DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and Pigo

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	XP_038966909.1	Gene:	Pigo / 313341	RGDID:	1309498	Length:	1128	Species:	Rattus norvegicus

Alignment Length:	1178	Identity:	364/1178 - (30%)
Similarity:	546/1178 - (46%)	Gaps:	189/1178 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTYLFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRR----------LSTNPNAEYVLTDEV 57
            ::.|..|.|:.||..:|:.||:.||||.|:..|..|:|:.          ....|.|
  Rat    25 ISVLLFLAWVCFLFYAGIALFTSGFLLTRLELTNQSSCQEPPGPGSLPWGSQGKPGA-------- 81

  Fly    58 VNEIFKDVNASSNLC-LPQK-SKVIVLVVDALKYEFGLYRANAT--DP---LPYENKLVVLQELL 115
                          | :|.: |:|:::::|||:::|...:.:..  :|   :|:..||..|:.:|
  Rat    82 --------------CWMPSRFSRVVLVLIDALRFDFAQPQCSHVPGEPPVSVPFLGKLGSLKRIL 132

  Fly   116 QQNPDHARLMRFRADPPTTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVF 180
            :..|.||||.:.:.||||||:||||.|||||||||||.||||||..|.|||:|.|:......|||
  Rat   133 EVQPHHARLYQSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNLIKQLTSAGKRVVF 197

  Fly   181 LGDSTWTDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLPKELESKDWQVLVAHFLGVDHCGHKH 245
            :||.||.||:|..|.:::.:.||::.||.:|||.||:||...::|..|.||:|||||||||||||
  Rat   198 MGDDTWKDLFPGAFSQAFFFSSFNVRDLHTVDNGILEHLYPTMDSGAWDVLIAHFLGVDHCGHKH 262

  Fly   246 GPMHEEMARKLGEMNEVIRSVVAAMDNDTTLLVMGDHGMTASGDHGGDTDDETNALLFAYSKQHR 310
            ||.|.|||:||.:|::||:.::..::|||.|:|.||||||.:||||||::.|.:|.||.||....
  Rat   263 GPHHPEMAKKLSQMDQVIQGLIERLENDTLLVVAGDHGMTMNGDHGGDSELEVSAALFLYSPTVL 327

  Fly   311 FYGNDSGSDSEMLQQIDLVPTLATILGVPIPYSNLGLVNFNIV-----------------PDLRV 358
            | .:....:.|::.||.||||||.:||:|||:.|:|.|...:.                 ||  .
  Rat   328 F-PSVPPEEPEVIPQISLVPTLALLLGLPIPFGNIGEVMAELFSGGSGGGSSRGDGDASHPD--S 389

  Fly   359 PHLNKFQTLLLHSWQNAQQIYRYFFQYALENKRTFNVEQMDHLETEFILLTHRVQTVYN-----E 418
            |.|.:...|.:    ||||:.|:...|:... :..:|:::..|:..|...:.|.|.:..     |
  Rat   390 PALAQVSALYI----NAQQVSRFLHTYSAAT-QDLHVKELRRLQELFSKASARYQHLLQHPREAE 449

  Fly   419 VAFKSFVRDLNTNLRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPADFP-HIFK 482
            .|..|...|....||.....|.|.|.||...:|:.|............|.   |:.|..| .:|:
  Rat   450 AALSSLTADFQQFLRGARAVCIESWARFSLVRMAGGAALLAAACLLCLLA---SQLAVAPGFLFR 511

  Fly   483 AKEVFYVYLINLAAGVFGYRYFKTFSFKT-EEQGVIFFTAISSAVILAFHTLRHWTSIATNWSAV 546
            .     :.||.:|.|:.....:...|..| .:...:...|:::|..|.....:.|.|    |.:.
  Rat   512 P-----LLLIPVAWGLTWTLLYAGVSVTTGSKLDPVVLGAVAAAGSLLPFLWKAWLS----WGSK 567

  Fly   547 KRFGHM-----PTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHEL----------LRL 596
            :....:     |...||...:|.|||:|||:.||:...:||.:.||.|..:|          |..
  Rat   568 RPLAPLLPVPRPVLALLLIRLATFFSDSFVVAEARATPFLLGSLILFLVAQLHWEGQLLPPKLLT 632

