DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and Pigo

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_064419.2	Gene:	Pigo / 56703	MGIID:	1861452	Length:	1101	Species:	Mus musculus

Alignment Length:	1161	Identity:	367/1161 - (31%)
Similarity:	558/1161 - (48%)	Gaps:	169/1161 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTYLFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRRL----------STNPNAEYVLTDEV 57
            ::.|..|.|:.||..:|:.||:.||||.|:..|..|:|:.|          ...|.|
Mouse    12 VSVLLFLAWVCFLFYAGIALFTSGFLLTRLELTNQSSCQELPGPGPLPWGSHGKPGA-------- 68

  Fly    58 VNEIFKDVNASSNLC-LPQK-SKVIVLVVDALKYEFGLYRANAT--DP---LPYENKLVVLQELL 115
                          | :|.: |:|:::::|||:::|...:.:..  :|   :|:..||..||.:|
Mouse    69 --------------CWMPSRFSRVVLVLIDALRFDFAQPQRSHVPGEPPVSVPFLGKLGSLQRIL 119

  Fly   116 QQNPDHARLMRFRADPPTTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVF 180
            :..|.|.||.|.:.||||||:||||.|||||||||||.||||||..|.|||:|.|:......|||
Mouse   120 ESQPHHGRLYRSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNVIQQLNSAGRRVVF 184

  Fly   181 LGDSTWTDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLPKELESKDWQVLVAHFLGVDHCGHKH 245
            :||.||.||:|..|.:::.:.||::.||.:|||.||:||...|:...|.||:|||||||||||||
Mouse   185 MGDDTWRDLFPGAFSQAFFFSSFNVRDLHTVDNGILEHLYPTLDGGSWDVLIAHFLGVDHCGHKH 249

  Fly   246 GPMHEEMARKLGEMNEVIRSVVAAMDNDTTLLVMGDHGMTASGDHGGDTDDETNALLFAYSKQHR 310
            ||.|.|||:||.:|::||:.::..::|||.|:|.||||||.:||||||::.|.:|.||.||.. .
Mouse   250 GPHHPEMAKKLSQMDQVIQGLIERLENDTLLVVAGDHGMTMNGDHGGDSELEVSAALFLYSPT-A 313

  Fly   311 FYGNDSGSDSEMLQQIDLVPTLATILGVPIPYSNLGLVN---FNIVPDLRVPHLNKF-QTLLLHS 371
            .:.:....:.|::.|:.||||||.:||:|||:.|.|.|.   |:...|...||.:.. |...||.
Mouse   314 LFPSVPPEEPEVIPQVSLVPTLALLLGLPIPFGNTGEVMAELFSGGSDSSHPHSSALAQVSALHI 378

  Fly   372 WQNAQQIYRYFFQYALENKRTFNVEQMDHLETEFILLTHRVQTVYNEVA--FKSFVRD------- 427
              ||||:.|:...|:... :...|:::           ||:||::::.:  ::.|:||
Mouse   379 --NAQQVSRFLHTYSAAT-QDLQVKEL-----------HRLQTLFSKASARYQHFLRDPQEAEAA 429

  Fly   428 LNT-------NLRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPADFP-HIFKAK 484
            |:|       .||.....|.|.|.||...:|:.|............|.   |:.|..| .:|:.
Mouse   430 LSTLTAEFQQFLRGARALCIESWARFSLVRMAGGAALLAAACLLCLLA---SQLAVAPGFLFRP- 490

  Fly   485 EVFYVYLINLAAGVFGYRYFKTFSFKTEEQ-GVIFFTAISSAVILAFHTLRHWTSIATN-----W 543
                :.||.:|.|:.....:...|..|..: .::...|:::|..|.....:.|.|..:.     .
Mouse   491 ----LLLIPVAWGLTWTILYAGVSVTTGSKIDLVVLGAVAAAGSLLPFLWKAWVSRGSKRPLAPL 551

  Fly   544 SAVKRFGHMPTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHEL-----------LRLS 597
            ..|.|    |..:||...:|.|||:|||:.||:...:||.:.:..|..:|           |.:|
Mouse   552 LPVPR----PVLILLLIRLATFFSDSFVVAEARATPFLLGSLVFFLVAQLHWEGQLLPPKPLTMS 612

