DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstE3 and CLIC2

DIOPT Version :9

Sequence 1:	NP_611325.2	Gene:	GstE3 / 37108	FlyBaseID:	FBgn0063497	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_001280.3	Gene:	CLIC2 / 1193	HGNCID:	2063	Length:	247	Species:	Homo sapiens

Alignment Length:	173	Identity:	40/173 - (23%)
Similarity:	69/173 - (39%)	Gaps:	44/173 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SPPVRSVLLTLRALNLDFDYKIVNLMEKEHLKPEFLKINPLHTVPALDDNGFYLADSHAINSYLV 76
            :||   .|:..:.|..|| .||...:|:....|.:..::|.:            .:|..:...|.
Human    69 NPP---FLVYNKELKTDF-IKIEEFLEQTLAPPRYPHLSPKY------------KESFDVGCNLF 117

  Fly    77 SKYGRNDSLYPKDLKKRAIVDQRLHYDSSVVTSTGRA---ITFPLFWENKTEIPQARIDALEGVY 138
            :|:    |.|.|:.:|.|    ..:::.|::....|.   :..||       :.:...|:.|...
Human   118 AKF----SAYIKNTQKEA----NKNFEKSLLKEFKRLDDYLNTPL-------LDEIDPDSAEEPP 167

  Fly   139 KSLNLFLENGNYLAGDNLTIADFHVIAGLTGFFVFLPVDATKY 181
            .|..|||:      ||.||:||..::..|.    .:.|.|.||
Human   168 VSRRLFLD------GDQLTLADCSLLPKLN----IIKVAAKKY 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstE3	NP_611325.2	GstA	4..195	CDD:223698	40/173 (23%)
		GST_N_Delta_Epsilon	4..77	CDD:239343	13/64 (20%)
		GST_C_Delta_Epsilon	91..208	CDD:198287	23/94 (24%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		9/30 (30%)
		N-terminal	1..94		9/28 (32%)
		O-ClC	12..245	CDD:129941	40/173 (23%)
		Joint loop	95..106		2/10 (20%)
		C-terminal	107..247		29/119 (24%)
		Foot loop	151..171		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840