DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and CG6790

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	1055	Identity:	210/1055 - (19%)
Similarity:	355/1055 - (33%)	Gaps:	374/1055 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLTYLFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRRLSTNPNAEYVLTD--EVVNEIFK 63
            |.|..|...:|..|.:...|     .|:|          .|||:      |.|..  :|:.|::|
  Fly     1 MKLALLQTFLWCFFSVVVNV-----SFVL----------YRRLT------YRLVGKVQVLMELWK 44

  Fly    64 D----VNASSNLCL--------------PQKS-----------KVIVLVVDALKYEFGLYRANAT 99
            .    |:....:|:              |||:           :::|.:::.|:.: .|:..|.:
  Fly    45 SKVVLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVPPAADRLVVFLLEGLRAD-TLFSDNCS 108

  Fly   100 DPLPYENKLVVLQELLQQNPDHARLMRFRADPPTTTLQRLKGLTTG--SLPTFIDIGSNFASPEI 162
            ..: |...:::.|.|:..:         :...||.|......|..|  .:|:.:        |..
  Fly   109 GAV-YIRDIILRQGLVGIS---------KTSVPTLTRSAEVALFAGFNPMPSIL--------PTS 155

  Fly   163 NEDNIIDQIVKNDLPVVFLGDSTWTDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLPKELESKD 227
            |.|.|.::.:..| ...||..|..:||.....||:.                        || |.
  Fly   156 NFDTIFNRTLAFD-KGAFLRFSHLSDLRRRLTKRAC------------------------LE-KL 194

  Fly   228 WQ----VLVAHFLGVDHCGHKHGPMHEEMARKLGEMNEVIR---SVVAAMDND--TTLLVMGDHG 283
            |.    |::.:...|...    .|:......||......||   .::.|..||  |..|....||
  Fly   195 WYANKLVMLVNLAEVGGA----SPLDIGFQMKLHNTQRNIRDAYELIEATFNDSKTAYLYTSAHG 255

  Fly   284 MTASGDHGGDTDDETNA--LLFAYSKQH--------RFYGNDSGSDSEMLQQIDLVPTLATILGV 338
            :|..|.|||.:|:|..|  ||:....:|        ....|..|.....|.||.|.|.::.::|:
  Fly   256 LTYFGSHGGGSDEEREAPFLLWGAGVKHVTENITSDFVLNNGVGMQLHKLDQIQLAPLMSALIGL 320

  Fly   339 PIPYSNLGLVNFNIVPD--LRVP--------HLNKFQTL-------------LLHSW------QN 374
            |.|.:||.     |:|.  ::|.        |||..|.|             :.|.|      .:
  Fly   321 PPPVNNLA-----ILPQGYMKVSREYARKSVHLNALQLLTQAKAIIRLHERGVFHKWLPKDKDLD 380

  Fly   375 AQQIYRYFFQYALENKRTFNVEQMDH----------LETEFILLTHRVQTVYNEVAFKSF----- 424
            .|||..|      :|       ||||          |||         .|:..:||.||.
  Fly   381 LQQIAYY------QN-------QMDHLLDMGWRSKALET---------STLAIKVALKSLKFYHN 423

  Fly   425 ---VRDLNTNLRDILGTCREIWVRFDPTQMSQGLL---------FTFLPLF----------FIFL 467
               :..:.|.:..:||     |..:...::||.::         .|:..:|          .:||
  Fly   424 YYHIPLVVTTVLALLG-----WQFYQLVKLSQNVMAPHYMRRGYLTWCTIFLASLGLLLGEMVFL 483

  Fly   468 VVNNSRPADFPHIFKAKEVFYVYLINLAAGVFGYRYFKTFSFKTEEQGVIF-------FTAISSA 525
                 :.|.|..:......|.|:.:.|||             ..:..|.||       :....:|
  Fly   484 -----QWAPFMTVICLVVPFGVWCMTLAA-------------LPQNGGWIFEPLKHLRWIVGPAA 530

  Fly   526 VILAFHTLRHWTSIATNWSAVKRFGHMPTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLS 590
            |::|        ||..|         .|..|.....:..:....::....|.|::|  |.:|||.
  Fly   531 VMIA--------SIYCN---------CPLSLAYILCVGFYNRRGWLHPSPKFLAWL--ALVLLLG 576

  Fly   591 HELLRLSARLDFRTKFKASQFLRSTALRLILASVLAICLIRFAYTLFRCREEQGNCSDFVNTGGA 655
                      .|....|..|.|.:|..|::|.::..:.:|.....|    .|......:|..||
  Fly   577 ----------GFLWSQKGMQILMTTNYRVVLQAISMLVVIVRPCVL----NENHKWKVWVINGG- 626

  Fly   656 GFSLKKPGTGKTYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLA 720
                                :::.....::|:..|.   .:|..|.|         ....:::.|
  Fly   627 --------------------ILFVAAIGIFLKEMGK---PVPLYLFA---------ANWAYLIYA 659

  Fly   721 NSSIKHIQRTHIDA-MALVIYGLLLVQIIVLSWAPLMTFVLPPRSSHTVTINGNESIVP-----E 779
            .:|:....||...: :.|:.:.||.:.:::              |...|::.....|:.     |
  Fly   660 FASVPCSSRTTPQSRLELIRFNLLTLHVLL--------------SDSYVSLFAQGLIIEYQMGLE 710

  Fly   780 IFRKMKRMYEGDDDER----RSHIPVVYGLATVYSSIVIAF-----------GVFLALVMIV-LL 828
            :..|.|   |.|:|.:    ..|:.:.|..|.   ||::.|           |.|..|.... |.
  Fly   711 VHEKFK---EADEDVKILTSSKHLQMCYRFAV---SILLYFYASLFGTGHWVGGFTYLANSARLF 769

  Fly   829 EPRASIGLV----------VCVAVGAILLSVHSILRYRTATSFES----CVQPTFTALVGWFL-- 877
            .|.:|.|||          ..:.:.|.::::.|..|.:..|.|.|    |     .|:|.:|:
  Fly   770 LPDSSSGLVPLLVLIHLLIPSIVIMASVVALSSFGRQQIRTIFSSLMLIC-----NAVVLFFVVF 829

  Fly   878 LAHFCFFATSHQTTL 892
            :.|..::..:|.:.:
  Fly   830 VPHNAYWPMAHPSVV 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	69/306 (23%)
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	67/301 (22%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	91/516 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900