DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp1 and vgln-1

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_496136.1	Gene:	vgln-1 / 174543	WormBaseID:	WBGene00007463	Length:	1220	Species:	Caenorhabditis elegans

Alignment Length:	1303	Identity:	456/1303 - (34%)
Similarity:	726/1303 - (55%)	Gaps:	104/1303 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MEETNNATTIEQQPIALINGQEQVANEQQPSSPTSVATPTSTTSGGTGNATPAFSYDDLFPALPA 71
            :|||||   :|..|                               .||.|..:|||...||.||.
Worm     6 IEETNN---VEIDP-------------------------------ATGGAVMSFSYASDFPTLPD 36

  Fly    72 NTSAQSQSGASGSTLARVT-SSQKTHIVHVPCKERKSTESEKFGE-GESKRICQQITKETGAQIE 134
            ...|.:.:.......:|.| |..:.:|......:.:|.:.:.||. .|..:..|.|...|..:||
Worm    37 AAPASAPTAKQTHVWSRPTLSKSEVNITFRLASDERSNKVKSFGSTSEESKKAQAIATATKTRIE 101

  Fly   135 IVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGKGGQRLREIERVTA 199
            :...|:..||.::||::::..:||.:|:....|||||::.:|::|...::||.|..||.:|..|.
Worm   102 LSESKDGELTVVVKGERAKAEEARARIIRDLQTQASREIDIPKDHHGRLIGKEGALLRNLEAETN 166

  Fly   200 TRINIPSQSDESEFITIAGTKEGIAQAEQEIRQLSAEQYKKSSDRITVPKVYHPFIVGPYSENLN 264
            .||.||::...|..|||.|.:|||.:|...|..:|..:.|.:::.|..||....|:.||.:|..:
Worm   167 CRIQIPNRDGPSSKITITGPREGIQRAAAHILAVSEREAKLATEHIVCPKNLVAFVRGPKNETYD 231

  Fly   265 KLQEETGARINVPPQQVQKDEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTVSVEVAKPKHRYVI 329
            :|.:..|.:||:||..|..:.|.::||||.|....|::..|. :.:|..|::.|.||:.:|||::
Worm   232 RLTQNNGVKINIPPPHVTNEVISVTGEKDGVLRVAAEIRQII-ESKKNVSSIQVAVARTQHRYIV 295

  Fly   330 GPKGSTIAEILQLTGVSVEMPPNDSPSETITLRGPQVALGNALTVVYQKSNSVKSVEINAAHWIH 394
            |...|.|.::||.||..||:|..||.|:.:||.|....|..||.:|.::::||.:..|:|.:|:|
Worm   296 GQSRSGIHDVLQKTGCVVEVPAEDSGSDQVTLIGNAQDLAKALALVIERASSVVTQSISAPNWLH 360

  Fly   395 KYVIGRKGANMKQLEEDCPNVNVNC-LEDKIKLEGDPENVDRAVAYLSEIIKNYEENFTFEVMTV 458
            |::||.|||.:..|..:..||.:.. ..::|.|||.||.|..|...||:.:...:.....|.:.|
Worm   361 KHLIGPKGATLTALVPNRNNVQIEFDNSNQIFLEGSPEEVKLAFEPLSKEVARLQMELAIEKVKV 425

  Fly   459 NPSYYKHIIGKAGANVNRLKDELKVNINI-EEREGQNNIRIEGPKEGVRQAQLELQEKIDKLENE 522
            :|:.::|:||:.|:.::::||:..|.|.| .|....:.|.:||.||||::|..|::..:.|:|||
Worm   426 HPTLHRHVIGRGGSLISKIKDQHGVQITIPNEETNSDEIVVEGKKEGVKKAVTEIRAIVTKIENE 490

