DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and PIGO

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_116023.2	Gene:	PIGO / 84720	HGNCID:	23215	Length:	1089	Species:	Homo sapiens

Alignment Length:	1159	Identity:	362/1159 - (31%)
Similarity:	548/1159 - (47%)	Gaps:	175/1159 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRR----------LSTNPNAEYVLTDEVVNE 60
            |..|.|:.||..:|:.||:.||||.|:..|..|:|:.          ....|.|.::.:
Human     7 LLFLAWVCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMAS------ 65

  Fly    61 IFKDVNASSNLCLPQKSKVIVLVVDALKYEFGLYRAN--ATDP---LPYENKLVVLQELLQQNPD 120
                          :.|:|:::::|||:::|...:.:  ..:|   ||:..||..||.:|:..|.
Human    66 --------------RFSRVVLVLIDALRFDFAQPQHSHVPREPPVSLPFLGKLSSLQRILEIQPH 116

  Fly   121 HARLMRFRADPPTTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFLGDST 185
            ||||.|.:.||||||:||||.|||||||||||.||||||..|.|||:|.|:......|||:||.|
Human   117 HARLYRSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNLIKQLTSAGRRVVFMGDDT 181

  Fly   186 WTDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLPKELESKDWQVLVAHFLGVDHCGHKHGPMHE 250
            |.||:|..|.:::.:|||::.|||:|||.||:||...::|.:|.||:|||||||||||||||.|.
Human   182 WKDLFPGAFSKAFFFPSFNVRDLDTVDNGILEHLYPTMDSGEWDVLIAHFLGVDHCGHKHGPHHP 246

  Fly   251 EMARKLGEMNEVIRSVVAAMDNDTTLLVMGDHGMTASGDHGGDTDDETNALLFAYSKQHRFYGND 315
            |||:||.:|::||:.:|..::|||.|:|.||||||.:||||||::.|.:|.||.||.. ..:.:.
Human   247 EMAKKLSQMDQVIQGLVERLENDTLLVVAGDHGMTTNGDHGGDSELEVSAALFLYSPT-AVFPST 310

  Fly   316 SGSDSEMLQQIDLVPTLATILGVPIPYSNLGLVNFNIVPDL------RVPHLNKF-QTLLLHSWQ 373
            ...:.|::.|:.||||||.:||:|||:.|:|    .::.:|      ..||.:.. |...||  .
Human   311 PPEEPEVIPQVSLVPTLALLLGLPIPFGNIG----EVMAELFSGGEDSQPHSSALAQASALH--L 369

  Fly   374 NAQQIYRYFFQY--ALENKRTFNVEQMDHL------ETEFILLTHRVQTVYNEVAFKSFVRDLNT 430
            ||||:.|:...|  |.::.:...:.|:.:|      :.:::|.:.:..    |....:.:.:|..
Human   370 NAQQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADYQWLLQSPKGA----EATLPTVIAELQQ 430

  Fly   431 NLRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPADFPHIFKAKEVFYVYLINLA 495
            .||.....|.|.|.||...:|:.|........|...|....:....||        |...|:...
Human   431 FLRGARAMCIESWARFSLVRMAGGTALLAASCFICLLASQWAISPGFP--------FCPLLLTPV 487

  Fly   496 A----GVFGYR-YFKTFSFKTEEQGVIFFTAISSAVILAFHTLRHWTSIATNWSAVKRFGHM--- 552
            |    |...|. ...|...|.:   ::...|:::.........:.|    ..|.:.:....:
Human   488 AWGLVGAIAYAGLLGTIELKLD---LVLLGAVAAVSSFLPFLWKAW----AGWGSKRPLATLFPI 545

  Fly   553 --PTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHEL----------LRLSARLDFRTK 605
              |..|||...:|||||:|||:.||:...:||.:.||||..:|          |....||.....
Human   546 PGPVLLLLLFRLAVFFSDSFVVAEARATPFLLGSFILLLVVQLHWEGQLLPPKLLTMPRLGTSAT 610

  Fly   606 FKASQFLRSTALRLILASVLAICLIRFAYTLFRCREEQGNC--SDFVN-----TGGAGFSLKKPG 663
            ....:...:.||||.:.  |.:| .|.|....||.||...|  |.:::     .||...:|
Human   611 TNPPRHNGAYALRLGIG--LLLC-TRLAGLFHRCPEETPVCHSSPWLSPLASMVGGRAKNL---- 668

  Fly   664 TGKTYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLANSSIKHIQ 728
               .|...|..||......||:||..|||....|.:|..|:|..:.::....:..||:.:.:...
Human   669 ---WYGACVAALVALLAAVRLWLRRYGNLKSPEPPMLFVRWGLPLMALGTAAYWALASGADEAPP 730

  Fly   729 RTHI----DAMAL--VIYGLLLVQIIVLSWAPLMTF------------VLPPRSSHTVTINGNES 775
            |..:    .:|.|  .:.||....:.:|.|.|:...            ||.|.|....:....:.
Human   731 RLRVLVSGASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPFSGPPTSQADLDY 795

  Fly   776 IVPEIFRKMKRMYEGDDDERRSHIPV---VYGLATVYSSIVIAFGVFLALVMIVLLEPRASIGLV 837
            :||:|:|.|:..:.|..:..:|..|:   .|.|.:|||:.::.....||..:::|...|.|:..
Human   796 VVPQIYRHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAAMVTALTLLAFPLLLLHAERISLVF- 859

  Fly   838 VCVAVGAILLSVHS-ILRYRTATSFESCVQPTFT----ALVGWFLLAHFCFFATSHQTTLSQIEW 897
                   :||.:.| :|.:..|..........||    |:..|.|:|...|::|.||.....|.|
Human   860 -------LLLFLQSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMATQTFYSTGHQPVFPAIHW 917

  Fly   898 RAAFVGRTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLLSTETFSLFALFPNLIRSCRS----- 957
            .|||||...|.|....:...||..|||...:.|.....||        .|:|.|   |.|
Human   918 HAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPLL--------LLWPFL---CESQGLRK 971

  Fly   958 -----GGKVDASTSMSDLANEAVGFDMTRGELSLYEYEDVFLGTGFKLATQFFMLQGLKIFCAML 1017
                 |.:.||.....:.....:       |:.|.:....|.....:|..::..:.|::|....|
Human   972 RQQPPGNEADARVRPEEEEEPLM-------EMRLRDAPQHFYAALLQLGLKYLFILGIQILACAL 1029

  Fly  1018 ACTIHCRHLMVWKIFAPRFIYEALATFVSLPALIVGYLLVLRIHRGVDTLIKRI 1071
            |.:|..|||||||:|||:||:||:...||...|::|..||:|:...|.:..:::
Human  1030 AASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLGIALVMRVDGAVSSWFRQL 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	144/279 (52%)
PIGO	NP_116023.2	Npp1	42..>299	CDD:224441	127/276 (46%)
PIGO	NP_116023.2	GPI_EPT_3	65..344	CDD:293747	144/303 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156943
Domainoid	1	1.000	212	1.000	Domainoid score	I2783
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31761
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1527
Isobase	1	0.950	-	0	Normalized mean entropy	S3514
OMA	1	1.010	-	-		QHG49307
OrthoDB	1	1.010	-	-		D313125at33208
OrthoFinder	1	1.000	-	-		FOG0004973
OrthoInspector	1	1.000	-	-		oto90953
orthoMCL	1	0.900	-	-		OOG6_102855
Panther	1	1.100	-	-	LDO	PTHR23071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2138
SonicParanoid	1	1.000	-	-		X3507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750