DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp1 and RGD1563104

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_001100437.1	Gene:	RGD1563104 / 302773	RGDID:	1563104	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	1212	Identity:	374/1212 - (30%)
Similarity:	640/1212 - (52%)	Gaps:	68/1212 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 SQKTHIVHVPC-KERKSTESEKFGEGESKRICQQITKETGAQIEIVSGKNQSLTFLIKGKQSELL 155
            |..|.:.||.. ||...|:   ||||...:....|.:.||..:|....|:|.|...:.|....:.
  Rat    68 STLTQVFHVLLEKENYLTQ---FGEGTLAKFYAHIMENTGVNLESSFIKDQGLYVTVFGNSEAVT 129

  Fly   156 DARRKILMGFSTQASRQVTVPREHFRVILGKGGQRLREIERVTATRINIPSQSDESEFITIAGTK 220
            :|..:||.....:......:.::.....|.:.|.:.::.|:.......|.|..:.|.:|....|
  Rat   130 NAENEILKWCQEKYLPLTLISKQEHCFFLDQTGDKSQDTEQEAEINAQIISPHNHSHYINTVDT- 193

  Fly   221 EGIAQAEQEIRQLSAEQYKKSSD--RITVPKVYHPFIVGPYSENLNKLQEETGARINVPPQQVQK 283
             .:.:.:.....||.......||  .:.:.|.::|.|..||.:..:..||   ...:||.|....
  Rat   194 -NLTKMKSSDGSLSTSDRNSKSDIQILEMEKAFNPRIGKPYLQASDIFQE---TEEHVPFQLSSA 254

  Fly   284 DEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTVSV-EVAKPKHRYVIGPKGSTIAEILQLTGVSV 347
            :|..:...:..:...:.:...  .||.:|.||::. .:.|.:..|....|.:.:.|||:.:..|.
  Rat   255 NETDVDINERQLNVDQTRCHK--NDMTEKSSTITEGMMMKFQGNYTRSLKRNFLEEILETSEDST 317

  Fly   348 EMPPNDSPSETITLRGPQVALGNALTVVYQKSNSVKSVEINAAHWIHKYVIGRKGANMKQLEEDC 412
            ...|::|.|:::|......:.|.....|:...:......|.|..|:|:::||:||..:.::.|..
  Rat   318 GQSPSESISDSMTQHSEPDSSGEIFNEVHGNDDDYIVSSIFAPSWLHRFIIGKKGEKIAEISECV 382

  Fly   413 PNVNVN-CLEDKIKLEGDPENVDRAVAYLSEIIKNYEENFTFEVMTVNPSYYKHIIGKAGANVNR 476
            |.|.:: ..:|||.|:|..::|:.|......|:|:......:..:..:..::|::.|..||.:|:
  Rat   383 PKVQIHFTAKDKITLKGPIDDVNYAQEKFDIIVKDLISRMEYTEINGDSKFHKYLTGNNGAILNK 447

  Fly   477 LKDELKVNIN-IEEREGQNNIRIEGPKEGVRQAQLELQEKIDKLENEKSKDVIIDRRLHRSIIGA 540
            :.:..:|:|. :.|.|..:.|||||...||:||:.||.:..:.||.|.|:|:||..:.|..:||.
  Rat   448 IAERNQVSITMVPENELNHTIRIEGESLGVQQAKKELLDLANNLEEEYSQDIIIKHQFHHILIGQ 512

  Fly   541 KGEKIREVKDRYRQVTITIPTPQENTDIVKLRGPKEDVDKCHKDLLKLVKEIQESSHIIEVPIFK 605
            |||::||:..::..|.:..|.|.|.:|||:|.||:.:.:||.:.|..::.:|:|:::.|.:.|.|
  Rat   513 KGERVREICKKFPDVILNFPHPAEKSDIVQLIGPRYESEKCAQYLENMLTDIKENNYSISISIIK 577

  Fly   606 QFHKFVIGKGGANIKKIRDETQTKIDLPAEGDTNEVIVITGKKENVLEAKERIQKIQNELSDIVT 670
            :.||.:||||.:|||||.:.|.|||..|.|...:|..:|||..||...|:..|..||.|::|...
  Rat   578 KLHKRLIGKGASNIKKISETTNTKISFPPENCNSEEFIITGYPENCEIARNWILSIQQEIADTAE 642

  Fly   671 EEVQIPPKYYNSIIGTGGKLISSIMEECGGVSIKFPNSDSKSDKVTIRGPKDDVEKAKVQLLELA 735
            ||:.||...|..:......|::||:||||.:.:.||.:.|..:||.|.|..:.|||||.:||:||
  Rat   643 EEITIPTNLYKYLNNPKECLLNSIIEECGKIHLHFPKNKSSLNKVIIMGSVESVEKAKAKLLKLA 707

  Fly   736 NERQLASFTAEVRAKQQHHKFLIGKNGASIRKIRDATGARIIFPSNEDTDKEVITIIGKEESVKK 800
            .|.|..:::.::|.|.|:|:||:.|||.:|.:|.|.||..::||::.:.|:|.:||.|.|||||:
  Rat   708 EEEQAKNYSEKIRVKSQYHQFLVNKNGGNISQICDETGTCVLFPNHTNKDQESLTITGSEESVKE 772

