DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and Pign

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	XP_038946765.1	Gene:	Pign / 309051	RGDID:	1311346	Length:	939	Species:	Rattus norvegicus

Alignment Length:	1128	Identity:	216/1128 - (19%)
Similarity:	366/1128 - (32%)	Gaps:	400/1128 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PQKSKVIVLVVDALKYEFGLYR--ANATDPLPYENKLVVLQELLQQNPDHARLMRFRADPPTTTL 136
            |...::::.|.|.|:.: .||.  .:.....|:...:::.:.  .....|.|:       ||.:.
  Rat    41 PPAKRLVLFVADGLRAD-ALYELDEDGNSRAPFIRNVIMHEG--SWGVSHTRV-------PTESR 95

  Fly   137 QRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFLGDSTWT----DLYP------ 191
            .....|..|.......:...:....:..|::.::           ...||:    |:.|
  Rat    96 PGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNE-----------SKYTWSWGSPDILPMFAKGA 149

  Fly   192 ---HRFKRSYSYPS----FDIFDLDSVDNEILKHLPK------------ELESKDWQVLVAHFLG 237
               |.:  :|||.:    |...|...:|..:...:..            .:.:::..|...|.||
  Rat   150 SGDHVY--TYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFSIVNEEKVVFFLHLLG 212

  Fly   238 VDHCGHKHGPMHEEMARKLGEMNEVIRSVVAAM------DNDTTLLVMGDHGMTASGDHGGDTDD 296
            :|..||.|.|...|....:.::::.::.:|:..      |..|..:...|||||..|.||.....
  Rat   213 IDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYEDDGKTAFIFTSDHGMTDWGSHGAGHPS 277

  Fly   297 ETNALLFAYSKQHRFYGNDSGS--DSEMLQ-------------QIDLVPTLATILGVPIPYSNLG 346
            ||......:....:|..|.|..  :.|.|:             |.|:.|.:|:::|||.|.:::|
  Rat   278 ETLTPFVTWGAGIKFPQNVSAQQYEDEFLKEWRLENWKRQDINQADIAPLMASLIGVPFPLNSVG 342

  Fly   347 LVNFNIVPDLRVPHLNKFQTLLLHS-WQNAQQIYRYFFQYALENKRTFNVEQMDHLETEFILLTH 410
            :        |.|.:||........| :.||.||...|.....:.|..    .:..|.|.|.||:.
  Rat   343 I--------LPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKEA----TLPFLFTPFKLLSD 395

  Fly   411 RVQTVYNEVAFKSFVRDLNTNLRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPA 475
            ..|......| :|:::  .....|::..|.|
  Rat   396 SQQLDILRKA-RSYIK--QEKFDDVVSLCEE---------------------------------- 423

  Fly   476 DFPHIFKAKEVFYVYLINLAAGVFGYRYFKTFSFKTEEQGVIFFTAISSAVILAFHTLRHWTSIA 540
                           ||:||  :.|..|:.|:.        ..|..||.||...     .|||.|
  Rat   424 ---------------LIDLA--LRGLSYYHTYD--------RLFLGISVAVGFV-----GWTSYA 458

  Fly   541 T-----NWSAV----KRFGHMPTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHELLRL 596
            :     :.|.:    :|.|..|..||         ..||::....:..:|:..|.....:....|
  Rat   459 SLLIIKSHSDIPRGTRREGKKPHHLL---------PCSFIVAGVLVACFLMIQACPWTYYVYCLL 514

  Fly   597 SARLDFRTKFKASQFLRSTALRLILASVLAICLIRF-AYTLFRCREEQGNCSDFVNTGGAGFSLK 660
            ...:.:.. .|..:.:::     ::.|:||..|.|| ||.|
  Rat   515 PVPIWYAV-LKEREVIQA-----LVESLLAFPLSRFVAYLL------------------------ 549

  Fly   661 KPGTGKTYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLANSSIK 725
                  .:.|.:.|||    |:..|                 ||..|...|...|...|
  Rat   550 ------VFTLGIEVLV----LSFFY-----------------RYMLTAGLIVFAGWPFL------ 581

  Fly   726 HIQRTHIDAMALVIYGLLLVQIIVLSWA--PLMTFVLPPRSSHTVTINGNESIVPEIFRKMKRMY 788
                |.:...|         :|..||||  .|:..|.|              ::|.:.||
  Rat   582 ----TQLWTRA---------KITCLSWAFFSLLLAVFP--------------LMPVVGRK----- 614

  Fly   789 EGDDDERRSHIPVVYGLATVYSSIVIAFGVFLAL----VMIVLLEPRASIG----LVVCVAVGAI 845
                       |.:        |:|:..|:.:.|    |:..|::.:.::.    ||:.:.|.:.
  Rat   615 -----------PDL--------SLVMGAGLLVLLLSLAVLATLVKRKLNLVKDELLVLLLQVLST 660

  Fly   846 LLSV-------HSILRYRTATSFESCVQPTFTALVGWFLLAHFCFFATSHQTTLSQIEWRAAFVG 903
            :||:       ||:|:....        |....:|.|..||..........|.|    |:
  Rat   661 VLSMYVVYSTHHSLLKKEGL--------PLLNQIVSWATLASSLVVPLLSPTAL----WQ----- 708

  Fly   904 RTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLLSTETFSLFALFPNLIRSC------------- 955
                    .|.|..|.:::|          |.||||   ...|||| |:.||
  Rat   709 --------RLTSILLSLMST----------YLLLST---GYEALFP-LVLSCLMFVWIHVEQETL 751

  Fly   956 -RSGGKVDASTSMSDLA----NEAVGF------DMTRGELSLYEYEDVFLGTG-------FKLAT 1002
             :||  |.....::.:.    .:...|      |:.|....::.....|.|||       |.||:
  Rat   752 QQSG--VSCKQKLASIQFTYNTDITQFRQLCLDDIRRAFFLVFFLLTAFFGTGNIASINSFDLAS 814

  Fly  1003 QFFMLQGLKIFCAMLACTIHCRHLMVWKIFAPRFI-----YEAL---------ATFVSLPALIVG 1053
            .:..|.....|  |:..      ||:|||..| |:     :||:         ..|.|...::..
  Rat   815 VYCFLTVFSPF--MMGA------LMMWKILIP-FVLVMCAFEAVQITTQLSSKGIFSSWSRILAA 870

  Fly  1054 YLLVLRIHRGVDTLIKRINKAKV 1076
            .|::.::..|:....:|:.:.:|
  Rat   871 GLILEQVRSGLVKWDRRMLQKQV 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	62/326 (19%)
Pign	XP_038946765.1	GPI_EPT_1	40..345	CDD:293744	62/334 (19%)
Pign	XP_038946765.1	PigN	431..861	CDD:398585	122/615 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810