  Fly   523 KSKDVIIDRRLHRSIIGAKGEKIREVKDRYRQVTITIPTPQENTDIVKLRGPKEDVDKCHKDLLK 587
            ||:|:||.:|||:.|||:||..::.::|.:..|::..|..:..:|:|.:||.|.:||..:|.|..
Worm   491 KSRDIIIPQRLHKLIIGSKGSGVQVIRDSHPNVSVVFPDAKSKSDVVNIRGDKTEVDAVYKKLTA 555

  Fly   588 LVKEIQESSHIIEVPIFKQFHKFVIGKGGANIKKIRDETQTKIDLPAEGDTNEVIVITGKKENVL 652
            |.||..|:::...|.|||:|.|.::|||||:|:|:||||:|:||||..|..:..|.:|||:.||.
Worm   556 LSKEYAENNYQQTVAIFKEFLKHIVGKGGASIRKLRDETETRIDLPESGSDDGKITVTGKQANVE 620

  Fly   653 EAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLISSIMEECGGVSIKFPNSDSKSDKVTI 717
            :|..::.|||.||:::..|.::||.|..:...|.|.:|||.|.:|||||.|:||:..|:|.||||
Worm   621 KAVAQLNKIQEELANVAEESIEIPQKVQSRFFGNGRRLISDIEDECGGVHIRFPSEKSESTKVTI 685

  Fly   718 RGPKDDVEKAKVQLLELANERQLASFTAEVRAKQQHHKFLIGKNGASIRKIRDATGARIIFPSNE 782
            |||..||.||...|..||.:::.......|:||.:.|:|||||.|:.|.|:||....|::||...
Worm   686 RGPAGDVAKAVGLLSALAKDKEENYVEDTVKAKPEFHRFLIGKGGSKIAKLRDTLNVRVMFPKEG 750

  Fly   783 DTDKEVITIIGKEESVKKAREQLEAIIKECDEVTEGEVSVDPKHHKHFVAKRGFILHRISEECGG 847
            |.:||.|.::||:|.|.||:..||..||:..|..:.:::||||::|:|:|:...::..|.|:.||
Worm   751 DAEKETIHLLGKKEDVPKAKAALEDAIKQLSETVDIKITVDPKYYKNFLARGAALVKEIQEQNGG 815

  Fly   848 VMISFPRVGINSDKVTIKGAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRHHRTIMGARGFKVQ 912
            |:||||:.|.:|.:|:|:|:|.|:|||:.|||::|.|.|.|.|..|.||.:.||.::..||.|:.
Worm   816 VVISFPKNGTDSSEVSIRGSKQCVEAAKNRIEDVVEDYEKQITDNVTIPAQFHRGLLAGRGAKIH 880

  Fly   913 QVTFEFDVQIKFPDRDATEPVEGLTNGGSGENGGENEGQEGEQEVEKEAEQEPVRQCDVIRITGR 977
            ::..:::|.|:||:                   ...||.||.               |.:.::||
Worm   881 ELQSKYNVSIRFPN-------------------NREEGSEGS---------------DQVTVSGR 911

  Fly   978 IEKCEAAKQALLDLIPIEEELSVPFDLHRTIIGPRGANVRQFMSKHDVHVELPPSELKSDVIKVC 1042
            ..|.|.||:|||.::||.:.:.:|.|:||:|||..|..||:.|..:||::.:|......| |.|.
Worm   912 DTKVEEAKEALLAMVPISKVIQLPVDMHRSIIGRGGETVRKLMQDYDVNISIPKDNSSED-ITVT 975

  Fly  1043 GTPARVAEAREALVKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIGRHGAVINKLRADHDVII 1107
            |....|.:|.|||...:.:|||...||:|:.:.:.::|.|::|.|:||:.||.|..|:..:.|||
Worm   976 GQTENVDQALEALRGKLGEYEAQAEDRKLKQWSMSINVPTDYHQKIIGQRGATITALKEKYGVII 1040

