DRSC/TRiP Functional Genomics Resources

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Protein Alignment GstE8 and CLIC1

DIOPT Version :10

Sequence 1:NP_611330.2 Gene:GstE8 / 37113 FlyBaseID:FBgn0063492 Length:222 Species:Drosophila melanogaster
Sequence 2:NP_001279.2 Gene:CLIC1 / 1192 HGNCID:2062 Length:241 Species:Homo sapiens


Alignment Length:183 Identity:41/183 - (22%)
Similarity:65/183 - (35%) Gaps:52/183 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 ILYGTEASPPVRAAKLTLAALGIPYEYVKINTLAKETLSPEFLRKNPQHTVPTLEDDGHFIWDSH 69
            :|||||........:..|.|:..|..|.|:..|            ||:.....|:....|     
Human    67 LLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAAL------------NPESNTAGLDIFAKF----- 114

  Fly    70 AISAYLVSKYGQSDTLYPKDLLQR-AVVDQRLHFESGVVFVNGLRGITKPLFATGQTTIPKERYD 133
              |||:.:.....:....|.||:. .|:|..|               |.||        |:|..:
Human   115 --SAYIKNSNPALNDNLEKGLLKALKVLDNYL---------------TSPL--------PEEVDE 154

  Fly   134 AVIEIYDFVETFLTGHDFIAGDQLTIADFSLITSITALAVFVVIDTVKYANIT 186
            ...|     :..::...|:.|::||:||.:|:..:.    .|.:...||...|
Human   155 TSAE-----DEGVSQRKFLDGNELTLADCNLLPKLH----IVQVVCKKYRGFT 198

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GstE8NP_611330.2 GstA 4..209 CDD:440390 41/183 (22%)
CLIC1NP_001279.2 Required for insertion into the membrane 2..90 7/22 (32%)
O-ClC 6..241 CDD:129941 41/183 (22%)
G-site. /evidence=ECO:0000305|PubMed:25581026 24..27
Blue background indicates that the domain is not in the aligned region.

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