Protein Alignment PIG-O and Pign

DIOPT Version :10

• Sequence 1: NP_611332.1
• Gene: PIG-O / 37118
• FlyBaseID: FBgn0034346
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_001094054.1
• Gene: Pign / 309051
• RGDID: 1311346
• Length: 931
• Species: Rattus norvegicus
• Alignment Length: 1107
• Identity: 217/1107 - (19%)
• Similarity: 358/1107 - (32%)
• Gaps: 400/1107 - (36%)

  Fly    74 PQKSKVIVLVVDALKYEFGLYR--ANATDPLPYENKLVVLQELLQQNPDHARLMRFRADPPTTTL 136
            |...::::.|.|.|:.: .||.  .:.....|:...:::.:.  .....|.|:       ||.:.
  Rat    41 PPAKRLVLFVADGLRAD-ALYELDEDGNSRAPFIRNVIMHEG--SWGVSHTRV-------PTESR 95

  Fly   137 QRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFLGDSTWT----DLYP------ 191
            .....|..|.......:...:....:..|::.::           ...||:    |:.|
  Rat    96 PGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNE-----------SKYTWSWGSPDILPMFAKGA 149

  Fly   192 ---HRFKRSYSYPS----FDIFDLDSVDNEILKHLPK------------ELESKDWQVLVAHFLG 237
               |.:  :|||.:    |...|...:|..:...:..            .:.:::..|...|.||
  Rat   150 SGDHVY--TYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFSIVNEEKVVFFLHLLG 212

  Fly   238 VDHCGHKHGPMHEEMARKLGEMNEVIRSVVAAM------DNDTTLLVMGDHGMTASGDHGGDTDD 296
            :|..||.|.|...|....:.::::.::.:|:..      |..|..:...|||||..|.||.....
  Rat   213 IDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYEDDGKTAFIFTSDHGMTDWGSHGAGHPS 277

  Fly   297 ETNALLFAYSKQHRFYGNDSGS--DSEMLQ-------------QIDLVPTLATILGVPIPYSNLG 346
            ||......:....:|..|.|..  :.|.|:             |.|:.|.:|:::|||.|.:::|
  Rat   278 ETLTPFVTWGAGIKFPQNVSAQQYEDEFLKEWRLENWKRQDINQADIAPLMASLIGVPFPLNSVG 342

  Fly   347 LVNFNIVPDLRVPHLNKFQTLLLHS-WQNAQQIYRYFFQYALENKRTFNVEQMDHLETEFILLTH 410
            :        |.|.:||........| :.||.||...|.....:.|..    .:..|.|.|.||:.
  Rat   343 I--------LPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKEA----TLPFLFTPFKLLSD 395

  Fly   411 RVQTVYNEVAFKSFVRDLNTNLRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPA 475
            ..|......| :|:::  .....|::..|.|
  Rat   396 SQQLDILRKA-RSYIK--QEKFDDVVSLCEE---------------------------------- 423

  Fly   476 DFPHIFKAKEVFYVYLINLAAGVFGYRYFKTFSFKTEEQGVIFFTAISSAVILAFHTLRHWTSIA 540
                           ||:||  :.|..|:.|:.        ..|..||.||...     .|||.|
  Rat   424 ---------------LIDLA--LRGLSYYHTYD--------RLFLGISVAVGFV-----GWTSYA 458

  Fly   541 T-----NWSAV----KRFGHMPTRLL--LFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHELL 594
            :     :.|.:    :|.|..|..||  .|.:..|..:...:||......|:.....:.:.:.:|
  Rat   459 SLLIIKSHSDIPRGTRREGKKPHHLLPCSFIAAGVLVACFLMIQACPWTYYVYCLLPVPIWYAVL 523

  Fly   595 RLSARLDFRTKFKASQFLRSTALRLILASVLAICLIRF-AYTLFRCREEQGNCSDFVNTGGAGFS 658
            :                 ....::.::.|:||..|.|| ||.|
  Rat   524 K-----------------EREVIQALVESLLAFPLSRFVAYLL---------------------- 549

  Fly   659 LKKPGTGKTYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLANSS 723
                    .:.|.:.|||    |:..|                 ||..|...|...|...|
  Rat   550 --------VFTLGIEVLV----LSFFY-----------------RYMLTAGLIVFAGWPFL---- 581

  Fly   724 IKHIQRTHIDAMALVIYGLLLVQIIVLSWA--PLMTFVLPPRSSHTVTINGNESIVPEIFRKMKR 786
                  |.:...|         :|..||||  .|:..|.|              ::|.:.||
  Rat   582 ------TQLWTRA---------KITCLSWAFFSLLLAVFP--------------LMPVVGRK--- 614

  Fly   787 MYEGDDDERRSHIPVVYGLATVYSSIVIAFGVFLAL----VMIVLLEPRASIG----LVVCVAVG 843
                         |.:        |:|:..|:.:.|    |:..|::.:.::.    ||:.:.|.
  Rat   615 -------------PDL--------SLVMGAGLLVLLLSLAVLATLVKRKLNLVKDELLVLLLQVL 658

  Fly   844 AILLSV-------HSILRYRTATSFESCVQPTFTALVGWFLLAHFCFFATSHQTTLSQIEWRAAF 901
            :.:||:       ||:|:....        |....:|.|..||..........|.|    |:
  Rat   659 STVLSMYVVYSTHHSLLKKEGL--------PLLNQIVSWATLASSLVVPLLSPTAL----WQ--- 708

  Fly   902 VGRTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLLSTETFSLFALFPNLIRSC----------- 955
                      .|.|..|.:::|          |.||||   ...|||| |:.||
  Rat   709 ----------RLTSILLSLMST----------YLLLST---GYEALFP-LVLSCLMFVWIHVEQE 749

  Fly   956 ---RSGGKVDASTSMSDLA----NEAVGF------DMTRGELSLYEYEDVFLGTG-------FKL 1000
               :||  |.....::.:.    .:...|      |:.|....::.....|.|||       |.|
  Rat   750 TLQQSG--VSCKQKLASIQFTYNTDITQFRQLCLDDIRRAFFLVFFLLTAFFGTGNIASINSFDL 812

  Fly  1001 ATQFFMLQGLKIFCAMLACTIHCRHLMVWKIFAPRFI-----YEA--LATFVSLPALIVGYLLVL 1058
            |:.:..|.....|  |:..      ||:|||..| |:     :||  :.|.:|...|   :|:||
  Rat   813 ASVYCFLTVFSPF--MMGA------LMMWKILIP-FVLVMCAFEAVQITTQLSSKGL---FLVVL 865

  Fly  1059 RI 1060
            .|
  Rat   866 VI 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	62/326 (19%)
Pign	NP_001094054.1	GPI_EPT_1	40..345	CDD:293744	62/334 (19%)
		PigN	430..884	CDD:461508	129/629 (21%)