DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dp1 and HDLBP

DIOPT Version :9

Sequence 1:NP_001286573.1 Gene:Dp1 / 37116 FlyBaseID:FBgn0027835 Length:1301 Species:Drosophila melanogaster
Sequence 2:NP_001307894.1 Gene:HDLBP / 3069 HGNCID:4857 Length:1268 Species:Homo sapiens


Alignment Length:1323 Identity:614/1323 - (46%)
Similarity:884/1323 - (66%) Gaps:79/1323 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQAAAVMEETNNATTIEQQPIALINGQEQVA--NEQQPSSPTSVATPTSTTSGGTGNATPAFSYD 63
            |.:.||:.:.:.|    :....|:..|.:||  |.::.|.|     ||               |.
Human     1 MSSVAVLTQESFA----EHRSGLVPQQIKVATLNSEEESDP-----PT---------------YK 41

  Fly    64 DLFPALPANT----SAQSQSGASGSTLARVTSSQKTHIVHVPCKERKSTESEKFGEGESKRICQQ 124
            |.||.||...    |||..:||.|:.:..:.:|..|.:.|||.:|||..:..:|||||..:||.:
Human    42 DAFPPLPEKAACLESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLE 106

  Fly   125 ITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGKGGQ 189
            |.:.|||.:|:...|:|.|:.::.||...::.||:.|:....||||..|.:|:||.|.::||.|:
Human   107 IMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGE 171

  Fly   190 RLREIERVTATRINIPSQSDESEFITIAGTKEGIAQAEQEIRQLSAEQYKKSSDRITVPKVYHPF 254
            :|:::|..|||:|.||...|.|..|.|.||||||.:|..|:..:||||.|::.:|:.|.|.:|||
Human   172 KLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPF 236

  Fly   255 IVGPYSENLNKLQEETGARINVPPQQVQKDEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTVSVE 319
            |.|||:..:.::.:|||.|||:||..|.:.|||.:|||:.:|.|.|:::.||::.:||.:|::||
Human   237 IAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVE 301

  Fly   320 VAKPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDSPSETITLRGPQVALGNALTVVYQKSNSVKS 384
            |.|.:|:|||||||:::.|||:.||||||:||:||.|||:.|||....||.|||.||.|:||...
Human   302 VKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTV 366

  Fly   385 VEINAAHWIHKYVIGRKGANMKQLEEDCPNVNVNCL--EDKIKLEGDPENVDRAVAYLSEIIKNY 447
            ..:.|..|:|:::||:||.|:.::.:..|.|::...  ||||.|||..|:|:.|...:..::|:.
Human   367 SSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDL 431

  Fly   448 EENFTFEVMTVNPSYYKHIIGKAGANVNRLKDELKVNINI-EEREGQNNIRIEGPKEGVRQAQLE 511
            .....:..:.::..:::|:|||:|||:||:||:.||::.| .:.|..|.|||||..:||:||:.|
Human   432 INRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRE 496

  Fly   512 LQEKIDKLENEKSKDVIIDRRLHRSIIGAKGEKIREVKDRYRQVTITIPTPQENTDIVKLRGPKE 576
            |.|...::|||::||:||::|.||:|||.|||:|||::|::.:|.|..|.|.:.:|||:|||||.
Human   497 LLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKN 561

  Fly   577 DVDKCHKDLLKLVKEIQESSHIIEVPIFKQFHKFVIGKGGANIKKIRDETQTKIDLPAEGDTNEV 641
            :|:||.|.:.|:|.::.|:|:.|.|||||||||.:||||||||||||:|:.||||||||...:|.
Human   562 EVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSET 626

  Fly   642 IVITGKKENVLEAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLISSIMEECGGVSIKFP 706
            |:||||:.|...|:.||..||.:|::|...||.||.|.:||:|||.|:||.|||||||||.|.||
Human   627 IIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHIHFP 691

  Fly   707 NSDSKSDKVTIRGPKDDVEKAKVQLLELANERQLASFTAEVRAKQQHHKFLIGKNGASIRKIRDA 771
            ...|.||.|.||||..||||||.|||.||.|:|..|||.::|||.::|||||||.|..|||:||:
Human   692 VEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDS 756

  Fly   772 TGARIIFPSNEDTDKEVITIIGKEESVKKAREQLEAIIKECDEVTEGEVSVDPKHHKHFVAKRGF 836
            ||||:|||:.||.|:::|||||||::|::|:::|||:|:..|.|.|..:.||||||:|||.:||.
Human   757 TGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQ 821

  Fly   837 ILHRISEECGGVMISFPRVGINSDKVTIKGAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRHHR 901
            :|..|:||.||||:||||.|..|||||:||||||:|||::||:||:.|||||.|:|..|||:.||
Human   822 VLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHR 886

  Fly   902 TIMGARGFKVQQVTFEFDVQIKFPDRD-----ATEPVEGLTNGGSGENGGE-NEGQEGEQEVEKE 960
            ::||.:|.::||:|.:|.||||||||:     :||||       ..|||.| .||:|.     |:
Human   887 SVMGPKGSRIQQITRDFSVQIKFPDREENAVHSTEPV-------VQENGDEAGEGREA-----KD 939

