DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp1 and Hdlbp

DIOPT Version :9

Sequence 1:	NP_001286573.1	Gene:	Dp1 / 37116	FlyBaseID:	FBgn0027835	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_001288293.1	Gene:	Hdlbp / 110611	MGIID:	99256	Length:	1268	Species:	Mus musculus

Alignment Length:	1321	Identity:	609/1321 - (46%)
Similarity:	879/1321 - (66%)	Gaps:	75/1321 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAAAVM-----EETNNATTIEQQPIALINGQEQVANEQQPSSPTSVATPTSTTSGGTGNATPAF 60
            |.:.||:     .|..:....:|..:|.:|.:|    |..|        ||
Mouse     1 MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEE----ENDP--------PT-------------- 39

  Fly    61 SYDDLFPALPANT----SAQSQSGASGSTLARVTSSQKTHIVHVPCKERKSTESEKFGEGESKRI 121
             |.|.||.||...    |||..:||..:.:..:.:|..|.:.|||.:|||..:..:|||||..:|
Mouse    40 -YKDAFPPLPEKAACLESAQEPAGAWSNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKI 103

  Fly   122 CQQITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGK 186
            |.:|.:.|||.:|:...|:|.|:.::.||...::.||:.|:....||||..|.:|:||.|.::||
Mouse   104 CLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVPIPKEHHRFVIGK 168

  Fly   187 GGQRLREIERVTATRINIPSQSDESEFITIAGTKEGIAQAEQEIRQLSAEQYKKSSDRITVPKVY 251
            .|::|:::|..|||:|.||...|.|..|.|.||||||.:|..|:..:||||.|::.:|:.|.|.:
Mouse   169 NGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAF 233

  Fly   252 HPFIVGPYSENLNKLQEETGARINVPPQQVQKDEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTV 316
            ||||.|||:..:.::.:|||.|||:||..|.:.|||.:|||:.:|.|.|:::.||::.:||.:|:
Mouse   234 HPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTI 298

  Fly   317 SVEVAKPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDSPSETITLRGPQVALGNALTVVYQKSNS 381
            :|||.|.:|:|||||||:::.|||:.||||||:||:||.|||:.|||....||.|||.||.|:||
Mouse   299 AVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANS 363

  Fly   382 VKSVEINAAHWIHKYVIGRKGANMKQLEEDCPNVNVNCL--EDKIKLEGDPENVDRAVAYLSEII 444
            .....::|..|:|:::||:||.|:.::.:..|.|::...  ||||.|||..|:|:.|...:..::
Mouse   364 FTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMV 428

  Fly   445 KNYEENFTFEVMTVNPSYYKHIIGKAGANVNRLKDELKVNINI-EEREGQNNIRIEGPKEGVRQA 508
            |:......:..:.::..:::|:|||:|||:||:||:.||::.| .:.|..|.|||||..:||:||
Mouse   429 KDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQA 493

  Fly   509 QLELQEKIDKLENEKSKDVIIDRRLHRSIIGAKGEKIREVKDRYRQVTITIPTPQENTDIVKLRG 573
            :.||.|...::|||::||:||::|.||:|||.|||:|||::|::.:|.|..|.|.:.:|||:|||
Mouse   494 KRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRG 558

  Fly   574 PKEDVDKCHKDLLKLVKEIQESSHIIEVPIFKQFHKFVIGKGGANIKKIRDETQTKIDLPAEGDT 638
            ||.:|:||.|.:.|:|.::.|:|:.|.|||||||||.:||||||||||||:|:.||||||||...
Mouse   559 PKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSN 623

  Fly   639 NEVIVITGKKENVLEAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLISSIMEECGGVSI 703
            :|.|:||||:.|...|:.||..||.:|::|...||.||.|.:||:|||.|:||.|||||||||.|
Mouse   624 SETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHI 688

  Fly   704 KFPNSDSKSDKVTIRGPKDDVEKAKVQLLELANERQLASFTAEVRAKQQHHKFLIGKNGASIRKI 768
            .||...|.||.|.||||..||||||.|||.||.|:|..|||.::|||.::|||||||.|..|||:
Mouse   689 HFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKV 753

  Fly   769 RDATGARIIFPSNEDTDKEVITIIGKEESVKKAREQLEAIIKECDEVTEGEVSVDPKHHKHFVAK 833
            ||:||||||||:.||.|:::|||||||::|::|:::|||:|:..:.|.|..:.||||||:|||.:
Mouse   754 RDSTGARIIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLENVVEDYMLVDPKHHRHFVIR 818

  Fly   834 RGFILHRISEECGGVMISFPRVGINSDKVTIKGAKDCIEAARQRIEEIVADLEAQTTIEVVIPQR 898
            ||.:|..|:||.||||:||||.|..|||||:||||||:|||::||:||:.|||||.|:|..|||:
Mouse   819 RGQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTVECAIPQK 883

  Fly   899 HHRTIMGARGFKVQQVTFEFDVQIKFPDRDATEPVEGLTNGGSGENGGE-NEGQEGEQEVEKEAE 962
            .||::||.:|.::||:|.:::||||||||: ..||..: .....|||.| .||:|.     ||.:
Mouse   884 FHRSVMGPKGSRIQQITRDYNVQIKFPDRE-ENPVHSV-EPSIQENGDEAGEGREA-----KETD 941

