DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp1 and hdlbpa

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	XP_005165995.1	Gene:	hdlbpa / 794178	ZFINID:	ZDB-GENE-030131-2032	Length:	1272	Species:	Danio rerio

Alignment Length:	1316	Identity:	591/1316 - (44%)
Similarity:	868/1316 - (65%)	Gaps:	62/1316 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAAAVMEETNNATTIEQQPIALINGQEQVANEQQPSS-PTSVATPTSTTSGGTGNATPAFSYDD 64
            |.:.||:.:    .:..:....|:..|.:.|....||| ....:.||               |.|
Zfish     1 MSSVAVLTQ----ESFNEHRSGLLPEQVKAAAGGDPSSVEDDDSLPT---------------YKD 46

  Fly    65 LFPALPAN---TSAQSQSGASGSTLARVTSSQKTHIVHVPCKERKSTESEKFGEGESKRICQQIT 126
            .||.||..   ...|....|..:.:..:.||..|.:.|||.:|||..:..:||||:..::|..|.
Zfish    47 AFPPLPEKPLPEGVQETENAWTTKIKPLKSSIITQVFHVPLEERKYKDMNQFGEGDQAKVCLDIM 111

  Fly   127 KETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGKGGQRL 191
            .:|||.:|:...|:|.|:.::.||...::.||::|:....||||..|.:|:||.|.::||.|::|
Zfish   112 HKTGAHLELSMAKDQGLSIMVSGKYDAVMKARKEIVSRLQTQASATVAIPKEHHRFVIGKSGEKL 176

  Fly   192 REIERVTATRINIPSQSDESEFITIAGTKEGIAQAEQEIRQLSAEQYKKSSDRITVPKVYHPFIV 256
            :|:|..|||:|.||...|.|..|.|:|||||:.:|:.||..:||||.|::.:|:.:.||:||||.
Zfish   177 QELELKTATKIQIPRPDDPSNQIKISGTKEGLEKAKHEILLISAEQDKRAVERMNIDKVFHPFIT 241

  Fly   257 GPYSENLNKLQEETGARINVPPQQVQKDEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTVSVEVA 321
            |.:.:.:..|.:||||||||||..|.|.||||:|||:.||.|..|::.:|::.:|..:|::|||.
Zfish   242 GAHGKLVGDLMQETGARINVPPPSVNKTEIVITGEKEQVALAMVKIKKLYEEKKKNATTIAVEVK 306

  Fly   322 KPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDSPSETITLRGPQVALGNALTVVYQKSNSVKSVE 386
            |.:|:|||||||:|:.|||:.||||||:||.||.|||:.|||....||.|||.||.|:||.....
Zfish   307 KSQHKYVIGPKGNTLQEILERTGVSVEIPPLDSSSETVILRGEPARLGQALTEVYAKANSYTVSS 371

  Fly   387 INAAHWIHKYVIGRKGANMKQLEEDCPNVNVNCL--EDKIKLEGDPENVDRAVAYLSEIIKNYEE 449
            ::|..|:|:::||:||.|:.::.:..|.|::...  ||||.|||..::|......:..|:.:...
Zfish   372 VSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTKDVQIVQGQIEVIVTDLVS 436

  Fly   450 NFTFEVMTVNPSYYKHIIGKAGANVNRLKDELKVNINI-EEREGQNNIRIEGPKEGVRQAQLELQ 513
            ...:..::|:|.:::|:|||.|||:||:|:..||::.| .:.|..|.|||||..:||::|:.||.
Zfish   437 RMDYTEISVDPKFHRHLIGKGGANINRIKELHKVSVRIPPDNEKSNLIRIEGDPQGVQEAKKELL 501

  Fly   514 EKIDKLENEKSKDVIIDRRLHRSIIGAKGEKIREVKDRYRQVTITIPTPQENTDIVKLRGPKEDV 578
            |...::|||::||:||::|.||:|||.|||||:|::|::.:|.|..|.|.:.:|||:||||:.:|
Zfish   502 ELASRMENERTKDMIIEQRFHRAIIGQKGEKIKEIRDKFPEVIINFPDPAQKSDIVQLRGPRTEV 566

