DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-O and pigo

DIOPT Version :9

Sequence 1:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001120383.1	Gene:	pigo / 100145458	XenbaseID:	XB-GENE-5945117	Length:	1088	Species:	Xenopus tropicalis

Alignment Length:	1156	Identity:	372/1156 - (32%)
Similarity:	571/1156 - (49%)	Gaps:	170/1156 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRRL-STNPNAEYVLTDEVVNEIFKDVNASS 69
            |..|.|::.|..||:.:|..||||.|:.....|:|..| |:.|..              .:....
Frog     7 LLFLAWVSILFYSGIWIFMSGFLLMRIELNNQSSCADLPSSGPQG--------------PLQQHP 57

  Fly    70 NLC-LPQK-SKVIVLVVDALKYEFGLYRANATDPLPYENKLVVLQELLQQNPDHARLMRFRADPP 132
            ..| ||:: .|.:::::|||||:|..|....|:|.||:|||.|:.:|....|.||||..||||||
Frog    58 GTCWLPRRFQKAVIIIIDALKYDFAKYEPGITNPKPYQNKLPVIHQLSTSQPRHARLYPFRADPP 122

  Fly   133 TTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFLGDSTWTDLYPHRFKRS 197
            |||:||:||:||||||||:|:||||||..|.|||:|.|:|:|...|||:||.||..|:|.:|.:|
Frog   123 TTTMQRIKGMTTGSLPTFVDVGSNFASYAIQEDNLIHQLVENGRRVVFMGDDTWDGLFPKKFFKS 187

  Fly   198 YSYPSFDIFDLDSVDNEILKHLPKELESKDWQVLVAHFLGVDHCGHKHGPMHEEMARKLGEMNEV 262
            |.:|||::.||.:|||.||:||....:|.||.|::|||||||||||||||.|.|.|.||.:||:|
Frog   188 YFFPSFNVKDLHTVDNGILQHLYPTRDSGDWDVIIAHFLGVDHCGHKHGPDHPETANKLAQMNQV 252

  Fly   263 IRSVVAAMDNDTTLLVMGDHGMTASGDHGGDTDDETNALLFAYSKQHRFYGNDSGSDSEMLQQID 327
            |.|:|..:|.:|.|||.||||||.:||||||::.|..|.||.|||...| .::...::|.:.|::
Frog   253 ISSLVEHLDEETLLLVAGDHGMTDTGDHGGDSEKEVMAALFLYSKSPLF-SHELSKEAETVPQVN 316

  Fly   328 LVPTLATILGVPIPYSNLGLVNFNIVPDL-----RVPHLNKFQTLLLHSWQNAQQIYRYFFQYAL 387
            |||||:.:||:||||||||.|    :|||     :...::...||......||.|:.|:...|:|
Frog   317 LVPTLSLLLGLPIPYSNLGAV----MPDLFSWPKKESSVSAALTLASAVHINALQVGRFLHSYSL 377

  Fly   388 ------ENKRTFNVEQMDHLETEF-ILLTHRVQTVYNEVAFKSFVRD----LNTNLRDILGTCRE 441
                  .:|.......:..|.:|: .|::.|.:..:.|..:::.:|.    :...|......|.|
Frog   378 AAGDLPSDKLRDLKSLLSSLMSEYEQLISERSRGSWTESEYENRLRQHVLRVQRYLVQARAVCME 442

  Fly   442 IWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPADFPHIFKAKEVFYVYLINLAAGVFGYRYFKT 506
            .|.||.|.:|..|...........:|........|                      ...::..|
Frog   443 SWARFHPLRMLAGCAILAATCLLCYLAAETGMALD----------------------LSCKFLLT 485

  Fly   507 FSFKTEEQGVIFFTAISSAVILAFH---TLRHWTSIATNWSAV---------------------K 547
            :.         .|..:.:..:|||.   :|..|..::. |:.|                     .
Frog   486 YP---------LFGVVGAGALLAFGKWLSLIEWDCLSL-WALVIAASQLTFFYSFRKQMQVRVRL 540

