:|||:::|.:  ..:::...|.|.|.::.|.:....:.| .:.|::|.|||
Yeast    75 KL-PPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADP 138

  Fly   132 PTTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFLGDSTWTDLYPHRFKR 196
            |||||||||||||||||||||.||||....|.|||.:.|:...:..|.|.||.||..|: |.|..
Yeast   139 PTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALF-HPFLS 202

  Fly   197 SYSYP--SFDIFDLDSVDNEILKHLPKEL-ESKDWQVLVAHFLGVDHCGHKHGPMHEEMARKLGE 258
            :.|:|  |.:::|||:|||.::.:....| :.|:|.|::.|.||:||.|||:||.|..|..|..:
Yeast   203 NDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQ 267

  Fly   259 MNEVIRSVVAAMDNDTTLLVMGDHGMTASGDHGGDTDDETNALLFAYSKQHRF--------YGND 315
            :::.|..::.::|:||.|:::|||||..:|:||||:.||..:.||.|||:...        |..|
Yeast   268 VDQFIDWILKSIDDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYSKKPDMWRLKETSNYNID 332

  Fly   316 S-GSDSEMLQQIDLVPTLATILGVPIPYSNLGLVNFNIVPDLRVPHLNKFQTLLLHSWQNAQQIY 379
            : |.|...::|||||.:||.::|.|||::|||.      |...:...::..:..::|..:..|:|
Yeast   333 NLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGW------PIDEIARNDREWSQFVNSAISQLQLY 391

  Fly   380 RYFFQYALEN--------KRTFNVEQMDHLETEFILLTHRVQTVYNEVAFKSFVRDLNTNLRDIL 436
            :...|....|        |...|.......| :|:.|.|:.|.|:                   |
Yeast   392 KDTMQIHHGNDEILEPLAKNISNTPPTSDPE-KFVKLGHKYQKVF-------------------L 436

  Fly   437 GTCREIWVRFDPTQMSQG--LLFTFLPLFFIF------LVVNNSRPADFPHIFKAKEVFYVYLIN 493
            .||.|:|.:||...::.|  ||.|.|.|....      :|||...|...|.|     :..|.:.|
Yeast   437 QTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQMVPEFVPGI-----IIMVLVTN 496

  Fly   494 LA-AGVFGYRYFKTFSFKTEEQGVIFFTAISSAV---ILAFH-------TLRHWTSIATNWSAVK 547
            |. .|:| |.|.:. ||..:..|.:..|||...:   |..|.       .:|...::|..||.:
Yeast   497 LCFHGIF-YVYQQP-SFVDQFWGTLLATAIGIIIGCYITIFDRYNFIWIAMRLGETLADYWSRI- 558

  Fly   548 RFGHMPTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHELLRLSARLDFRTKFKA---- 608
                  ..:.:.....:|.||||.|.|.:|:::||:...:|..:|.:.|..|........|
Yeast   559 ------AVMFMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVFLPKRQSTTALLTATISE 617

  Fly   609 --------------SQFLRSTALRLILA---SVLAICLIRFAYTLFRCREEQGN-C-SDFVNTGG 654
                          |.:|..|....:|.   |.:.|...|.|..:..||||||. | ..|.|...
Yeast   618 KEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRLASMITICREEQGEYCIPTFNNQNN 682

  Fly   655 AG-----------FSLKKPGTG-----KTYILAVVVLV------------VYTTLTRLYLRSCGN 691
            :.           |.|....||     .:|..|..:.:            ||.:||.|...|...
Yeast   683 SSWWVLGLCFLMIFILPACITGYYNLTSSYQAAAPIWINVFLKGILGLNFVYWSLTSLENNSAVI 747

  Fly   692 LTGNLPNVLLARYGPTVASICAGGHILLANSSIKHIQRTHIDAMALVIYGLLLVQIIVLSW--AP 754
            ....|.:|.:.::  |:|.|.||..::.:|                            :.|  .|
Yeast   748 AIPFLRDVTIFKF--TLARIIAGFSLIASN----------------------------VGWLMGP 782

  Fly   755 LMTFVLPPRSSHTVTINGNESIVPEIFRKMKRMYEGDDDERRSHIPVVYGLATVYSSIVIAFGVF 819
            |           .:.:|.:.:.|                  :||...:.|...:|.|      .|
Yeast   783 L-----------CIKLNIHNTDV------------------KSHEATILGYTNIYGS------EF 812

  Fly   820 LALVMIVLL------EPRASIG-LVVCVAVGAILLSVHSILRYRTATSFESCVQPTFTALVGWFL 877
            ..||:.||:      :|.|.:. .::|..:.:| |.:..:|:.:     |:.:.|     :...|
Yeast   813 FLLVINVLISILLFNKPLAQLSYFLMCNQLLSI-LEIIDLLKLK-----ENIIGP-----IALGL 866

  Fly   878 LAHFCFFATSHQTTLSQIEWRAAFVGRTTGIGQSNLV----SGALVILNTFCGPIFFFCMYSLLS 938
            |::..||.|.||.|:..::|...|:       .|..|    :...:||||| ||.....    ||
Yeast   867 LSYQHFFTTGHQATIPSVQWDIGFM-------LSEKVTFPFTQIAIILNTF-GPHILVS----LS 919

  Fly   939 TETFSLFALFPNLIRSCRSGGKVDASTSMSDLANEAVGFDMTRGELSLYEYEDVFLGTGFKLATQ 1003
            ....:|::..|::::.....|::.::..:                  |..|..:...:.|...|.
Yeast   920 VALLTLWSQPPDVLKPQTLLGRIVSNCGI------------------LLTYNTILCLSSFIWVTH 966

  Fly  1004 FFMLQGLKIFCAMLACTIHCRHLMVWKIFAPRFIYEALATFVSLPALIVGYLLVL--RIHRGVDT 1066
            |                  .|||||||||.||||:.:|       :|||..|:|.  .|......
Yeast   967 F------------------RRHLMVWKIFCPRFIFASL-------SLIVTQLVVTFGTIAFASGR 1006

  Fly  1067 LIKRIN 1072
            |||.||
Yeast  1007 LIKHIN 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	123/289 (43%)
GPI13	NP_013069.1	Npp1	48..701	CDD:224441	222/719 (31%)
GPI13	NP_013069.1	GPI_EPT_3	77..367	CDD:293747	123/296 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345581
Domainoid	1	1.000	118	1.000	Domainoid score	I1284
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I454
Isobase	1	0.950	-	0	Normalized mean entropy	S3514
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004973
OrthoInspector	1	1.000	-	-		oto100038
orthoMCL	1	0.900	-	-		OOG6_102855
Panther	1	1.100	-	-	LDO	PTHR23071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2138
SonicParanoid	1	1.000	-	-		X3507
TreeFam	1	0.960	-	-
	14	13.730