  Fly   579 DKCHKDLLKLVKEIQESSHIIEVPIFKQFHKFVIGKGGANIKKIRDETQTKIDLPAEGDTNEVIV 643
            :||.|.:.|:|.|:.|:|..:.|||||||||.:||||||||||||:||.||||||||...:|:||
Zfish   567 EKCSKFMQKMVAEMVENSFSVSVPIFKQFHKNIIGKGGANIKKIREETNTKIDLPAENSNSEMIV 631

  Fly   644 ITGKKENVLEAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLISSIMEECGGVSIKFPNS 708
            |||||.|...||.||..||.||::|...||.||.|.:||:||:.|:.:.|||||||||.|.||..
Zfish   632 ITGKKANCEAAKNRILAIQKELANITEVEVSIPSKLHNSLIGSKGRFVRSIMEECGGVHIHFPTE 696

  Fly   709 DSKSDKVTIRGPKDDVEKAKVQLLELANERQLASFTAEVRAKQQHHKFLIGKNGASIRKIRDATG 773
            .|..|.||||||.::|||||.|||.||.|:|..|.|.|:|||.::|||||||.|.:|||:||:||
Zfish   697 GSGIDAVTIRGPAEEVEKAKKQLLSLAEEKQTKSHTVELRAKPEYHKFLIGKGGGNIRKVRDSTG 761

  Fly   774 ARIIFPSNEDTDKEVITIIGKEESVKKAREQLEAIIKECDEVTEGEVSVDPKHHKHFVAKRGFIL 838
            ||||||:.||.|.|:||:||.||:|.:|:::|||:||..|.:.|..:.||||||:.|||:||.:|
Zfish   762 ARIIFPTAEDKDHELITVIGTEEAVAEAQKELEALIKSLDNIVEDFMIVDPKHHRFFVARRGQVL 826

  Fly   839 HRISEECGGVMISFPRVGINSDKVTIKGAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRHHRTI 903
            ..|::|.|||::||||....|||||:||||||:|||::|:.|::.||:||.|:|.||||:.||:|
Zfish   827 RDIADEYGGVIVSFPRTAAQSDKVTLKGAKDCVEAAKKRMLEMIEDLDAQVTMECVIPQKFHRSI 891

  Fly   904 MGARGFKVQQVTFEFDVQIKFPDRDATEPVEGLTNGGSGENGGENEGQEGEQEVEKEAEQEPVRQ 968
            ||.:|.::||:|.:.:||||||||:..:..:....    |||      |...||::..:....::
Zfish   892 MGPKGSRIQQITKDHNVQIKFPDREEQQQADASVQ----ENG------EANGEVKEPVDPTAPKK 946

  Fly   969 CDVIRITGRIEKCEAAKQALLDLIPIEEELSVPFDLHRTIIGPRGANVRQFMSKHDVHVELPPSE 1033
            ||||.::||.|:||||.:||..|:|:...:.|||:|||.|||.:|:.:|:.|.:.:|::::|..|
Zfish   947 CDVIVLSGRKERCEAAVEALKALVPVTIAVEVPFELHRYIIGQKGSGIRKMMDEFEVNIQVPAHE 1011

  Fly  1034 LKSDVIKVCGTPARVAEAREALVKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIGRHGAVINK 1098
            |:||:|.:.|..:.:..|:|.|::.:::.:|::.||.||||.|.:.|:.::|.|:|||.||:|:.
Zfish  1012 LQSDIISITGLASHLDRAKEGLLERVKELQAEQEDRALRSFKLTITVEPKYHPKIIGRKGAIISH 1076

  Fly  1099 LRADHDVIISLPKRDEPNDRIISITGYQANAEAARDAILEIVGDPETLHREVIEIDKRIHPHLIG 1163
            :|.||:|.|..|::::.|...|:||||:.||.||||||..||.:.|.:..|.|.:|.|:|..:||
Zfish  1077 IRHDHEVNIQFPEKNDENQDQITITGYEQNAIAARDAIQAIVDELEEMISEDITLDSRVHARIIG 1141

