DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp1 and hdlbpb

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	XP_021335983.1	Gene:	hdlbpb / 555414	ZFINID:	ZDB-GENE-030131-6822	Length:	1259	Species:	Danio rerio

Alignment Length:	1254	Identity:	565/1254 - (45%)
Similarity:	847/1254 - (67%)	Gaps:	47/1254 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SYDDLFPALPANTSAQSQSG---ASGSTLARVTSSQKTHIVHVPCKERKSTESEKFGEGESKRIC 122
            :|.:.||.||...|...:||   .:.|.:..:.:|..|.:.|||.:||:..::.:|||||..::|
Zfish    37 TYLEAFPPLPEKGSPGEKSGEPAGAWSKIRPIKASVITQVFHVPLEERRYKDNSQFGEGEEAKVC 101

  Fly   123 QQITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGKG 187
            ..|.::|||.||:...|:|.|:.::.||...::.||::|:....||||..|.:|:||.|.::||.
Zfish   102 LDIMQKTGAHIELSLAKDQGLSIMVTGKLDSVMKARKEIVARLQTQASATVLIPKEHHRFVIGKN 166

  Fly   188 GQRLREIERVTATRINIPSQSDESEFITIAGTKEGIAQAEQEIRQLSAEQYKKSSDRITVPKVYH 252
            |::|:|:|..|||:|.||...|.:..|.|.||||||.:|..||:.:||||.|::.:|:...|.:|
Zfish   167 GEKLQELELKTATKIAIPRSDDPNANIRITGTKEGIEKARHEIQLISAEQDKRAVERLCFEKAFH 231

  Fly   253 PFIVGPYSENLNKLQEETGARINVPPQQVQKDEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTVS 317
            |||.|.|:..:.:|.:||||||::||..:.||||||:|||:|||.|.|::.|.|::.::|.:|:|
Zfish   232 PFIAGAYNRLVQELSQETGARISIPPPSIPKDEIVITGEKEAVAMAIARIRATYEEKKRKTTTIS 296

  Fly   318 VEVAKPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDSPSETITLRGPQVALGNALTVVYQKSNSV 382
            |||.|.:|:|::||||:|:.|||:.|||||||||.||.||||.|||....||.|||.||.|:.||
Zfish   297 VEVKKSQHKYIVGPKGNTLQEILENTGVSVEMPPLDSASETIILRGEPDKLGPALTQVYAKAKSV 361

  Fly   383 KSVEINAAHWIHKYVIGRKGANMKQLEEDCPNVNVNCL--EDKIKLEGDPENVDRAVAYLSEIIK 445
            ...|:.|..|:|:::||:||.|:.::.:..|.|::...  |::|.|||..|.|::|...:.||||
Zfish   362 IVAEVIAPAWLHRFIIGKKGQNISRITQQLPKVHIEFTDGEERICLEGPTEEVEQAQIQIQEIIK 426

  Fly   446 NYEENFTFEVMTVNPSYYKHIIGKAGANVNRLKDELKVNINI-EEREGQNNIRIEGPKEGVRQAQ 509
            :......:..:.::..:::|:|||.|||:||:|::.||::.| ::.|....:||||..:||:.|:
Zfish   427 DLMVRMDYTEINIDQRFHRHLIGKNGANINRIKEQYKVSVRIPQDSERCGLVRIEGDPQGVQLAR 491

  Fly   510 LELQEKIDKLENEKSKDVIIDRRLHRSIIGAKGEKIREVKDRYRQVTITIPTPQENTDIVKLRGP 574
            .||.:...::|||::||:||:::.||:|||.|||||:||:|::.:|.|..|..|:.:|||:||||
Zfish   492 KELMDMAQRMENERTKDLIIEQKFHRTIIGQKGEKIKEVRDKFPEVIIIFPDQQQKSDIVQLRGP 556

