DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fj and FJX1

DIOPT Version :9

Sequence 1:	NP_477483.1	Gene:	fj / 37089	FlyBaseID:	FBgn0000658	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_055159.2	Gene:	FJX1 / 24147	HGNCID:	17166	Length:	437	Species:	Homo sapiens

Alignment Length:	500	Identity:	156/500 - (31%)
Similarity:	222/500 - (44%)	Gaps:	96/500 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 MALGVVVPMFG--LPRHQDSPPDLPEEQIQMVAVEPLSSYRVEFIKETDELSAEQVFRNAFHLEQ 152
            :|||.::.::|  ||...:.|...|.|                          :::.|.......
Human    17 LALGSLLALWGGLLPPRTELPASRPPE--------------------------DRLPRRPARSGG 55

  Fly   153 DKDAPDSMVVKKL--DTNDGSIKEFHVQRT-ASGRYRKGPERRLSKKMPERVQPQETSRSPTTSP 214
            ...||...:...|  |...||:|.|....| |:|  ..||.|:      .|.:|:.     ..|.
Human    56 PAPAPRFPLPPPLAWDARGGSLKTFRALLTLAAG--ADGPPRQ------SRSEPRW-----HVSA 107

  Fly   215 TNPTSEHQAGFIEEDVYWGPTVEQALPKGFAAKDQVSWERFVGEQGRVVRLEQ-GCGRMQNRMVV 278
            ..|..|..|. :...|:|...:|:.:|.||:.....:|.. .....|:|.||: ||||..||:..
Human   108 RQPRPEESAA-VHGGVFWSRGLEEQVPPGFSEAQAAAWLE-AARGARMVALERGGCGRSSNRLAR 170

  Fly   279 FADGTRACARYRQNTDQIQGEIFSYYLGQLLNIS-NLAPSAATVVDTSTPNWAAALGDITQAQWK 342
            ||||||||.||..|.:|||||..||||.:||.:. ::.|.|...|:.....||....::..|.|.
Human   171 FADGTRACVRYGINPEQIQGEALSYYLARLLGLQRHVPPLALARVEARGAQWAQVQEELRAAHWT 235

  Fly   343 ERRPVVLTRWLSDLEPAGIPQPFQPLERHLNKHDVWNLTRHMQSERQAQSQPHGLLKRLGAASSP 407
            |...|.|||||.:|....:|.|             |      :||       .|.|:.|..|
Human   236 EGSVVSLTRWLPNLTDVVVPAP-------------W------RSE-------DGRLRPLRDA--- 271

  Fly   408 GSAHQSNAIEETGTGTETANGALVQRLIELAQWSDLIVFDYLIANLDRVVNNLYNFQWNADIMAA 472
                          |.|.||.:..: |::|.||:|||:||||.||.||:|:||::.||:..:|..
Human   272 --------------GGELANLSQAE-LVDLVQWTDLILFDYLTANFDRLVSNLFSLQWDPRVMQR 321

  Fly   473 PAHNLARQSASQLLVFLDNESGLLHGYRLLKKYEAYHSLLLDNLCVFRRPTIDALRRL-RAAGAG 536
            ...||.| .....|||||||:||:||||:...::.|:..||.::||||..|...:..| |...|.
Human   322 ATSNLHR-GPGGALVFLDNEAGLVHGYRVAGMWDKYNEPLLQSVCVFRERTARRVLELHRGQDAA 385

  Fly   537 RRLRDLFERTTSAGVRDVLPSLPDKSVKILVERIDRVLGQVQKCQ 581
            .||..|:.|.......  |.:|.|...::|..|:|.:...:..|:
Human   386 ARLLRLYRRHEPRFPE--LAALADPHAQLLQRRLDFLAKHILHCK 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fj	NP_477483.1	Four-jointed-like_C	255..583	CDD:198459	119/329 (36%)
FJX1	NP_055159.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..66		6/58 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..116		9/40 (23%)
		Four-jointed-like_C	149..430	CDD:198459	119/326 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155485
Domainoid	1	1.000	187	1.000	Domainoid score	I3335
eggNOG	1	0.900	-	-		E1_28N0C
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7717
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3932
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1414662at2759
OrthoFinder	1	1.000	-	-		FOG0007373
OrthoInspector	1	1.000	-	-		oto91294
orthoMCL	1	0.900	-	-		OOG6_110463
Panther	1	1.100	-	-	LDO	PTHR13147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4574
SonicParanoid	1	1.000	-	-		X5496
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790