DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp1 and vgl1

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_588106.2	Gene:	vgl1 / 2539425	PomBaseID:	SPCC550.14	Length:	1291	Species:	Schizosaccharomyces pombe

Alignment Length:	1280	Identity:	296/1280 - (23%)
Similarity:	564/1280 - (44%)	Gaps:	223/1280 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EETNNATTIEQQPIALINGQE---QVANEQQPSSPTSVATPTSTTSGGTGNATPAFSYDDLFPAL 69
            ::.||:.:..::|...::.::   .:.::..||.|..|:....|.|..:...:.:.|.|.:
pombe    77 KKQNNSKSFSKKPAIDVHSEDAFPTLLSKTGPSKPRIVSWVRKTASNTSVAGSDSVSRDKI---- 137

  Fly    70 PANTSAQSQSGASGSTLARVTSSQKTHIVHVPCKERKSTESEKFGEGES-KRICQQITKETGAQI 133
              ..||.|::.::.|||:.|..:.......:...:.::......|:..| ..|.:.:..:|..:|
pombe   138 --PFSASSRASSTKSTLSSVKETDFVTETLILSPDNQAPRMSFVGKPNSVAEIVRTVMHQTSTRI 200

  Fly   134 EI-VSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGKGGQRLREIERV 197
            .: .:.|.::.||||:||.|.:..|||:||.....:.::.:..|......|:|..||.|:.|...
pombe   201 NVSTASKTKNTTFLIQGKTSAVKAARRQILKLIGRRETKTMPCPVFVVGAIIGTNGQNLKSIMDR 265

  Fly   198 TATRINIPSQSD------------------------------ESEFITIAGTKEGIAQAEQEIRQ 232
            |:|||.||.:::                              |...|||.|..||:..|:::|..
pombe   266 TSTRIQIPKRNNTANESSDDAKKPEKEENSAASTLDDLEPQYEMTTITIEGDFEGVELAQKDIEA 330

  Fly   233 LSAEQYKKSSDRIT-VPKVYHPFIVGPYSENLNKLQEETGARINVP----PQQVQKDEIVISGEK 292
            :..|:...::.||: :....:..:.||..:|:.:|:|....::.:|    ......:.||:||||
pombe   331 IINERTSNTTVRISHISTELYSLLRGPDGKNIKELEEGRDLKVQIPFAYLDPSAPVNPIVLSGEK 395

  Fly   293 DAVAAAKAKVEAIYKDMEKKCSTVSVEVAKPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDSPSE 357
            .||......::...:::.:......:.:.:.:||::.|.||..|.:||:.:|.||.:||.:..|:
pombe   396 SAVRECALYLQGQAEELLRTTIPTMLPIPRRQHRFINGEKGVGIQDILRKSGCSVILPPINGDSD 460

  Fly   358 TITLRGPQVALGNALTVVYQKSNS--VKSVEINAAHWIHK------YVIGR---KGANMKQLEED 411
            .:::|||.:.:...:.:..:::||  |.:|.|..|:...|      .::.|   :...:..|||:
pombe   461 VVSVRGPALNISEGIRLTLERANSTIVDAVNITTAYASSKNPFDIASIVARLFLRSRKLIPLEEE 525

  Fly   412 C-------------PNVNVNCLEDKIKLEG-DPENVDRAVAYLSEIIKNYEENFTFEVMTVNPSY 462
            |             .|.|...:   |::.| ..|.|....|.|..::..:.|:..::| |::|..
pombe   526 CAVQYHLPKREELQSNSNKTVI---IEISGKSQEAVREGRAKLLALVNQFPESKFYKV-TIDPLL 586

  Fly   463 YKHIIGKAGANVNRLKDELKVNINIEEREGQNN----IRIEGPKEGVRQAQLELQEKIDKLENEK 523
            .:::||..|.|:.:|::|.:|.:.:.| .|:.:    :...|..:|....|:: :|..|..|:.|
pombe   587 QRYVIGSKGKNLQKLRNEHQVELLVGE-YGEEDPDVIVCYIGADDGKSPDQIQ-KELADLAESVK 649

  Fly   524 S---------KDVI-IDRRLHRSIIGAKGEKIREV-------------KDRYRQVTITIPTPQEN 565
            |         .::| :....|:.|:|.||..:..:             |..||        |...
pombe   650 SSAEASAKIVSEIIQVPSVYHKHIVGPKGTTLNAIIGKSEENVIVQLGKVSYR--------PDST 706

  Fly   566 TDIVKLRGPKEDVDKCHKDLLKLVKEIQE----SSHIIEVPIFKQFHKFVIGKGGANIKKIRDET 626
            .|.|.:||..:||::...::.::|::.:.    .||:.|.....|:.|.||||.|:|:..:|::.
pombe   707 DDDVYIRGFSKDVERVVSEIKQVVRDAKNHEILHSHVEEFDFPAQYSKNVIGKNGSNVSSLREDL 771

  Fly   627 QTKIDLPAEGDTNEVIVITGKKENVLEAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLI 691
            ..:|:: .||.    |.|.|.|:||.|...||:.....|.|.....|.||..::..:||:.||.:
pombe   772 GVQINV-EEGH----IRIQGIKKNVEETAARIKSQIEALIDDTILRVNIPNDFHRQLIGSNGKYV 831