  Fly   597 SARLDFRTKFKASQFLRSTALRLILASVLAICLIRFAYTLFRCREEQGNC--SDFVN-----TGG 654
            ::||.........   |.:....:|..:..:...|.|....||.||...|  |.:::     .||
  Rat   633 TSRLGSSAPTAPP---RHSGTHALLLGIGLLLFTRLAGLFHRCPEETPACRSSPWLSPLASMVGG 694

  Fly   655 AGFSLKKPGTGKTYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYG-------------- 705
            ...:|       .|...|..||......||:||..|||....|.||..|:|
  Rat   695 RAKNL-------WYGACVGALVALLAAVRLWLRRYGNLKSPEPPVLFVRWGLPLMVLGTAAYWAL 752

  Fly   706 --------PTVASICAGGHILLANSSIKHIQRTHIDAMALVIYGLLLVQIIVLSWAPLMTFV--- 759
                    |.:.::.||...:|..:           .|.|...||:|     |.|.|:...|
  Rat   753 ASGAEEVPPRLRALVAGASAVLPRA-----------VMGLAASGLML-----LLWRPVTVLVKAG 801

  Fly   760 ---------LPPRSSHTVTINGNESIVPEIFRKMKRMYEGDDDERRSHIPV---VYGLATVYSSI 812
                     |.|.|....:....:.:||:|:|.|:..::|..:..|:..|:   .|.|.:|||:.
  Rat   802 AATSRTRTILTPFSGPPTSQADLDYVVPQIYRHMQEEFQGRLERTRAQGPITVAAYQLGSVYSAA 866

  Fly   813 VIAFGVFLALVMIVLLEPRASIGLVVCVAVGAILLSVHSILRYRTATSFESCVQPTFTALVGWFL 877
            ::...:.||..:::|...|.|:..::......:||   .:|...|..:........:.|:..|.|
  Rat   867 MVTALILLAFPLLLLHVERVSLVFLLLFLQSFLLL---HLLAAGTPVATPGPFTVMWQAVSAWVL 928

  Fly   878 LAHFCFFATSHQTTLSQIEWRAAFVGRTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLLSTETF 942
            ||...|::|.||...|.|.|.|||||...|.|.|..:...||..|||...:.|   .:|.|.|..
  Rat   929 LATQTFYSTGHQPVFSAIHWHAAFVGFPDGHGSSTWLPALLVGANTFASHLLF---AALSSPEAV 990

  Fly   943 S--LFALFPNLI-------RSCRSGGKVDASTSMSDLANEAVGFDMTRGELSLYEYEDVFLGTGF 998
            .  |..|:|.|.       |....|.:.:|.....:...|.:      .|:.|.:....|.....
  Rat   991 GCPLLLLWPFLCERQGPKKRQSLPGSESEARVRPEEEQEEPL------MEMRLRDAPHHFNAALL 1049

  Fly   999 KLATQFFMLQGLKIFCAMLACTIHCRHLMVWKIFAPRFIYEALATFVSLPALIVGYLLVLRIHRG 1063
            :|..::..:.|.:|....||.:|..|||||||:|||:||:||:...||...|::|..||:|:...
  Rat  1050 QLGLKYLFVLGAQILACALAASILRRHLMVWKVFAPKFIFEAIGFIVSSVGLLLGIALVMRVDGA 1114

  Fly  1064 VDTLIKRI 1071
            |.:..|::
  Rat  1115 VSSWFKKL 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	141/280 (50%)
Pigo	XP_038966909.1	GPI_EPT_3	85..365	CDD:293747	141/280 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350899
Domainoid	1	1.000	220	1.000	Domainoid score	I2550
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31761
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1467
OMA	1	1.010	-	-		QHG49307
OrthoDB	1	1.010	-	-		D313125at33208
OrthoFinder	1	1.000	-	-		FOG0004973
OrthoInspector	1	1.000	-	-		oto98049
orthoMCL	1	0.900	-	-		OOG6_102855
Panther	1	1.100	-	-	LDO	PTHR23071
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3507
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910