  Fly  1108 SLPKRDEPNDRIISITGYQANAEAARDAILEIVGDPETLHREVIEIDKRIHPHLIGQRRRTIRKI 1172
            ::|:.|  .:..|:|.||:..|.....||.|::.:..::..:.|.:|.|.||.|||||.:.::|:
Worm  1041 NVPRED--GNETITIQGYEEKANECAAAIEEMISELRSMFTQEISLDARYHPRLIGQRGKNLKKV 1103

  Fly  1173 IEDNKVNIKF---SADDDNPNSIFISGKIEDVENVKELLFGMAEDYERDYLDNVA----IAPPTI 1230
            :||.:|.|:.   .|:|  ||.:.::||  |..:|.:.:..:..:.|...||||.    ::|
Worm  1104 MEDYRVEIRLPRQGAED--PNLVVVAGK--DENDVYDCIDHLRAEEEEFLLDNVERTQYMSP--- 1161

  Fly  1231 GAFLTGQGSGSDAAGASENGFVIKDAPWEKQKQAKNLTAPNTQSQEDFPHFAAGGAPVASTPITS 1295
                ..|.|.:...........:|.|||:.          :..|.|.||.........|:.....
Worm  1162 ----RQQESNNTRHHQQPTSVQMKGAPWQL----------DLGSSEQFPDMGPAAGSSAAVGGAG 1212

  Fly  1296 VWG 1298
            .||
Worm  1213 AWG 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	24/60 (40%)
		vigilin_like_KH	242..>290	CDD:239087	15/47 (32%)
		vigilin_like_KH	315..373	CDD:239087	24/57 (42%)
		vigilin_like_KH	384..440	CDD:239087	21/56 (38%)
		vigilin_like_KH	454..513	CDD:239087	22/59 (37%)
		vigilin_like_KH	524..586	CDD:239087	23/61 (38%)
		vigilin_like_KH	598..659	CDD:239087	30/60 (50%)
		vigilin_like_KH	670..732	CDD:239087	31/61 (51%)
		vigilin_like_KH	744..806	CDD:239087	27/61 (44%)
		vigilin_like_KH	817..879	CDD:239087	27/61 (44%)
		vigilin_like_KH	890..989	CDD:239087	25/98 (26%)
		vigilin_like_KH	995..1055	CDD:239087	21/59 (36%)
		vigilin_like_KH	1075..1137	CDD:239087	21/61 (34%)
		vigilin_like_KH	1149..1208	CDD:239087	23/61 (38%)
vgln-1	NP_496136.1	vigilin_like_KH	137..198	CDD:239087	24/60 (40%)
		vigilin_like_KH	209..270	CDD:239087	21/60 (35%)
		vigilin_like_KH	281..341	CDD:239087	25/59 (42%)
		vigilin_like_KH	350..407	CDD:239087	21/56 (38%)
		vigilin_like_KH	420..481	CDD:239087	22/60 (37%)
		vigilin_like_KH	492..553	CDD:239087	23/60 (38%)
		vigilin_like_KH	568..626	CDD:239087	30/57 (53%)
		vigilin_like_KH	638..696	CDD:239087	30/57 (53%)
		vigilin_like_KH	712..774	CDD:239087	27/61 (44%)
		vigilin_like_KH	786..847	CDD:239087	27/60 (45%)
		vigilin_like_KH	858..923	CDD:239087	25/98 (26%)
		vigilin_like_KH	929..989	CDD:239087	22/60 (37%)
		vigilin_like_KH	1008..1068	CDD:239087	21/61 (34%)
		vigilin_like_KH	1079..1142	CDD:239087	23/66 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156517
Domainoid	1	1.000	70	1.000	Domainoid score	I6279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38035
Inparanoid	1	1.050	798	1.000	Inparanoid score	I253
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52033
OrthoDB	1	1.010	-	-		D248989at2759
OrthoFinder	1	1.000	-	-		FOG0002282
OrthoInspector	1	1.000	-	-		oto18501
orthoMCL	1	0.900	-	-		OOG6_104272
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1639
SonicParanoid	1	1.000	-	-		X2783
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940