DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5174 and syne1

DIOPT Version :9

Sequence 1:	NP_001246407.1	Gene:	CG5174 / 37117	FlyBaseID:	FBgn0034345	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001120509.2	Gene:	syne1 / 100145637	XenbaseID:	XB-GENE-5956642	Length:	8799	Species:	Xenopus tropicalis

Alignment Length:	321	Identity:	63/321 - (19%)
Similarity:	121/321 - (37%)	Gaps:	88/321 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DWYGDGQEESEAELYLRNLTLDQIFYDVDSDYTNSLELQAVEADFIAAKLANQAPSSSMAKRFRL 103
            ||||:.:.        :.|||......||.   .::|.:....:|:   |::.....|:.|..|.
Frog  3706 DWYGEARR--------KFLTLTSDIGVVDK---TTMEKKKKNLEFL---LSDMDAGQSLLKSARE 3756

  Fly   104 KFFAKRTMRDVKVTFIDFSKPYLAKISNSDNYKRFLNIGHRSRGTKFDNTANLSEPASPANSVAS 168
            |  .:|.::.::.|..|..:   .:|::....:..|....|...|..:.|.:|
Frog  3757 K--GERVLKYLESTEADQLE---TEINSHVQRQEELTYSIRREHTALEKTFHL------------ 3804

  Fly   169 AEIAAEFAALSVEEKEQRRAEWSQELARVEEEINTLRTVLASKTRHASDLKRKLGITVWKEVTDD 233
               |.||:     :|.:::|:|..|...:      |:|.:..||                |:.:.
Frog  3805 ---AKEFS-----DKYRQQAQWLSEFQAI------LQTSVEPKT----------------ELYEK 3839

  Fly   234 VNQGLKNLKESTVYQSVEQSVGTFTKTVYEAPLYQRTESVLKSTGEKTASVFG-SITSGISSKLS 297
            ..|..|       |:|::|:|.:.             |..:|...||..::.| :..|.|..::.
Frog  3840 KAQLAK-------YKSIQQTVFSH-------------EPSIKLVIEKGEALIGVTFDSTIGERIQ 3884

  Fly   298 QMKN--SESMRSIEASVGSAYENVKVSYEHNNFMCQ-SHATKVTSRSGSVSSFPDALDENN 355
            :::.  .|....::.:|....|:||   ||:.:.|: ....|...:..|....||.::..|
Frog  3885 KLQKDFQELCILVKTTVADLEESVK---EHDEYNCELQDVEKWLLQMSSRLVAPDLMESGN 3942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5174	NP_001246407.1	TPD52	158..314	CDD:282107	27/158 (17%)
syne1	NP_001120509.2	SAC6	24..>282	CDD:227401
		SMC_prok_B	<1180..1558	CDD:274008
		SPEC	1434..1641	CDD:351773
		SPEC	1540..1751	CDD:238103
		SMC_prok_B	1715..2573	CDD:274008
		SPEC	2503..2719	CDD:238103
		SPEC	2721..2932	CDD:351773
		SPEC	3052..3263	CDD:351773
		SPEC	3268..3469	CDD:238103
		SPEC	3377..3584	CDD:351773
		SMC_prok_B	<3556..>4323	CDD:274008	63/321 (20%)
		SPEC	3804..4022	CDD:238103	39/204 (19%)
		SMC_prok_B	4256..5016	CDD:274008
		SPEC	4473..4657	CDD:351773
		SMC_prok_B	4860..5787	CDD:274008
		Smc	5922..>6716	CDD:224117
		SMC_prok_B	<5922..>6131	CDD:274008
		SPEC	6800..7025	CDD:351773
		SPEC	7028..7236	CDD:238103
		SPEC	7143..7352	CDD:351773
		SPEC	7357..7559	CDD:238103
		SPEC	7461..7672	CDD:238103
		SPEC	7789..8000	CDD:238103
		SPEC	8004..8214	CDD:238103
		SPEC	8443..8662	CDD:238103
		KASH	<8767..8799	CDD:371124
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860