  Fly   801 AREQLEAIIKECDEVTEGEVSVDPKHHKHFVAKRGFILHRISEECGGVMISFPRVGINSDKVTIK 865
            .:::||.::|:.:...:..:.::.:.|.:||.:||.:|..::||.|||:|:|...|..:.|||||
  Rat   773 VQKRLEDLVKDFENEVDDSILINRRFHHYFVMRRGQLLKEMTEEYGGVVITFSYAGRQNTKVTIK 837

  Fly   866 GAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRHHRTIMGARGFKVQQVTFEFDVQIKFPDRDAT 930
            |||.|:|||::.|:.|...|.:|.|...||||.....|||....::||:..::.|:|||||.:
  Rat   838 GAKPCVEAAKKHIKAIFEPLGSQVTTRYVIPQNFQPFIMGPITSRIQQIARDYKVEIKFPDIE-- 900

  Fly   931 EPVEGLTNGGSGENGGENEGQEGEQEVEKEAEQEPVRQCDVIRITGRIEKCEAAKQALLDLIPIE 995
            :|...:      :...:.:|:|..::..|:......|:.|.|.|:|::|.|:||.:||..:||:.
  Rat   901 KPAINM------DLATQEKGKEKWKKPAKDLAPNSPRKSDTIFISGQVENCKAATEALASIIPVT 959

  Fly   996 EELSVPFDLHRTIIGPRGANVRQFMSKHDVHVELPPSELKSDVIKVCGTPARVAEAREALVKMIE 1060
            .|:.||..||..|||.:|:.:|:.:.:.:||::.|.....||:|.:.|..|.|.:|:..|.|.::
  Rat   960 AEVHVPLHLHPYIIGHKGSGLRKLVKEFEVHMQPPQPGKNSDIISIMGLAANVEQAKMKLQKRVK 1024

  Fly  1061 DYEADRADRELRSFVLQVDVDTEFHSKLIGRHGAVINKLRADHDVIISLPKR--DEPNDRIISIT 1123
            ..:.:..||.||:|.|..::|:::.:|:.|..|.:|.::..:|||.:..||:  .|..|: |:||
  Rat  1025 ALQMEIEDRTLRNFKLMFNLDSKYRAKITGHKGLLITQICTEHDVTVRFPKKGSHEVQDQ-ITIT 1088

  Fly  1124 GYQANAEAARDAILEIVGDPETLHREVIEIDKRIHPHLIGQRRRTIRKIIEDNKVNIKFSADDD- 1187
            ||:.|..||||||:.::...|....:.|.:::::..::.|.|.:||.||::..:|:|:......
  Rat  1089 GYKENTLAARDAIMRVLHKIEKTISKEITLNQQVRSNVFGFRGKTINKIMDQYQVDIRSPPKGSY 1153

  Fly  1188 NPNSIFISG-------KIEDVENVKELLFGMAEDYERDY-------LDNVAIAPPTIGAFLTGQG 1238
            ||| |.::|       .||.:.|:::.....|.::|...       |.|:|:.|
  Rat  1154 NPN-ITVTGLPDNVEKAIEHILNLEKYYLSAAANHESQQEEAKSMSLCNIAMTP----------- 1206

  Fly  1239 SGSDAAGASENGFVIKDAPWEKQKQAKNLT-APNTQSQEDFP 1279
                     ...||.|..|.    .||..| .|:..:.|.||
  Rat  1207 ---------SKSFVRKYVPC----YAKTTTKLPDVDNCEHFP 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	8/60 (13%)
		vigilin_like_KH	242..>290	CDD:239087	13/49 (27%)
		vigilin_like_KH	315..373	CDD:239087	13/58 (22%)
		vigilin_like_KH	384..440	CDD:239087	18/56 (32%)
		vigilin_like_KH	454..513	CDD:239087	19/59 (32%)
		vigilin_like_KH	524..586	CDD:239087	24/61 (39%)
		vigilin_like_KH	598..659	CDD:239087	27/60 (45%)
		vigilin_like_KH	670..732	CDD:239087	24/61 (39%)
		vigilin_like_KH	744..806	CDD:239087	26/61 (43%)
		vigilin_like_KH	817..879	CDD:239087	26/61 (43%)
		vigilin_like_KH	890..989	CDD:239087	30/98 (31%)
		vigilin_like_KH	995..1055	CDD:239087	20/59 (34%)
		vigilin_like_KH	1075..1137	CDD:239087	24/63 (38%)
		vigilin_like_KH	1149..1208	CDD:239087	17/66 (26%)
RGD1563104	NP_001100437.1	KH-I	71..136	CDD:412160	19/67 (28%)
		KH-I_Vigilin_rpt5	352..420	CDD:411837	20/67 (30%)
		KH-I_Vigilin_rpt6	422..489	CDD:411804	20/66 (30%)
		KH-I	494..560	CDD:412160	26/65 (40%)
		KH-I_Vigilin_rpt8	570..631	CDD:411839	27/60 (45%)
		KH-I	641..696	CDD:412160	19/54 (35%)
		KH-I	713..778	CDD:412160	26/64 (41%)
		KH-I	789..853	CDD:412160	27/63 (43%)
		KH-I	866..952	CDD:412160	28/93 (30%)
		KH-I	957..1033	CDD:412160	23/75 (31%)
		KH-I	1038..1110	CDD:412160	26/72 (36%)
		KH-I	1112..1177	CDD:412160	17/65 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347791
Domainoid	1	1.000	73	1.000	Domainoid score	I9030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52033
OrthoDB	1	1.010	-	-		D248989at2759
OrthoFinder	1	1.000	-	-		FOG0002282
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104272
Panther	1	1.100	-	-	O	PTHR10627
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2783
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860