Protein Alignment GstE10 and CLIC2

DIOPT Version :10

• Sequence 1: NP_611322.1
• Gene: GstE10 / 37105
• FlyBaseID: FBgn0063499
• Length: 240
• Species: Drosophila melanogaster
• Sequence 2: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Alignment Length: 234
• Identity: 48/234 - (20%)
• Similarity: 86/234 - (36%)
• Gaps: 81/234 - (34%)

  Fly    18 VLLTLRALQLDHEFHTLDMQAGDHLKPDMLRKNPQHTVPMLEDGESCIWDSHAIIGYLV-NKYAQ 81
            ::|.|:.::.:  ..|:||..    ||:.|:.....|.|                .:|| ||..:
Human    38 MILWLKGVKFN--VTTVDMTR----KPEELKDLAPGTNP----------------PFLVYNKELK 80

  Fly    82 SDELYPKDPLKRAVVDQRL---------HFETGVLFHGIFKQLQRALFKENATEVPKDRLAELK- 136
            :|.:..::.|::.:...|.         .|:.|......|....:...||......|..|.|.|
Human    81 TDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKR 145

  Fly   137 -DAY---ALLEQF---LAENP------YVAGPQLTIADFSIVATVSTLHLSYCPVDATKYPKLSA 188
             |.|   .||::.   .||.|      ::.|.|||:||.|::                  |||:
Human   146 LDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLL------------------PKLN- 191

  Fly   189 WLARISALPFYEEDNLRGARLLADKIRSKLPKQFDKLWQ 227
             :.:::|..:.:.|               :|.:|..:|:
Human   192 -IIKVAAKKYRDFD---------------IPAEFSGVWR 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstE10	NP_611322.1	GST_N_Delta_Epsilon	4..77	CDD:239343	12/59 (20%)
		GST_C_Delta_Epsilon	91..211	CDD:198287	30/142 (21%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		16/79 (20%)
		N-terminal	1..94		16/77 (21%)
		O-ClC	12..245	CDD:129941	48/234 (21%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33
		Joint loop	95..106		1/10 (10%)
		C-terminal	107..247		31/143 (22%)
		Foot loop	151..171		5/19 (26%)