Protein Alignment GstE7 and CLIC2

DIOPT Version :10

• Sequence 1: NP_611329.1
• Gene: GstE7 / 37112
• FlyBaseID: FBgn0063493
• Length: 223
• Species: Drosophila melanogaster
• Sequence 2: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Alignment Length: 191
• Identity: 41/191 - (21%)
• Similarity: 74/191 - (38%)
• Gaps: 55/191 - (28%)

  Fly    15 VRAVKLTLAALEV---PYE-----------FVEVNTRAKENF--SEEFLKKN---PQ--HTVPTL 58
            ::.||..:..:::   |.|           |:..|...|.:|  .||||::.   |:  |..|..
Human    42 LKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKY 106

  Fly    59 EDDGHYIWDSHAIIAYLVSKYGKTDSLYPKDLLQRAVVDQRLHFESGVI--FANALRSITKPLFA 121
            :       :|..:...|.:|:    |.|.|:..:.|    ..:||..::  |......:..||.
Human   107 K-------ESFDVGCNLFAKF----SAYIKNTQKEA----NKNFEKSLLKEFKRLDDYLNTPLL- 155

  Fly   122 GKQTMIPKERYDAIIEVYDFLEKFLAGNDYVAGNQLTIADFSIISTVSSLEVFVKVDTTKY 182
              ..:.|....:..:....||:          |:|||:||.|::..::    .:||...||
Human   156 --DEIDPDSAEEPPVSRRLFLD----------GDQLTLADCSLLPKLN----IIKVAAKKY 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstE7	NP_611329.1	GST_N_Delta_Epsilon	4..77	CDD:239343	17/82 (21%)
		GST_C_Delta_Epsilon	91..209	CDD:198287	20/94 (21%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		12/53 (23%)
		N-terminal	1..94		12/51 (24%)
		O-ClC	12..245	CDD:129941	41/191 (21%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33
		Joint loop	95..106		3/10 (30%)
		C-terminal	107..247		26/126 (21%)
		Foot loop	151..171		3/22 (14%)