Protein Alignment PIG-O and PIGN

DIOPT Version :10

• Sequence 1: NP_611332.1
• Gene: PIG-O / 37118
• FlyBaseID: FBgn0034346
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_001425825.1
• Gene: PIGN / 23556
• HGNCID: 8967
• Length: 970
• Species: Homo sapiens
• Alignment Length: 1142
• Identity: 219/1142 - (19%)
• Similarity: 390/1142 - (34%)
• Gaps: 352/1142 - (30%)

  Fly    74 PQKSKVIVLVVDALKYEFGLYR--ANATDPLPYENKLVVLQELLQQNPDHARLMRFRADPPTTTL 136
            |...::::.|.|.|:.: .||.  .|.....|:...:::.:.  .....|.|:       ||.:.
Human    41 PPARRLVLFVADGLRAD-ALYELDENGNSRAPFIRNIIMHEG--SWGISHTRV-------PTESR 95

  Fly   137 QRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFLGDSTWT----DLYP------ 191
            .....|..|.......:...:....:..|::.::           ...||:    |:.|
Human    96 PGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNE-----------SKYTWSWGSPDILPMFAKGA 149

  Fly   192 ---HRFKRSYSYPS----FDIFDLDSVDNEILKHLP---------KELESK---DWQVLVAHFLG 237
               |.:  :|||.:    |...|...:|..:..::.         :.|.||   :..|...|.||
Human   150 SGDHVY--TYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLG 212

  Fly   238 VDHCGHKHGPMHEEMARKLGEMNEVIRSVVAAM------DNDTTLLVMGDHGMTASGDHGGDTDD 296
            :|..||.|.|...:....:.::::.::.:|:..      |..||.:...|||||..|.||.....
Human   213 IDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPS 277

  Fly   297 ETNALLFAYSKQHRFYGNDSGS--DSEMLQ-------------QIDLVPTLATILGVPIPYSNLG 346
            ||...|..:....::....|..  |...|:             |.|:.|.:.:::|||.|.:::|
Human   278 ETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVG 342

  Fly   347 LVNFNIVPDLRVPHLNKFQTLLLHS-WQNAQQIYRYFFQYALENKRTFNVEQMDHLETEFILLTH 410
            :        |.|.:||........| :.||.||...|.....:.|..    .:..|.|.|.||:.
Human   343 I--------LPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEV----TLPFLFTPFKLLSD 395

  Fly   411 RVQTVYNEV-AFKSFVRDLNTNLRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRP 474
            ..|  :|.: ..:|:::  :....:::..|:|
Human   396 SKQ--FNILRKARSYIK--HRKFDEVVSLCKE--------------------------------- 423

  Fly   475 ADFPHIFKAKEVFYVYLINLAAGVFGYRYFKTFS-FKTEEQGVIFFTA-ISSAVILAFHTLRHWT 537
                            ||:||  :.|..|:.|:. |......||.|.. ||.|.:|...:  |..
Human   424 ----------------LIHLA--LKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKS--HSN 468

  Fly   538 SIATNWSAVKRFGH-MPTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHELLRLSARLD 601
            .|......||:..| :|...:..|.:..||   .:||......|:.....|.:.:.:||
Human   469 LIKGVSKEVKKPSHLLPCSFVAIGILVAFF---LLIQACPWTYYVYGLLPLPIWYAVLR------ 524

  Fly   602 FRTKFKASQFLRSTALRLILASVLAICLIRF-----AYTLFRCREEQGNCSDFVNTGGAGFSLKK 661
               :|:..|.|        :.|||...|..|     |:||                   |..:..
Human   525 ---EFQVIQDL--------VVSVLTYPLSHFVGYLLAFTL-------------------GIEVLV 559

  Fly   662 PGTGKTYIL--AVVVLVVYTTLTRLYLRS-CGNLTGNLPNVLLARY--------GPTVASICAGG 715
            ......|:|  .:.....:..||||:.|: ..:|:....::|||.:        .|.::.:...|
Human   560 LSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAG 624

  Fly   716 HILL-------------ANSSIK-----HIQRTHIDAMAL-VIY----------GLLLVQIIVLS 751
            .::|             .:|.||     |:.:.....::: |:|          ||.|:..|: |
Human   625 LLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQII-S 688

  Fly   752 WAPL-MTFVLPPRSSHTVTINGNESIVPEIFRKMKRMYEGDDDERRSHIPVVYGLATVYSSIVIA 815
            ||.| .:.|:|..||            |.:|:::              ..::..|.:.|  ::::
Human   689 WATLASSLVVPLLSS------------PVLFQRL--------------FSILLSLMSTY--LLLS 725

  Fly   816 FGVFLALVMIVLLEPRASIGLVVCVAVGAILLSVHSILRYRTATSFESCVQPTFTALVGWFLLAH 880
            .| :.||..:||                :.|:.|...:...|......|.:...|::
Human   726 TG-YEALFPLVL----------------SCLMFVWINIEQETLQQSGVCCKQKLTSI-------- 765

  Fly   881 FCFFATSHQTTLSQIEW-------RAAFVG---RTTGIGQSNLVS-GALVILNTFCGPIFF--FC 932
                ..|:.|.::|...       ||.|:.   .|...|..|:.| .:..:.:.:|....|  |.
Human   766 ----QFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFM 826

  Fly   933 MYSLLSTETFSLFALFPNLIRSCRSGGKVDASTSMSDLANEAVGFDMTRGELSLYEYEDVFLGTG 997
            |.:|:..:     .|.|.::..|               |.|||.........||:.   :.|...
Human   827 MGALMMWK-----ILIPFVLVMC---------------AFEAVQLTTQLSSKSLFL---IVLVIS 868

  Fly   998 FKLATQFFMLQGLKIFCA--------MLACT------IHCRHLMVWKIFAPRF---IYEALATFV 1045
            ..:|..||.|  :|.:.:        :||||      |......:|.:..|..   :..|:...:
Human   869 DIMALHFFFL--VKDYGSWLDIGTRQLLACTAWLFMYISASPNRLWMLSDPGLDLNLLHAIRACI 931

  Fly  1046 SLPALIVGYLLVLRIHRGVDTLI--KRI---NKAKVH 1077
            |...:::...:.|....|:..|:  |::   .|.|.|
Human   932 SHYVIVMSMTIFLVFLNGLAQLLTTKKLRLCGKPKSH 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	64/326 (20%)
PIGN	NP_001425825.1	None