DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp1 and hdlbp

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_001006854.1	Gene:	hdlbp / 448610	XenbaseID:	XB-GENE-942331	Length:	1283	Species:	Xenopus tropicalis

Alignment Length:	1278	Identity:	604/1278 - (47%)
Similarity:	866/1278 - (67%)	Gaps:	44/1278 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QPSSPTSVATPTSTTSGGTGNA--TPAFSYDDLFPALP---ANTSAQSQSGASGSTLARVTSSQK 94
            |||....||        |.|:|  |...:|.|.||.||   .....|::...:.|.:..:.||..
Frog    21 QPSVAGHVA--------GLGSAEETDPPTYKDAFPPLPEKAVGNETQAEPVGAWSKIRPIKSSII 77

  Fly    95 THIVHVPCKERKSTESEKFGEGESKRICQQITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARR 159
            |.:.|||.:|||..:..:|||||..:||..|.::||||:|:...|:|.|:.::.||...::.||:
Frog    78 TQVFHVPLEERKYKDMAQFGEGEQAKICLDIMQKTGAQLELSLAKDQGLSIMVSGKHDSVMKARK 142

  Fly   160 KILMGFSTQASRQVTVPREHFRVILGKGGQRLREIERVTATRINIPSQSDESEFITIAGTKEGIA 224
            :|:....||||..|.:|:||.|.::||.|::|:::|..|||:|.||...:.|..|.|.||||||.
Frog   143 EIVTRLQTQASASVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPEEASNQIKITGTKEGIE 207

  Fly   225 QAEQEIRQLSAEQYKKSSDRITVPKVYHPFIVGPYSENLNKLQEETGARINVPPQQVQKDEIVIS 289
            :|..||..:||||.|::.:|:.:.|.|||||.|||::.:.::.:||..|||:||..|.|.|||.:
Frog   208 KARHEILLISAEQDKRAVERLEIEKAYHPFIAGPYNKVVTEIMQETATRINIPPPSVNKTEIVCT 272

  Fly   290 GEKDAVAAAKAKVEAIYKDMEKKCSTVSVEVAKPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDS 354
            |||:.:|.|.|:::.||::.:||.::::|||.|.:|:|||||||:.:.|||:.||||||:||:||
Frog   273 GEKEQLAQAVARIKQIYEEKKKKTTSIAVEVRKSQHKYVIGPKGNNLQEILERTGVSVEIPPSDS 337

  Fly   355 PSETITLRGPQVALGNALTVVYQKSNSVKSVEINAAHWIHKYVIGRKGANMKQLEEDCPNVNVNC 419
            .|||:.|||....||.|||.||.|:||.....::|..|:|:::||:||.|:.::.:..|.|::..
Frog   338 SSETVILRGEPEKLGQALTEVYAKANSFTVASVSAPSWLHRFIIGKKGQNLAKITQQIPKVHIEF 402

  Fly   420 L--EDKIKLEGDPENVDRAVAYLSEIIKNYEENFTFEVMTVNPSYYKHIIGKAGANVNRLKDELK 482
            .  ||||.|||..|:|..|...:..:.::......|..:.::..:::|:|||:||.:|::|::.|
Frog   403 TEGEDKISLEGPTEDVTVAQQQMEALFRDLISRMDFAEINIDHRFHRHLIGKSGAKINKIKEQYK 467

  Fly   483 VNINI-EEREGQNNIRIEGPKEGVRQAQLELQEKIDKLENEKSKDVIIDRRLHRSIIGAKGEKIR 546
            |::.| ::.|..|:|||||..:||:||:.||.|...::|||::||:||:::.||:|||.|||:||
Frog   468 VSVRIPQDSEKSNHIRIEGDPQGVQQAKKELLELASRMENERTKDLIIEQKFHRTIIGQKGERIR 532