  Fly   575 KEDVDKCHKDLLKLVKEIQESSHIIEVPIFKQFHKFVIGKGGANIKKIRDETQTKIDLPAEGDTN 639
            |.:|:||.|.|.||:.|:.|||..|.|||.|||||.:||||||||||||:||.||||||.|...:
Zfish   557 KNEVEKCAKFLQKLIAELVESSFSISVPIHKQFHKNIIGKGGANIKKIREETNTKIDLPTENSNS 621

  Fly   640 EVIVITGKKENVLEAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLISSIMEECGGVSIK 704
            |||||||||.|...|:|||..|:.||:.:...||.||.|.:||:||:.|.|:.||||:||||.|.
Zfish   622 EVIVITGKKSNCEAARERILAIEKELASMKEVEVSIPAKLHNSLIGSKGSLVRSIMEDCGGVHIH 686

  Fly   705 FPNSDSKSDKVTIRGPKDDVEKAKVQLLELANERQLASFTAEVRAKQQHHKFLIGKNGASIRKIR 769
            ||...|..|:||||||.::||:|:.|||:||.|:|:.:|:.|::||.::||:|||:.||:||::|
Zfish   687 FPAEGSGLDRVTIRGPAEEVERARKQLLQLAEEKQVNNFSVELQAKPEYHKYLIGRGGANIRRVR 751

  Fly   770 DATGARIIFPSNEDTDKEVITIIGKEESVKKAREQLEAIIKECDEVTEGEVSVDPKHHKHFVAKR 834
            |.|||||||||.:|.::|.|||:||||:|..|:.:||.:||..|:|.|..:.|:|:||:|||.:|
Zfish   752 DRTGARIIFPSADDQEQEHITIMGKEEAVILAQRELETLIKNLDDVIEDSMIVEPRHHRHFVCRR 816

  Fly   835 GFILHRISEECGGVMISFPRVGINSDKVTIKGAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRH 899
            |.:|..::||.|||.:||||.|.:||.:|:||.::|::||::||:|||.|||:|.::||:||||:
Zfish   817 GQVLRELAEEYGGVAVSFPRTGTHSDSITLKGPRECVDAAKKRIQEIVCDLESQVSMEVLIPQRY 881

  Fly   900 HRTIMGARGFKVQQVTFEFDVQIKFPDRD---ATEPVEGLTNGGSGENGGENEGQEGEQEVEKEA 961
            ||.|||.:|.::||:|.|.:|||||||||   |.||.       |.|||              :.
Zfish   882 HRAIMGPKGCRIQQITREHEVQIKFPDRDESAAQEPT-------SQENG--------------DT 925

  Fly   962 EQEPVRQCDVIRITGRIEKCEAAKQALLDLIPIEEELSVPFDLHRTIIGPRGANVRQFMSKHDVH 1026
            :..| |:||:|.:|||.||||.|:.|||.|:|:..::.|.:||||.|||.:|:.:|:.|..::|:
Zfish   926 DLTP-RKCDIITVTGRAEKCELARAALLALVPVTIDVEVSYDLHRYIIGQKGSGIRKMMEDYEVN 989

  Fly  1027 VELPPSELKSDVIKVCGTPARVAEAREALVKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIGR 1091
            :.:|..|.:||:||:.|..|.|..|:..|:..:::.:|::.||.|||:.:.:.||.::|.|:|||
Zfish   990 IWVPQPEQQSDIIKITGQVASVERAKHGLLDRVKELQAEQEDRALRSYKVTLSVDPKYHPKIIGR 1054

  Fly  1092 HGAVINKLRADHDVIISLPKRDEPNDRIISITGYQANAEAARDAILEIVGDPETLHREVIEIDKR 1156
            .||||:::|.::||.:..|.:.:....:|.|:||:.||..|:.||.::|...:.:..|.:.:|:|
Zfish  1055 KGAVISQIRKEYDVNVQFPDKGDEQQDVIVISGYERNANDAKSAIEQLVAALQEMVSEDVRLDRR 1119