  Fly   963 QEPVRQCDVIRITGRIEKCEAAKQALLDLIPIEEELSVPFDLHRTIIGPRGANVRQFMSKHDVHV 1027
            ....|:||:|.|:||.|||||||:||..|:|:..|:.|||||||.|||.:|:.:|:.|.:.:|::
Mouse   942 PGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYIIGQKGSGIRKMMDEFEVNI 1006

  Fly  1028 ELPPSELKSDVIKVCGTPARVAEAREALVKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIGRH 1092
            .:|..||:||.|.:.|..|.:..|:..|:..:::.:|::.||.||||.|.|.||.::|.|:|||.
Mouse  1007 HVPAPELQSDTIAITGLAANLDRAKAGLLDRVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRK 1071

  Fly  1093 GAVINKLRADHDVIISLPKRD---EPNDRIISITGYQANAEAARDAILEIVGDPETLHREVIEID 1154
            ||||.::|.:|:|.|..|.:|   :|.|: |:||||:.|.||||||||:|||:.|.:..|.:.:|
Mouse  1072 GAVITQIRLEHEVNIQFPDKDDGNQPQDQ-ITITGYEKNTEAARDAILKIVGELEQMVSEDVPLD 1135

  Fly  1155 KRIHPHLIGQRRRTIRKIIEDNKVNIKF-SADDDNPNSIFISGKIEDVENVKELLFGMAEDYERD 1218
            .|:|..:||.|.:.||||:::.||:|:| .:...:||.:.::|..|:||...:.:..:.|:|..|
Mouse  1136 HRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLAD 1200

  Fly  1219 YLDNVAI----APPTIGAFLTGQGSGSDAAGASENGFVIKDAPWEKQKQAKNLTAPNTQSQEDFP 1279
            .:|:.|:    .||           ..:.:.|...|||::||||......|   ||:..|.|:||
Mouse  1201 VVDSEALQVYMKPP-----------AHEESRAPSKGFVVRDAPWTSNSSEK---APDMSSSEEFP 1251

  Fly  1280 HFAAGGAPVASTPITSVWGPK 1300
            .|   ||.||  |.|..||||
Mouse  1252 SF---GAQVA--PKTLPWGPK 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp1	NP_001286573.1	vigilin_like_KH	170..231	CDD:239087	29/60 (48%)
		vigilin_like_KH	242..>290	CDD:239087	22/47 (47%)
		vigilin_like_KH	315..373	CDD:239087	35/57 (61%)
		vigilin_like_KH	384..440	CDD:239087	20/57 (35%)
		vigilin_like_KH	454..513	CDD:239087	26/59 (44%)
		vigilin_like_KH	524..586	CDD:239087	33/61 (54%)
		vigilin_like_KH	598..659	CDD:239087	40/60 (67%)
		vigilin_like_KH	670..732	CDD:239087	40/61 (66%)
		vigilin_like_KH	744..806	CDD:239087	37/61 (61%)
		vigilin_like_KH	817..879	CDD:239087	40/61 (66%)
		vigilin_like_KH	890..989	CDD:239087	47/99 (47%)
		vigilin_like_KH	995..1055	CDD:239087	24/59 (41%)
		vigilin_like_KH	1075..1137	CDD:239087	33/64 (52%)
		vigilin_like_KH	1149..1208	CDD:239087	21/59 (36%)
Hdlbp	NP_001288293.1	KH-I	77..144	CDD:412160	26/66 (39%)
		KH-I	147..221	CDD:412160	36/73 (49%)
		KH-I	224..283	CDD:412160	27/58 (47%)
		KH-I	297..358	CDD:412160	37/60 (62%)
		KH-I	364..433	CDD:412160	21/68 (31%)
		KH-I	435..502	CDD:412160	28/66 (42%)
		KH-I	507..573	CDD:412160	34/65 (52%)
		KH-I	583..644	CDD:412160	40/60 (67%)
		KH-I	653..722	CDD:412160	45/68 (66%)
		KH-I	726..791	CDD:412160	39/64 (61%)
		KH-I	802..867	CDD:412160	42/64 (66%)
		KH-I	875..970	CDD:412160	48/101 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..947		14/43 (33%)
		KH-I	972..1049	CDD:412160	28/76 (37%)
		KH-I	1053..1126	CDD:412160	39/73 (53%)
		KH-I	1128..1196	CDD:412160	21/67 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1213..1268		28/74 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844418
Domainoid	1	1.000	94	1.000	Domainoid score	I7521
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38035
Inparanoid	1	1.050	1157	1.000	Inparanoid score	I206
Isobase	1	0.950	-	0	Normalized mean entropy	S2506
OMA	1	1.010	-	-		QHG52033
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002282
OrthoInspector	1	1.000	-	-		oto94410
orthoMCL	1	0.900	-	-		OOG6_104272
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1639
SonicParanoid	1	1.000	-	-		X2783
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.880