DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp1 and SCP160

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_012455.1	Gene:	SCP160 / 853365	SGDID:	S000003616	Length:	1222	Species:	Saccharomyces cerevisiae

Alignment Length:	1318	Identity:	288/1318 - (21%)
Similarity:	538/1318 - (40%)	Gaps:	308/1318 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QEQVANEQQPS-------SPTSVATPTSTTSGGTGNA----------TPAFSYDDLFPALPANTS 74
            :||.|.:..||       :.|::.:|::|.|.....|          ||..|..|| |:|.:|.:
Yeast     3 EEQTAIDSPPSTVEGSVETVTTIDSPSTTASTIAATAEEHPQLEKKPTPLPSLKDL-PSLGSNAA 66

  Fly    75 AQSQSGASGSTLARVTSSQKTHIVHVPC--------KERKSTESEKF----------GEGESKRI 121
            ..:...:.|..:....|:..:.....|.        :.|.....|.|          .:.|..||
Yeast    67 FANVKVSWGPNMKPAVSNSPSPSPSAPSLTTGLGAKRMRSKNIQEAFTLDLQSQLSITKPELSRI 131

  Fly   122 CQQITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGK 186
            .|.:.|.....:|....|| :.|||:.|..:.:.:|:|:::...:...:..:.||.:....|:|.
Yeast   132 VQSVKKNHDVSVESTLSKN-ARTFLVSGVAANVHEAKRELVKKLTKPINAVIEVPSKCKASIIGS 195

  Fly   187 GGQRLREIERVTATRINIPSQSDESEF----------ITIAGTKEGIAQAEQEIRQLSAEQYKKS 241
            ||:.:|||......:||:..:.:|:.:          :::.|..|.:..|:.:|..:..|:.|.:
Yeast   196 GGRTIREISDAYEVKINVSKEVNENSYDEDMDDTTSNVSLFGDFESVNLAKAKILAIVKEETKNA 260

  Fly   242 SDRITV-PKVYHPFIVGPYSENLNKLQEETGARINVPPQQVQKD-EIVISGEKDAVAAAKAKVEA 304
            :.::.| .:.|.|:|      ::::...:.|.. .|..|..:|. :|||.|.::...|.|..::.
Yeast   261 TIKLVVEDEKYLPYI------DVSEFASDEGDE-EVKVQFYKKSGDIVILGPREKAKATKTSIQD 318

  Fly   305 IYKDMEKKCSTVSVEVAKPKHRYVIGPKGSTIAEILQLTGVSVEMP--PNDSPSETITLRGPQVA 367
            ..|.:........|::.. |.:::|..:     |:.:...|.|..|  |:|   |.::..|.:..
Yeast   319 YLKKLASNLDEEKVKIPS-KFQFLIDAE-----ELKEKYNVIVTFPSTPDD---ELVSFVGLRDK 374

  Fly   368 LGNALTVVYQKSNS----VKSVEINAAH------------WIHKYVIGRKGANMKQLEEDCPNVN 416
            :|.|:|  |.:|:|    |:|::|:.||            :..||.:      :|.|||..|||.
Yeast   375 VGEAIT--YARSSSKSYVVESLDISKAHSKNLTHAKNLIMYFTKYSV------LKGLEESHPNVK 431

  Fly   417 VN-----------CLEDKIKLEGDPENVDRAV-AYLSEIIKNYEENFTFEVMTVNPSYY----KH 465
            ::           .:...|..:.|..|..:|| ..|...:.|...:.|..:..::...:    ||
Yeast   432 ISLPSIQSLPTAETVTIHISAKSDEANDIKAVRKELISFVNNIPPSETLVITDLDYELFGGSIKH 496

  Fly   466 II------------GKAGANVNRLK--------------DELKVNINIEEREGQNNIRIEGPKEG 504
            .:            |....|.|.:.              :|::.::| :..|..|::|.:  :..
Yeast   497 CLLASESSVAFVQFGDYYPNDNSILLVALTEDEDFKPSIEEIQASLN-KANESLNSLRTK--QNN 558

  Fly   505 VRQAQLELQEKI-DKLENEKSKDVIIDRRLHRSIIGAKGEKIRE-VKDRYRQVTITIPTPQENTD 567
            :.....|..|:: |.|....|               |..:.|.| :.::...:.|.:.||:||.
Yeast   559 METKTYEFSEEVQDSLFKPSS---------------ATWKLIMEDISEQEGHLQIKLHTPEENQ- 607

  Fly   568 IVKLRGPKEDVDKCHKDLLKLVKEI-----QESSHIIEVPIFKQFHKFVIGKGGANIKKIRDETQ 627
             :.:||.    :|..|...|:.:.|     .:|...:.:|......  :||..|:|:::||::..
Yeast   608 -LTVRGD----EKAAKAANKIFESILNSPSSKSKMTVNIPANSVAR--LIGNKGSNLQQIREKFA 665

  Fly   628 TKIDLPAEGDTNE------VIVITGKKENVLEAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGT 686
            .:||:|.|.:.|.      .:.:||.:.|:..||:.:.....:.:||:|:|:.:|.|::.|:||.
Yeast   666 CQIDIPNEENNNASKDKTVEVTLTGLEYNLTHAKKYLAAEAKKWADIITKELIVPVKFHGSLIGP 730