  Fly   692 SSIMEECGGVSIKFPNSDSKS-------------DKVTIRGPKDDVEKAKVQLLELANERQLASF 743
            .. :||...|.::||..|..|             |:|.|||.|..|..||.:||||....:..::
pombe   832 RR-LEEKFSVRVRFPREDDSSNSTGNELMKPTSPDEVVIRGGKKSVAAAKQELLELYEYEKSIAY 895

  Fly   744 TAEVRAKQQHHKFLIGKNGASIRKIRDATGARIIFPSNEDTDKEVITIIGKEESVKKAREQLEAI 808
            |:.:....:....::|:||:::..||.....:|........:...:::.|.:..|:.|.:::.||
pombe   896 TSTIDIPSKAVSRVVGRNGSTVENIRTQFDVKIDIGDVSTEETTPVSVRGAKADVENAIKEISAI 960

  Fly   809 IKECDEVTEGEVSVDPKHHKHFVAKRGFILHRISEECGGV--------MISFPRVGINSDK--VT 863
            .:|...:.|..:.:|.::|::.:...|..|....:||||.        :|||.......::  |.
pombe   961 AEEVKNLVEKVIKIDREYHRYLIGPNGSKLQNTIKECGGSTDKTETARLISFSNGNSEEERNSVV 1025

  Fly   864 IKGAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRHHRTIMGARGFKVQQVTFEFDVQIKFPDRD 928
            ::|.|:.:||...|:.|||.:|:.|...::.:|||...:|:|..|...:.:..:....:..|  :
pombe  1026 LRGDKEIVEALETRLLEIVEELKNQVEEKIEVPQRCISSIIGRMGSTRRDIERKTSTMLNIP--N 1088

  Fly   929 ATEPVEGLTNGGSGENGGENEGQEGEQEVEKEAEQEPVRQCDVIRITGRIEKCEAAKQALLDLIP 993
            ..:|.|.:|                                  |.|.|..|.||.||:.:.:.:.
pombe  1089 VLDPEETVT----------------------------------ITIVGSPENCEKAKEMIQEKVA 1119

  Fly   994 IE--EELSVPFDLHRTIIGPRGANVRQFMSKHDVHVELP------PSEL---------------- 1034
            .:  :.::||..::.:|:  :|..:::..|...|.|:.|      |:|:
pombe  1120 SQYTQMITVPDTVYESIM--KGILMKKLRSDLKVFVDTPEIKPVQPTEVVLEDHEDGVFPWKLVT 1182

  Fly  1035 ------KSDVIKVCGTPARVAEAREALVKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIGRHG 1093
                  .|....|.|....|.:|..:|.|.|:        :.:.:.:..:.:.|..|.::||..|
pombe  1183 HDYTGSSSSEWAVRGHKENVEKAIASLEKSIK--------QVMENCIAYLGIPTNLHRRIIGSGG 1239

  Fly  1094 AVINKLRADHDVIISLPKRDEPNDRIISITGYQANAEAARDAILE 1138
            ::|||:|....|.|.:|:  .|.|.|:.:.|.:|....|:|.|.|
pombe  1240 SIINKIRKIAQVKIDVPR--TPGDEIVVVQGSRAGVVKAKDLIFE 1282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	21/90 (23%)
		vigilin_like_KH	242..>290	CDD:239087	10/52 (19%)
		vigilin_like_KH	315..373	CDD:239087	17/57 (30%)
		vigilin_like_KH	384..440	CDD:239087	16/78 (21%)
		vigilin_like_KH	454..513	CDD:239087	15/62 (24%)
		vigilin_like_KH	524..586	CDD:239087	17/84 (20%)
		vigilin_like_KH	598..659	CDD:239087	21/60 (35%)
		vigilin_like_KH	670..732	CDD:239087	23/74 (31%)
		vigilin_like_KH	744..806	CDD:239087	10/61 (16%)
		vigilin_like_KH	817..879	CDD:239087	18/71 (25%)
		vigilin_like_KH	890..989	CDD:239087	18/98 (18%)
		vigilin_like_KH	995..1055	CDD:239087	15/89 (17%)
		vigilin_like_KH	1075..1137	CDD:239087	19/61 (31%)
		vigilin_like_KH	1149..1208	CDD:239087
vgl1	NP_588106.2	KH-I	238..329	CDD:238053	21/90 (23%)
		KH-I	345..406	CDD:294072	14/60 (23%)
		vigilin_like_KH	421..473	CDD:239087	17/51 (33%)
		vigilin_like_KH	578..>623	CDD:239087	12/46 (26%)
		vigilin_like_KH	660..727	CDD:239087	16/74 (22%)
		KH	741..802	CDD:197652	24/65 (37%)
		vigilin_like_KH	810..884	CDD:239087	23/74 (31%)
		KH_1	896..957	CDD:278442	10/60 (17%)
		vigilin_like_KH	969..1041	CDD:239087	18/71 (25%)
		KH-I	1052..1115	CDD:238053	18/98 (18%)
		vigilin_like_KH	1223..1280	CDD:239087	19/58 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	44	1.000	Domainoid score	I3598
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I593
OMA	1	1.010	-	-		QHG52033
OrthoFinder	1	1.000	-	-		FOG0002282
OrthoInspector	1	1.000	-	-		oto101698
orthoMCL	1	0.900	-	-		OOG6_104272
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1639
SonicParanoid	1	1.000	-	-		X2783
TreeFam	0	0.000	Not matched by this tool.
	11	11.000