  Fly   547 EVKDRYRQVTITIPTPQENTDIVKLRGPKEDVDKCHKDLLKLVKEIQESSHIIEVPIFKQFHKFV 611
            |:::::.:|.|..|.|.:.:|||:|||||.:|:||.|.|.|:|.|:.|:|:.|.|||||||||.:
Frog   533 EIREKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYLQKMVSELVENSYSISVPIFKQFHKNI 597

  Fly   612 IGKGGANIKKIRDETQTKIDLPAEGDTNEVIVITGKKENVLEAKERIQKIQNELSDIVTEEVQIP 676
            ||||||||||||:|..||||||||...:|:||||||:.|...|::||..||.||::|...||.||
Frog   598 IGKGGANIKKIREECNTKIDLPAENSNSEMIVITGKRPNCEAARDRILAIQKELANITELEVNIP 662

  Fly   677 PKYYNSIIGTGGKLISSIMEECGGVSIKFPNSDSKSDKVTIRGPKDDVEKAKVQLLELANERQLA 741
            .|.:||:||..|:.|.|||||||||.|.||:..|.||.||||||..|||:||.|||:||.|:|..
Frog   663 SKLHNSLIGAKGRFIRSIMEECGGVHIHFPSEGSGSDTVTIRGPVQDVERAKKQLLQLAEEKQTK 727

  Fly   742 SFTAEVRAKQQHHKFLIGKNGASIRKIRDATGARIIFPSNEDTDKEVITIIGKEESVKKAREQLE 806
            |||:|::||.::|||||||.|.:|||:||.||||||||:.:|.|:::|||:|.|:|||:|:::||
Frog   728 SFTSELKAKPEYHKFLIGKGGGNIRKVRDQTGARIIFPTADDKDQQLITIVGTEDSVKEAQKELE 792

  Fly   807 AIIKECDEVTEGEVSVDPKHHKHFVAKRGFILHRISEECGGVMISFPRVGINSDKVTIKGAKDCI 871
            .:||..|.:.|..:|||||||:|||.:||.:|..|:||.|||::||||.|:.||:||:||||:|:
Frog   793 FLIKSLDNIVEDSMSVDPKHHRHFVIRRGQVLRDIAEEYGGVIVSFPRSGVQSDRVTLKGAKECV 857

  Fly   872 EAARQRIEEIVADLEAQTTIEVVIPQRHHRTIMGARGFKVQQVTFEFDVQIKFPDRDATEPVEGL 936
            |||:::|.:|:.|||||.|||.:|.||.||:|||.:|.:|||:|.||.||||||||:.|.  :|.
Frog   858 EAAKKKILDIIEDLEAQVTIECLITQRFHRSIMGPKGIRVQQITREFGVQIKFPDREVTP--QGA 920

  Fly   937 TNGGSGENGGENEGQEGEQEVEKEAEQEPVRQCDVIRITGRIEKCEAAKQALLDLIPIEEELSVP 1001
            .|   .|...:..|.||.:  .|..:.|..::||:|.|:||.||||||..||..|:|:..|:.||
Frog   921 PN---AEPHVQENGDEGTE--VKATDPESPKKCDIILISGRKEKCEAASDALKALVPVSIEVEVP 980

  Fly  1002 FDLHRTIIGPRGANVRQFMSKHDVHVELPPSELKSDVIKVCGTPARVAEAREALVKMIEDYEADR 1066
            |||||.|||.:|:.:|:.|.:.:|::::|..|.:.|.|.:.|..|.:..|:..|::.:.:.:|::
Frog   981 FDLHRYIIGQKGSGIRKMMDEFEVNIQVPSPEQQCDTITITGQSANLDRAKAGLLERVRELQAEQ 1045

  Fly  1067 ADRELRSFVLQVDVDTEFHSKLIGRHGAVINKLRADHDVIISLP-KRDEPNDRIISITGYQANAE 1130
            .||.||||.|.|.||.:||.|:|||.||||:.:|:||||.|..| |.||..|:|| ||||:.|.|
Frog  1046 EDRALRSFKLAVSVDPKFHPKIIGRKGAVISLIRSDHDVNIQFPDKNDENQDQII-ITGYERNTE 1109