  Fly   548 RFGHM------PTRLLLF--GSMAVFFSNSFVIQEAKILSYLLAAAILLLSHELLRLSARLDF-- 602
            ||..:      |..:|:|  ||:   ||:|||:.|..:..:||.:.::|..:: |....||..
Frog   541 RFRQLSLLFSGPCLILIFRCGSL---FSDSFVVAEGHVAPFLLMSLLVLTIYK-LHWDGRLTLPT 601

  Fly   603 -------RTKFKASQ-FLRSTALRLILASVLAICLIRFAYTLFRCREEQGNCSDFVNTGGAGFSL 659
                   .||...|. :.:...:.|.|...|.:| :|.:.....||||..:|...:...... ::
Frog   602 LSPLGGDTTKLTLSTGYRKDGPILLALLGALTLC-VRLSGIFHNCREETPDCHPSLFLAPLS-NV 664

  Fly   660 KKPGTGK-TYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYG-PTVA-------SICAGG 715
            |.|.... :|:..:|.||....:.|.:|:..|||..:...||..|:| |.:|       ::.||.
Frog   665 KDPQLKNISYLGCIVCLVAIVYMVRKWLQHYGNLNSSSALVLYVRWGFPLIALAITCHWALSAGA 729

  Fly   716 HILLANSSIKHIQRTHIDAMALVIYGLLLVQIIVLSWAPLMTFVLPPRSS---HTVT----INGN 773
            ...||.  ::.:.:..:.|....:|||..:.::.|.|.|:..|:...|.|   :|||    ..|:
Frog   730 EDSLAR--LRDLIQLALVACPRAVYGLAALGLVFLLWNPVTVFMKSSRDSDADNTVTTYSGAPGS 792

  Fly   774 ES----IVPEIFRKMK-----RMYEGDDDERRSHIPVV--YGLATVYSSIVIAFGVFLALVMIVL 827
            ::    ::|:|:|||:     |:..|.|:|..:....:  |||::|||:.:|.....|.:|:::|
Frog   793 QAELLHVIPQIYRKMQRTMKSRLRHGTDEEEENKGAAIEAYGLSSVYSAAMIVTLSLLTMVLLLL 857

  Fly   828 LEPRASIGLVVCVAVGAILLSVHSILR--YRTATSFESCVQPTFTALVGWFLLAHFCFFATSHQT 890
            ...|.:...::.:....::|.:||.::  |....|.:....|.: |::.|.|.....|::|.||.
Frog   858 HSERITPAFLILLVEAFVILHIHSHVQNLYYAPDSSDQFSVPWY-AVISWALAGTQWFYSTGHQP 921

  Fly   891 TLSQIEWRAAFVGRTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLLSTETFSLFALFPNLIRSC 955
            ....|.|.:||||...| .::|:....||..|||...|.|....|||        .|:|.|   |
Frog   922 VFPAIHWNSAFVGFQEG-HENNITPAVLVAANTFSAHILFSAGSSLL--------LLWPFL---C 974

  Fly   956 RSGGKVDASTSMSDLANEAVGFDMTRGELSLYEYEDVFLGTGFKLATQFFMLQGLKIFCAMLACT 1020
            .:.||.......::        :|...|:.|.|..|.|.|...:|.|::..:||:::...:.|..
Frog   975 ETPGKKKKGKKEAE--------EMPLMEMRLRENPDKFAGALLQLGTKYLFIQGVQLLSCVCAAM 1031

  Fly  1021 IHCRHLMVWKIFAPRFIYEALATFVSLPALIVGYLLVLRIHRGVDTLIKRI 1071
            |..|||||||:|||:|::||....||...|.:|.:|:||:...|.:..|.:
Frog  1032 ILRRHLMVWKVFAPKFLFEAAGFTVSSVFLFLGIVLLLRVDSAVKSWFKSL 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	155/275 (56%)
pigo	NP_001120383.1	Npp1	57..>282	CDD:224441	129/224 (58%)
pigo	NP_001120383.1	GPI_EPT_3	63..338	CDD:293747	156/279 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	237	1.000	Domainoid score	I2283
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31761
Inparanoid	1	1.050	523	1.000	Inparanoid score	I1230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313125at33208
OrthoFinder	1	1.000	-	-		FOG0004973
OrthoInspector	1	1.000	-	-		oto104740
Panther	1	1.100	-	-	LDO	PTHR23071
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3507
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160