DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dp1 and YLL032C

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_013068.1	Gene:	YLL032C / 850627	SGDID:	S000003955	Length:	825	Species:	Saccharomyces cerevisiae

Alignment Length:	867	Identity:	156/867 - (17%)
Similarity:	290/867 - (33%)	Gaps:	271/867 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NATPAFSYDDLFP------------------ALPANTSAQSQSGASGSTLARV--TSSQKTHIVH 99
            |...:|..||:..                  .||.||:..:   |....:.|:  ..|:|.::..
Yeast    64 NLNASFIRDDMISIKATTDDMDLDAICRISLPLPMNTNDLT---AELEKMKRILLDLSEKFNLEL 125

  Fly   100 VPCKERKSTESEKFGEGESKRICQQITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMG 164
            :..||......|:  .||||.:|..:               .:|.|     :|.|::...::|..
Yeast   126 IITKEPAYFTPEQ--TGESKELCIYV---------------HALGF-----RSNLMECEPQLLAF 168

  Fly   165 FSTQASRQVTVPREHFRV-------------ILGKGGQRLREIERVTATRINIPSQSDESEFITI 216
            ........:|:|.:|:.:             .:|...:..:.|.|...|.|..||      .||:
Yeast   169 VDLIKKNGMTLPPQHYIIEPMELNSYSVLPLYMGVDMENFKHISRAFKTSIYAPS------LITL 227

  Fly   217 AGTKEGIAQ-------------AEQEIRQL----SAEQYKKSSDRITVPKVYHPFIVGPYSENLN 264
            :...:...|             |.:.:|:.    |...:.:....||..|:.  ||...|.:.:|
Yeast   228 SRDLKANPQIFFSGAVHSLSLLARKTLRESISVNSKSFFYRRLTNITPGKLL--FIRKYYQQKVN 290

  Fly   265 KLQEETGARINVPPQQVQKDEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTVSVEVAKPKHRYVI 329
            :|..:..:.|.|..:.::...|                           ||..:|:       ||
Yeast   291 QLILKYQSLIRVTNEYIEFQSI---------------------------STNLLEM-------VI 321

  Fly   330 GPKGSTIAEILQLTGVSVEMPPNDSPSETITL------RGPQVAL-------GNALTVVYQKSNS 381
              |..||..:.::..|.:.:..|.:.|..:.:      .|.|:.:       .|.|.||..:|::
Yeast   322 --KNFTIQVLHEIVEVQISLNENCAMSPELIIDSFFGHTGNQIVVITPKEDSFNQLIVVGNQSST 384

  Fly   382 VKSVEINAAHWIHKYVIGRK---GANMKQLEEDCPNVNVNCLEDKIKLEGDPENVDRAVAYLSEI 443
            .::.:.:..|::..:::|..   ..|::|::
Yeast   385 DEASDTSILHYLSDFIMGSNQVINPNLRQIK---------------------------------- 415

  Fly   444 IKNYEENFTFEVMTVNPSYYKHIIGKAGANVNRLKDELKVNINIEEREGQNNIRIEGPKEGVRQA 508
                      .:..::|.:...|.||....:.|:.:.....|.:|..|..:|:.:....:.....
Yeast   416 ----------AIFEIHPDFEDFISGKKNGKLTRIMELSACLIQLEMEEEDDNLYLNLVSDSFPDF 470

  Fly   509 QLELQEKIDKLENEKSKDVIIDRRLHRSIIGAKGEKIREVKDRYR---QVTITIPTPQENTDIVK 570
            :...:..|::...|:|  ..|....||.|||..|..|:....::.   |.:.:...||....:::
Yeast   471 KESFKNVINEFPAEES--FFIPEVCHRPIIGTGGSLIQATMRKHNVFIQFSNSFNLPQNKISMIR 533

  Fly   571 -----LRGP---KEDVDKCHKDLLKLVKE---------IQESS----HIIEVPIFKQFHKFVIGK 614
                 :|.|   |.::.....||.::|:|         |:.||    ||:.|    ...|.:||:
Yeast   534 YDNVIIRCPRKNKANICLAKNDLKQIVQEYDSLQSKTLIRFSSGQYRHILHV----NGQKNIIGQ 594

  Fly   615 GGANIKKIRDETQTKIDLPAEGDTNEVIVITGKKENVLEAKERIQ----------KIQNELSDIV 669
                |:| .:.....|.|....|....:.|.|..||...|...:.          ||..|:.
Yeast   595 ----IEK-NENVYIMIPLKEPLDGTSQLSIQGNDENASRAANELVNSAFGYEYEFKIDQEID--- 651

  Fly   670 TEEVQIPPK---YYNSIIGTGGKLISSIMEECGGVSIKFPNSDSKSDKVTIRGPKDDVEKAKVQL 731
                  |.|   :||.|:....::::.|        :.|     :.|.:|....||..|....:.
Yeast   652 ------PNKEYEFYNLIVVPFLQIMNII--------VTF-----EKDLITFTFEKDTNENTLTKA 697

  Fly   732 LELANERQLASFTAEVRAKQQHHKFLIGK-------------------NGASIRKIRDATGARII 777
            :||.: ..|.:...::..|:...||::|.                   |.|..|...|.|.....
Yeast   698 IELLS-NYLETQKTKIIFKKIIKKFVLGSASSKSNTSNSNTNGNFRSMNNAKSRTTIDNTSQSGA 761

  Fly   778 FPSNEDTDKEVITIIGKEESVK 799
            .|...  ...|||.:|..:::|
Yeast   762 SPQRH--KMPVITTVGGAQAIK 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	14/86 (16%)
		vigilin_like_KH	242..>290	CDD:239087	11/47 (23%)
		vigilin_like_KH	315..373	CDD:239087	13/70 (19%)
		vigilin_like_KH	384..440	CDD:239087	4/58 (7%)
		vigilin_like_KH	454..513	CDD:239087	9/58 (16%)
		vigilin_like_KH	524..586	CDD:239087	16/72 (22%)
		vigilin_like_KH	598..659	CDD:239087	15/60 (25%)
		vigilin_like_KH	670..732	CDD:239087	12/64 (19%)
		vigilin_like_KH	744..806	CDD:239087	15/75 (20%)
		vigilin_like_KH	817..879	CDD:239087
		vigilin_like_KH	890..989	CDD:239087
		vigilin_like_KH	995..1055	CDD:239087
		vigilin_like_KH	1075..1137	CDD:239087
		vigilin_like_KH	1149..1208	CDD:239087
YLL032C	NP_013068.1	COG5166	2..704	CDD:227495	140/786 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910