  Fly  1157 IHPHLIGQRRRTIRKIIEDNKVNIKF-SADDDNPNSIFISGKIEDVENVKELLFGMAEDYERDYL 1220
            :|..:||.|.:.||||:|:.||:|:| ....::||.:.::|..|:|:|..:.|..:.|:|.....
Zfish  1120 VHARIIGARGKAIRKIMEEFKVDIRFPQPGSEDPNKVTVTGLPENVDNTIDHLLNLEEEYMLSVT 1184

  Fly  1221 DNVAIA----PPTIGAFLTGQGSGSDAAGASENGFVIKDAPWEKQKQAKNLTAPNTQSQEDFPHF 1281
            :...:|    ||   :...|.|...:...|...|||::||||    .|:...||:..|.|:||.|
Zfish  1185 ETETMAAYMKPP---SKTMGTGGNDEDNRALAKGFVVRDAPW----NAQGNKAPDVSSAEEFPTF 1242

  Fly  1282 AAGGAPVASTPITSVWGPK 1300
            .:|..|..    ||.||||
Zfish  1243 GSGITPKQ----TSAWGPK 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	29/60 (48%)
		vigilin_like_KH	242..>290	CDD:239087	23/47 (49%)
		vigilin_like_KH	315..373	CDD:239087	37/57 (65%)
		vigilin_like_KH	384..440	CDD:239087	19/57 (33%)
		vigilin_like_KH	454..513	CDD:239087	22/59 (37%)
		vigilin_like_KH	524..586	CDD:239087	33/61 (54%)
		vigilin_like_KH	598..659	CDD:239087	43/60 (72%)
		vigilin_like_KH	670..732	CDD:239087	34/61 (56%)
		vigilin_like_KH	744..806	CDD:239087	34/61 (56%)
		vigilin_like_KH	817..879	CDD:239087	30/61 (49%)
		vigilin_like_KH	890..989	CDD:239087	46/101 (46%)
		vigilin_like_KH	995..1055	CDD:239087	22/59 (37%)
		vigilin_like_KH	1075..1137	CDD:239087	23/61 (38%)
		vigilin_like_KH	1149..1208	CDD:239087	22/59 (37%)
hdlbpb	XP_021335983.1	vigilin_like_KH	149..210	CDD:239087	29/60 (48%)
		vigilin_like_KH	228..282	CDD:239087	30/53 (57%)
		vigilin_like_KH	294..354	CDD:239087	39/59 (66%)
		vigilin_like_KH	365..414	CDD:239087	17/48 (35%)
		vigilin_like_KH	436..495	CDD:239087	22/58 (38%)
		vigilin_like_KH	506..568	CDD:239087	33/61 (54%)
		vigilin_like_KH	580..641	CDD:239087	43/60 (72%)
		vigilin_like_KH	652..714	CDD:239087	34/61 (56%)
		vigilin_like_KH	726..788	CDD:239087	34/61 (56%)
		vigilin_like_KH	799..861	CDD:239087	30/61 (49%)
		vigilin_like_KH	872..945	CDD:239087	42/94 (45%)
		vigilin_like_KH	958..1019	CDD:239087	22/60 (37%)
		vigilin_like_KH	1039..1100	CDD:239087	23/60 (38%)
		vigilin_like_KH	1111..1173	CDD:239087	22/61 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589335
Domainoid	1	1.000	89	1.000	Domainoid score	I7834
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1130	1.000	Inparanoid score	I212
OMA	1	1.010	-	-		QHG52033
OrthoDB	1	1.010	-	-		D248989at2759
OrthoFinder	1	1.000	-	-		FOG0002282
OrthoInspector	1	1.000	-	-		otm25685
orthoMCL	1	0.900	-	-		OOG6_104272
Panther	1	1.100	-	-	O	PTHR10627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2783
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910