  Fly  1131 AARDAILEIVGDPETLHREVIEIDKRIHPHLIGQRRRTIRKIIEDNKVNIKF---SADDDNPNSI 1192
            :||||||.||||.|.:..|.|.:|.|:|..:||.|.:.||||:::.||:|:|   .|.|  ||.:
Frog  1110 SARDAILHIVGDLEKMVSEDITVDHRVHARIIGARGKAIRKIMDEFKVDIRFPQTGAPD--PNLV 1172

  Fly  1193 FISGKIEDVENVKELLFGMAEDYERDYLDNVAIAPPTIGAFLTGQGSGSDAAGASENGFVIKDAP 1257
            .::||.|||:...:.|..:.|:|..|.:||     ..:.:::... |..::......|||::|||
Frog  1173 TVTGKPEDVDEAIDHLLNLEEEYMSDVVDN-----EVMQSYMKPH-SHEESKSQPSKGFVVRDAP 1231

  Fly  1258 WEKQKQAKNLTAPNTQSQEDFPHFAAGGAPVASTPITSVWGPK 1300
            |   ....|..||:..|.||||.|   |.|||..  ||.||||
Frog  1232 W---TTGSNEKAPDMSSSEDFPIF---GTPVAHK--TSPWGPK 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	28/60 (47%)
		vigilin_like_KH	242..>290	CDD:239087	22/47 (47%)
		vigilin_like_KH	315..373	CDD:239087	34/57 (60%)
		vigilin_like_KH	384..440	CDD:239087	20/57 (35%)
		vigilin_like_KH	454..513	CDD:239087	23/59 (39%)
		vigilin_like_KH	524..586	CDD:239087	31/61 (51%)
		vigilin_like_KH	598..659	CDD:239087	41/60 (68%)
		vigilin_like_KH	670..732	CDD:239087	38/61 (62%)
		vigilin_like_KH	744..806	CDD:239087	36/61 (59%)
		vigilin_like_KH	817..879	CDD:239087	37/61 (61%)
		vigilin_like_KH	890..989	CDD:239087	48/98 (49%)
		vigilin_like_KH	995..1055	CDD:239087	22/59 (37%)
		vigilin_like_KH	1075..1137	CDD:239087	37/62 (60%)
		vigilin_like_KH	1149..1208	CDD:239087	25/61 (41%)
hdlbp	NP_001006854.1	vigilin_like_KH	153..214	CDD:239087	28/60 (47%)
		vigilin_like_KH	225..286	CDD:239087	28/60 (47%)
		vigilin_like_KH	298..358	CDD:239087	36/59 (61%)
		vigilin_like_KH	369..426	CDD:239087	20/56 (36%)
		vigilin_like_KH	440..499	CDD:239087	23/58 (40%)
		vigilin_like_KH	510..572	CDD:239087	31/61 (51%)
		vigilin_like_KH	584..645	CDD:239087	41/60 (68%)
		vigilin_like_KH	656..718	CDD:239087	38/61 (62%)
		vigilin_like_KH	730..792	CDD:239087	36/61 (59%)
		vigilin_like_KH	803..865	CDD:239087	37/61 (61%)
		vigilin_like_KH	876..968	CDD:239087	48/98 (49%)
		vigilin_like_KH	974..1035	CDD:239087	22/60 (37%)
		vigilin_like_KH	1057..1116	CDD:239087	36/59 (61%)
		vigilin_like_KH	1127..1189	CDD:239087	25/63 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7774
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38035
Inparanoid	1	1.050	1157	1.000	Inparanoid score	I206
OMA	1	1.010	-	-		QHG52033
OrthoDB	1	1.010	-	-		D248989at2759
OrthoFinder	1	1.000	-	-		FOG0002282
OrthoInspector	1	1.000	-	-		oto104617
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2783
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080