  Fly   598 ARLDFRTKFKASQFLRSTALRLILASVLAICLIRFAYTLFRCREEQGNC--SDFVN-----TGGA 655
             ||.........:...:.||.|.:..:|   ..|.|....||.||...|  |.:::     .||.
Mouse   613 -RLGSSAPTAPPRHSGAHALWLGIGLLL---FTRLAGLFHRCPEETPACRSSPWLSPLASMVGGR 673

  Fly   656 GFSLKKPGTGKTYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLA 720
            ..:|       .|...|..||....:.||:||..|||....|.||..|:|..:..:....:..||
Mouse   674 AKNL-------WYGACVGALVALLVVVRLWLRRYGNLKSPEPPVLFVRWGMPLMVLGTAAYWALA 731

  Fly   721 NSSIKHIQRTHIDAMALV----------IYGLLLVQIIVLSWAPLMTFV------------LPPR 763
            :.:.:...|..    |||          :.||..:.:::|.|.|:...|            |.|.
Mouse   732 SGAEEAPPRLR----ALVAGASAVLPRAVMGLAALGLVLLLWRPVTVLVKAGAATSRTRTILTPF 792

  Fly   764 SSHTVTINGNESIVPEIFRKMKRMYEGDDDERRSHIPV---VYGLATVYSSIVIAFGVFLALVMI 825
            |....:....:.:||:|:|.|:..::|..:..::..|:   .|.|.:|||:.::...:.||..::
Mouse   793 SGPPTSQADLDYVVPQIYRHMQEEFQGRLERTKAQGPITVAAYQLGSVYSAAMVTALLLLAFPLM 857

  Fly   826 VLLEPRASIGLVVCVAVGAILLSVHSILRYRTATSFESCVQPTFTALVGWFLLAHFCFFATSHQT 890
            :|...|.|:..::......:||   .:|...|..:........:.|:..|.|||...|::|.||.
Mouse   858 LLHVERVSLVFLLLFLQSFLLL---HLLAAGTPVATPGPFTVLWQAVSAWVLLATQTFYSTGHQP 919

  Fly   891 TLSQIEWRAAFVGRTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLLSTETFSLFALFPNLIRSC 955
            ..|.|.|.|||||...|.|.|..:...||..|||...:.|.....||        .|:|.|..
Mouse   920 VFSAIHWHAAFVGFPDGHGSSTWLPALLVGANTFASHLLFAVGCPLL--------LLWPFLCE-- 974

  Fly   956 RSGGK----VDASTSMSDL-ANEAVGFDMTRGELSLYEYEDVFLGTGFKLATQFFMLQGLKIFCA 1015
            |.|.|    :..|.|.:.: ..|.........|:.|.:..:.|.....:|..::..:.|.:|...
Mouse   975 RQGPKRRQPLPGSESEARVRPEEEEELQEPLMEMRLRDAPNHFNAALLQLGLKYLFILGAQILAC 1039

  Fly  1016 MLACTIHCRHLMVWKIFAPRFIYEALATFVSLPALIVGYLLVLRIHRGVDTLIKRI 1071
            .||.:|..|||||||:|||:||:||:...||...|::|..||:|:...|.:..|::
Mouse  1040 ALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLGIALVMRVDVAVSSWFKKL 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	140/280 (50%)
Pigo	NP_064419.2	Npp1	50..441	CDD:224441	168/427 (39%)
Pigo	NP_064419.2	GPI_EPT_3	72..352	CDD:293747	140/280 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847346
Domainoid	1	1.000	211	1.000	Domainoid score	I2802
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31761
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1538
Isobase	1	0.950	-	0	Normalized mean entropy	S3514
OMA	1	1.010	-	-		QHG49307
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004973
OrthoInspector	1	1.000	-	-		oto94538
orthoMCL	1	0.900	-	-		OOG6_102855
Panther	1	1.100	-	-	LDO	PTHR23071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2138
SonicParanoid	1	1.000	-	-		X3507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740