  Fly   687 GGKLISSIMEECGGVSIKFPNSDSKSDKVTIRGPKDDVEKAKVQL-----LELANERQLASFTAE 746
            .|...:.:.|:. .|.|.||..   ::.||||||...|.||..:|     .|:.|..::.
Yeast   731 HGTYRNRLQEKY-NVFINFPRD---NEIVTIRGPSRGVNKAHEELKALLDFEMENGHKMV----- 786

  Fly   747 VRAKQQHHKFLIGKNGASIRKIRDATGARIIF------PSNEDTDKEVITIIGKEESVKKAREQL 805
            :....:|...:|||||.:|..||...|..:.|      |..::|.:..:.|.|..:::|.|.:::
Yeast   787 INVPAEHVPRIIGKNGDNINDIRAEYGVEMDFLQKSTDPKAQETGEVELEITGSRQNIKDAAKRV 851

  Fly   806 EAIIKECDEVTEGEVSVDPKHHKHFVAKRGFILHRISEECGGVMISFPRVGI-NSDK----VTIK 865
            |:|:.|..:.....:.:|.|:||..|...|.||..|..:.||..|....|.| |:|.    :|::
Yeast   852 ESIVAEASDFVTEVLKIDHKYHKSIVGSGGHILREIISKAGGEEIRNKSVDIPNADSENKDITVQ 916

  Fly   866 GAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRHHRTIMGARGFKVQQVTFEFDVQIKFPDRDAT 930
            |.:..::...:.|.:||.|.|...|..:.||......::|..|...:|:..||::.:..|::|
Yeast   917 GPQKFVKKVVEEINKIVKDAENSVTKTIDIPAERKGALIGPGGIVRRQLESEFNINLFVPNKD-- 979

  Fly   931 EPVEGLTNGGSGENGGENEGQEGEQEVEKEAEQEPVRQCDVIRITGRIEKCEAAKQALLDLI--- 992
            :|        ||:                            |.|||..|..|.|::.:|:.|
Yeast   980 DP--------SGK----------------------------ITITGAPENVEKAEKKILNEIIRE 1008

  Fly   993 PIEEELSVPFDLHRTIIGPRGANVRQFMSKHDVHVELPPSELKSDVI----------KVCGT--- 1044
            ..:.|:.||..::. .:..|||.:::......|:|....:..|::.:          ||||:
Yeast  1009 NFDREVDVPASIYE-YVSERGAFIQKLRMDLSVNVRFGNTSKKANKLARAPIEIPLEKVCGSTEG 1072

  Fly  1045 ------------------------------------------------------PARVAEAREAL 1055
                                                                  .|:..||.:..
Yeast  1073 ENAEKTKFTIEEVGAPTSSEEGDITMRLTYEPIDLSSILSDGEEKEVTKDTSNDSAKKEEALDTA 1137

  Fly  1056 VKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIGRHGAVINKLRADHDVIISLPKRDEPNDRII 1120
            ||:|::..|.........:|.  ..||...:.::|..|:.|.|:|...||||::|::.:..:.::
Yeast  1138 VKLIKERIAKAPSATYAGYVW--GADTRRFNMIVGPGGSNIKKIREAADVIINVPRKSDKVNDVV 1200

  Fly  1121 SITGYQANAEAARDAILE 1138
            .|.|.:|..|.|.:.:|:
Yeast  1201 YIRGTKAGVEKAGEMVLK 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	15/70 (21%)
		vigilin_like_KH	242..>290	CDD:239087	11/49 (22%)
		vigilin_like_KH	315..373	CDD:239087	13/59 (22%)
		vigilin_like_KH	384..440	CDD:239087	18/79 (23%)
		vigilin_like_KH	454..513	CDD:239087	11/88 (13%)
		vigilin_like_KH	524..586	CDD:239087	13/62 (21%)
		vigilin_like_KH	598..659	CDD:239087	17/66 (26%)
		vigilin_like_KH	670..732	CDD:239087	23/66 (35%)
		vigilin_like_KH	744..806	CDD:239087	17/67 (25%)
		vigilin_like_KH	817..879	CDD:239087	18/66 (27%)
		vigilin_like_KH	890..989	CDD:239087	20/98 (20%)
		vigilin_like_KH	995..1055	CDD:239087	16/126 (13%)
		vigilin_like_KH	1075..1137	CDD:239087	18/61 (30%)
		vigilin_like_KH	1149..1208	CDD:239087
SCP160	NP_012455.1	235kDa-fam	<170..>402	CDD:130673	55/249 (22%)
		KH-I_ScSCP160_rpt1	172..257	CDD:411874	17/84 (20%)
		Glyco_tranf_GTA_type	<502..>606	CDD:416254	19/121 (16%)
		KH-I_ScSCP160_rpt2	632..707	CDD:411875	18/76 (24%)
		KH-I_ScSCP160_rpt3	711..777	CDD:411876	25/69 (36%)
		KH-I_ScSCP160_rpt4	780..857	CDD:411877	20/81 (25%)
		KH-I_ScSCP160_rpt5	859..935	CDD:411878	21/75 (28%)
		KH-I_ScSCP160_rpt6	940..1008	CDD:411879	22/105 (21%)
		KH-I_ScSCP160_rpt7	1152..1218	CDD:411880	18/67 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341579
Domainoid	1	1.000	50	1.000	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I762
Isobase	1	0.950	-	0	Normalized mean entropy	S2506
OMA	1	1.010	-	-		QHG52033
OrthoFinder	1	1.000	-	-		FOG0002282
OrthoInspector	1	1.000	-	-		oto99981
orthoMCL	1	0.900	-	-		OOG6_104272
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1639
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.880