  Fly   961 AEQEPVRQCDVIRITGRIEKCEAAKQALLDLIPIEEELSVPFDLHRTIIGPRGANVRQFMSKHDV 1025
            .:....|:||:|.|:||.|||||||:||..|:|:..|:.|||||||.:||.:|:.:|:.|.:.:|
Human   940 CDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEV 1004

  Fly  1026 HVELPPSELKSDVIKVCGTPARVAEAREALVKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIG 1090
            ::.:|..||:||:|.:.|..|.:..|:..|::.:::.:|::.||.||||.|.|.||.::|.|:||
Human  1005 NIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIG 1069

  Fly  1091 RHGAVINKLRADHDVIISLPKRD---EPNDRIISITGYQANAEAARDAILEIVGDPETLHREVIE 1152
            |.||||.::|.:|||.|..|.:|   :|.|: |:||||:.|.||||||||.|||:.|.:..|.:.
Human  1070 RKGAVITQIRLEHDVNIQFPDKDDGNQPQDQ-ITITGYEKNTEAARDAILRIVGELEQMVSEDVP 1133

  Fly  1153 IDKRIHPHLIGQRRRTIRKIIEDNKVNIKF-SADDDNPNSIFISGKIEDVENVKELLFGMAEDYE 1216
            :|.|:|..:||.|.:.||||:::.||:|:| .:...:||.:.::|..|:||...:.:..:.|:|.
Human  1134 LDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYL 1198

  Fly  1217 RDYLDNVAI----APPTIGAFLTGQGSGSDAAGASENGFVIKDAPWEKQKQAKNLTAPNTQSQED 1277
            .|.:|:.|:    .||           ..:.|.|...|||::||||......|   ||:..|.|:
Human  1199 ADVVDSEALQVYMKPP-----------AHEEAKAPSRGFVVRDAPWTASSSEK---APDMSSSEE 1249

  Fly  1278 FPHFAAGGAPVASTPITSVWGPK 1300
            ||.|   ||.||  |.|..||||
Human  1250 FPSF---GAQVA--PKTLPWGPK 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dp1NP_001286573.1 vigilin_like_KH 170..231 CDD:239087 29/60 (48%)
vigilin_like_KH 242..>290 CDD:239087 22/47 (47%)
vigilin_like_KH 315..373 CDD:239087 35/57 (61%)
vigilin_like_KH 384..440 CDD:239087 20/57 (35%)
vigilin_like_KH 454..513 CDD:239087 26/59 (44%)
vigilin_like_KH 524..586 CDD:239087 33/61 (54%)
vigilin_like_KH 598..659 CDD:239087 40/60 (67%)
vigilin_like_KH 670..732 CDD:239087 40/61 (66%)
vigilin_like_KH 744..806 CDD:239087 36/61 (59%)
vigilin_like_KH 817..879 CDD:239087 40/61 (66%)
vigilin_like_KH 890..989 CDD:239087 49/104 (47%)
vigilin_like_KH 995..1055 CDD:239087 23/59 (39%)
vigilin_like_KH 1075..1137 CDD:239087 34/64 (53%)
vigilin_like_KH 1149..1208 CDD:239087 21/59 (36%)
HDLBPNP_001307894.1 vigilin_like_KH 152..213 CDD:239087 29/60 (48%)
vigilin_like_KH 224..283 CDD:239087 27/58 (47%)
vigilin_like_KH 297..357 CDD:239087 37/59 (63%)
vigilin_like_KH 368..425 CDD:239087 20/56 (36%)
vigilin_like_KH 438..498 CDD:239087 26/59 (44%)
vigilin_like_KH 509..571 CDD:239087 33/61 (54%)
vigilin_like_KH 583..644 CDD:239087 40/60 (67%)
vigilin_like_KH 655..717 CDD:239087 40/61 (66%)
vigilin_like_KH 729..791 CDD:239087 36/61 (59%)
vigilin_like_KH 802..864 CDD:239087 40/61 (66%)
vigilin_like_KH 875..968 CDD:239087 49/104 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 914..944 12/41 (29%)
vigilin_like_KH 974..1035 CDD:239087 23/60 (38%)
vigilin_like_KH 1055..1118 CDD:239087 34/63 (54%)
vigilin_like_KH 1129..1191 CDD:239087 21/61 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1233..1268 19/43 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154180
Domainoid 1 1.000 94 1.000 Domainoid score I7536
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H38035
Inparanoid 1 1.050 1170 1.000 Inparanoid score I201
Isobase 1 0.950 - 0 Normalized mean entropy S2506
OMA 1 1.010 - - QHG52033
OrthoDB 1 1.010 - - D248989at2759
OrthoFinder 1 1.000 - - FOG0002282
OrthoInspector 1 1.000 - - oto90827
orthoMCL 1 0.900 - - OOG6_104272
Panther 1 1.100 - - LDO PTHR10627
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1639
SonicParanoid 1 1.000 - - X2783
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1514.890

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