  Fly  1164 QRRRTIRKIIEDNKVNIKF----SADDDNPNSIFISGKIEDVENVKELLFGMAEDYERDYLDNVA 1224
            .|.:.||||:::.||:::|    :||   ||.:.::|:.|.|:...:.|..:.|:|..|.::|.|
Zfish  1142 ARGKGIRKIMDEFKVDVRFPQSGAAD---PNLVTVTGRPEHVDEAIDHLLNLEEEYMADVVENEA 1203

  Fly  1225 IAPPTIGAFLTGQGSGSDAAGASE-----NGFVIKDAPWEKQKQAKNLTAPNTQSQEDFPHFAAG 1284
            ..     |::  :.|||.|:...|     .|||:::|||    ...|..||:..|.|:||.|
Zfish  1204 KM-----AYM--KPSGSSASSMEEPRGPSKGFVVREAPW----ATGNEKAPDMSSSEEFPSF--- 1254

  Fly  1285 GAPVASTPITSVWGPK 1300
            |||||:....|.||||
Zfish  1255 GAPVAAAARASPWGPK 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	29/60 (48%)
		vigilin_like_KH	242..>290	CDD:239087	25/47 (53%)
		vigilin_like_KH	315..373	CDD:239087	36/57 (63%)
		vigilin_like_KH	384..440	CDD:239087	18/57 (32%)
		vigilin_like_KH	454..513	CDD:239087	26/59 (44%)
		vigilin_like_KH	524..586	CDD:239087	32/61 (52%)
		vigilin_like_KH	598..659	CDD:239087	43/60 (72%)
		vigilin_like_KH	670..732	CDD:239087	36/61 (59%)
		vigilin_like_KH	744..806	CDD:239087	38/61 (62%)
		vigilin_like_KH	817..879	CDD:239087	37/61 (61%)
		vigilin_like_KH	890..989	CDD:239087	41/98 (42%)
		vigilin_like_KH	995..1055	CDD:239087	22/59 (37%)
		vigilin_like_KH	1075..1137	CDD:239087	29/61 (48%)
		vigilin_like_KH	1149..1208	CDD:239087	22/62 (35%)
hdlbpa	XP_005165995.1	vigilin_like_KH	155..216	CDD:239087	29/60 (48%)
		vigilin_like_KH	227..283	CDD:239087	30/55 (55%)
		vigilin_like_KH	300..360	CDD:239087	38/59 (64%)
		vigilin_like_KH	371..428	CDD:239087	18/56 (32%)
		vigilin_like_KH	442..501	CDD:239087	26/58 (45%)
		vigilin_like_KH	512..571	CDD:239087	31/58 (53%)
		vigilin_like_KH	586..647	CDD:239087	43/60 (72%)
		vigilin_like_KH	658..720	CDD:239087	36/61 (59%)
		vigilin_like_KH	732..794	CDD:239087	38/61 (62%)
		vigilin_like_KH	808..867	CDD:239087	36/58 (62%)
		vigilin_like_KH	878..967	CDD:239087	41/98 (42%)
		vigilin_like_KH	973..1034	CDD:239087	22/60 (37%)
		vigilin_like_KH	1054..1115	CDD:239087	29/60 (48%)
		vigilin_like_KH	1126..1188	CDD:239087	22/64 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589333
Domainoid	1	1.000	89	1.000	Domainoid score	I7834
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38035
Inparanoid	1	1.050	1130	1.000	Inparanoid score	I212
OMA	1	1.010	-	-		QHG52033
OrthoDB	1	1.010	-	-		D248989at2759
OrthoFinder	1	1.000	-	-		FOG0002282
OrthoInspector	1	1.000	-	-		otm25685
orthoMCL	1	0.900	-	-		OOG6_104272
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1639
SonicParanoid	1	1.000	-	-		X2783
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940