DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and Enpp1

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001295256.1	Gene:	Enpp1 / 18605	MGIID:	97370	Length:	906	Species:	Mus musculus

Alignment Length:	628	Identity:	111/628 - (17%)
Similarity:	202/628 - (32%)	Gaps:	192/628 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PTTTLQRLKGLTTGSLPTFIDIGSN-FASPEINEDNIIDQIVKNDLPVVFLGDSTWTDLYPHRFK 195
            ||.|......:.||..|....|..| ...|::|....:....|.: |:.:.|...|........|
Mouse   235 PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFN-PLWYKGQPIWVTANHQEVK 298

  Fly   196 R-SYSYPSFDIFDLDSVDNEILK----HLPKE---LESKDWQVLVA----HFLGV-----DHCGH 243
            . :|.:|..|: ::|.:..:|.|    .:|.|   |...:|..|.:    ||..:     |..||
Mouse   299 SGTYFWPGSDV-EIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGH 362

  Fly   244 KHGPMHEEMARKLGEMNEVIRSVV-----AAMDNDTTLLVMGDHGMTASGDHGGDTDDETNALLF 303
            .|||:..|:.:.|.:::.::..::     ..:|....|:::.||||           ::.:...:
Mouse   363 SHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGM-----------EQGSCKKY 416

  Fly   304 AYSKQHRFYGNDSGSDSEMLQQIDLVPTLATILGVPIPYSNLGLVNFN---IVPDLRV------- 358
            .|  .:::.|:.:...........|.||     .||..|     .:||   :..:|..
Mouse   417 VY--LNKYLGDVNNVKVVYGPAARLRPT-----DVPETY-----YSFNYEALAKNLSCREPNQHF 469

  Fly   359 -PHLNKFQTLLLH----------------SWQNA--------------------QQIYRYFFQYA 386
             |:|..|....||                .||.|                    ..:...|..|.
Mouse   470 RPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFIGYG 534

  Fly   387 LENKRTFNVEQMDHLETEFIL-----------------LTHRV-QTVYNE--------------- 418
            ...|....|:..:::|...::                 |.|.: :.:||.
Mouse   535 PAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNGSHGSLNHLLKKPIYNPSHPKEEGFLSQCPIK 599

  Fly   419 --------------VAFKSFVRDLNTNLRDI---------LGTCREIWVRFDPTQMSQGLLFT-- 458
                          |..|.|.:.||....|:         .|..|.:..:.....:.|....|
Mouse   600 STSNDLGCTCDPWIVPIKDFEKQLNLTTEDVDDIYHMTVPYGRPRILLKQHRVCLLQQQQFLTGY 664

  Fly   459 ----FLPLFFIFLVVNNSRPA--DFPHIFKAKEVFYVYLINLAAGVFGYRYFK-----TFSFKTE 512
                .:||:..:..::|.:.:  ||      ....|..|....:.|....|:|     ::.|.|.
Mouse   665 SLDLLMPLWASYTFLSNDQFSRDDF------SNCLYQDLRIPLSPVHKCSYYKSNSKLSYGFLTP 723

  Fly   513 EQGVIFFTAISSAVILAFHTLRHWTSIATNW-----SAVKRFGHMPTRLLL-------------F 559
            .:.......|.|..:|..:.:..:.|....|     :.::|:.|....:.:             :
Mouse   724 PRLNRVSNHIYSEALLTSNIVPMYQSFQVIWHYLHDTLLQRYAHERNGINVVSGPVFDFDYDGRY 788

  Fly   560 GSMAVFFSNSFVIQEAKIL----SYLLAAAILLLSHELLRLSA 598
            .|:.:...||.||:..:||    .:::..:...||...|..||
Mouse   789 DSLEILKQNSRVIRSQEILIPTHFFIVLTSCKQLSETPLECSA 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	50/239 (21%)
Enpp1	NP_001295256.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Di-leucine motif. /evidence=ECO:0000269\|PubMed:11598187, ECO:0000269\|PubMed:15075217	27..34
		SO	86..126	CDD:197571
		SO	127..170	CDD:197571
		Phosphodiesterase. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	173..573		66/362 (18%)
		Enpp	192..560	CDD:293742	66/349 (19%)
		Phosphodiest	194..520	CDD:279931	61/309 (20%)
		Linker. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	579..628		7/48 (15%)
		Nuclease. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	635..906		35/203 (17%)
		NUC	657..888	CDD:214683	33/181 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900