Protein Alignment PIG-O and ENPP2

DIOPT Version :10

• Sequence 1: NP_611332.1
• Gene: PIG-O / 37118
• FlyBaseID: FBgn0034346
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_006716647.1
• Gene: ENPP2 / 5168
• HGNCID: 3357
• Length: 940
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 110/582 - (18%)
• Similarity: 187/582 - (32%)
• Gaps: 221/582 - (37%)

  Fly   102 LPYENKLVVLQELLQQNPDHAR--LMRFRADPPTTTLQRLKGLTTGSL-PTFIDIGSNF------ 157
            :|:|.:::.:.:.|.. |||.|  :..|.::.|.     ..|...|.. |.....||.|
Human   280 IPHERRILTILQWLTL-PDHERPSVYAFYSEQPD-----FSGHKYGPFGPEESSYGSPFTPAKRP 338

  Fly   158 --------------ASP---------------EINEDNI------IDQIV------------KND 175
                          |.|               |..:|.:      ||:||            ...
Human   339 KRKVAPKRRQERPVAPPKKRRRKIHRMDHYAAETRQDKMTNPLREIDKIVGQLMDGLKQLKLHRC 403

  Fly   176 LPVVFLGDSTWTDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLPKEL---ESK-------DWQV 230
            :.|:|:||....|:...|.:...:|       |.:||:..|  :|..|   .||       |.:.
Human   404 VNVIFVGDHGMEDVTCDRTEFLSNY-------LTNVDDITL--VPGTLGRIRSKFSNNAKYDPKA 459

  Fly   231 LVAHFLGVDHCGH------KHGP--MHEEMARKLGEMNEVI--RSVVAAMDNDT------TLLVM 279
            ::|:........|      :|.|  :|....|::.:::.::  |..||....|.      .....
Human   460 IIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQ 524

  Fly   280 GDHGMTASGDHGGDTDDETNALLFAYSKQHRFYGNDSGSDSEM--LQQIDLVPTLATILGV-PIP 341
            ||||.          |::.|::...:..    ||:.....:::  .:.|:|...:..:||: |.|
Human   525 GDHGF----------DNKVNSMQTVFVG----YGSTFKYKTKVPPFENIELYNVMCDLLGLKPAP 575

  Fly   342 YSNL-GLVNF--------------------------------------NIVPDLRVPHLNKFQTL 367
            .:.. |.:|.                                      .:.|..::..|||
Human   576 NNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNK---- 636

  Fly   368 LLHSWQNAQQIYRYFFQYALENKR----TFNVEQMDHL---------ETEFILLTHR-VQTVYNE 418
            .||:..:.:...|.|.....|||.    .|...:..||         .|.:.:|.|. .::.|:|
Human   637 RLHTKGSTEAETRKFRGSRNENKENINGNFEPRKERHLLYGRPAVLYRTRYDILYHTDFESGYSE 701

  Fly   419 VAFKSFVRDLNT-----------NLRDILGTCREIWVRFDPT------------QMSQGLLF--- 457
            :    |:..|.|           ::.|.|.:|....||..|:            |||.|.||
Human   702 I----FLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPY 762

  Fly   458 ---------------TFLPLFFIFLVVNNSRPADFPHIFKAKEVFYVYLINLAAG-VFGYRY 503
                           ..:|::..|..|.|.    |..:...|.......:|:.:| :|.|.|
Human   763 LSSSPEAKYDAFLVTNMVPMYPAFKRVWNY----FQRVLVKKYASERNGVNVISGPIFDYDY 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	64/332 (19%)
ENPP2	XP_006716647.1	SO	55..98	CDD:197571
		SO	99..142	CDD:197571
		Phosphodiest	166..530	CDD:396300	53/274 (19%)
		AslA	<330..>413	CDD:442353	14/82 (17%)
		NUC	692..922	CDD:214683	29/137 (21%)