DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstE4 and MARS1

DIOPT Version :9

Sequence 1:	NP_611326.1	Gene:	GstE4 / 37109	FlyBaseID:	FBgn0063496	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens

Alignment Length:	163	Identity:	36/163 - (22%)
Similarity:	59/163 - (36%)	Gaps:	59/163 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 VPLLQ-DDDACIWDSHAIMAY--LVEKYAPSDELYPKDLLQRAKVDQLMHFESGVIFESALRRLT 116
            ||:|| |....::.:.||..|  |:..:...|           ..:|.:.:|:     :.|:...
Human    48 VPVLQLDSGNYLFSTSAICRYFFLLSGWEQDD-----------LTNQWLEWEA-----TELQPAL 96

  Fly   117 RPVLFF-------GEPTL--PRNQVDHILQVYDFVETFLDDHD-------FVAGDQLTIADFSIV 165
            ...|::       ||..|  .|..:.||            ||.       |:||:..::||
Human    97 SAALYYLVVQGKKGEDVLGSVRRALTHI------------DHSLSRQNCPFLAGETESLAD---- 145

  Fly   166 STITSIGVFLEL--DPAKYPK----IAAWLERL 192
              |...|....|  |||..|:    :.:|.:.|
Human   146 --IVLWGALYPLLQDPAYLPEELSALHSWFQTL 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstE4	NP_611326.1	GST_N_Delta_Epsilon	4..77	CDD:239343	9/24 (38%)
		GstA	6..196	CDD:223698	36/163 (22%)
		GST_C_Delta_Epsilon	91..209	CDD:198287	26/124 (21%)
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	7/19 (37%)
		GstA	<47..189	CDD:223698	36/163 (22%)
		GST_C_MetRS_N	77..179	CDD:198340	27/134 (20%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900