DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and Gyc76C

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	191/553 - (34%)
Similarity:	274/553 - (49%)	Gaps:	127/553 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 RGLLHHLSEQIKETDNSGVWRYLVGFKNLLKSIECQNIATSFGIR-----------YYGRGSL-- 309
            ||.:..:.| :|......:.|.::....||:.:...||.:..|..           |..:|||
  Fly   574 RGAVVRIKE-LKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYD 637

  Fly   310 TAEN--------FVSYVRYEFMAREMI---NSTLNYAPMLKNMYTNITSTKKF---------HRA 354
            ..||        |::.:.:: :.:.||   ||.|.|...||:  :|...|.::         |..
  Fly   638 IIENEDIKLDDLFIASLIHD-LIKGMIYIHNSQLVYHGNLKS--SNCVVTSRWMLQVTDFGLHEL 699

  Fly   355 KQMGTT------------------LLKNNPNVSNERS----AIEYYELMN--------NYTDDLR 389
            :|....                  ||:|:.:.|.:..    ||..||:.:        |:..
  Fly   700 RQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEP--- 761

  Fly   390 ILQKALRRLIKEYVDK--------------TLVEADRKEAIGIAILVVVLIVSP-------VIIV 433
                   :.|.:||.|              :::||:......:|.:.......|       ||..
  Fly   762 -------KEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRN 819

  Fly   434 LVKNAAA------------TIQLYALNL----SQKAKELKREKRKSDSLLFQMLPPSVAMQLKQT 482
            .:|....            .::.||.||    :::.:.|..||.|::.||.:|||.|||.:|...
  Fly   820 RLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMG 884

  Fly   483 QQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMV 547
            |.|....|:.||||||||||||.::|:.|||:||.|||.:|.|||..|..|||||||||||:|||
  Fly   885 QGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMV 949

  Fly   548 ASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCL 612
            .||||:|||::|..|||:|||:||.|....||....:|.:::|.|:||||||||:||..||||||
  Fly   950 VSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCL 1014

  Fly   613 FGDTVNTASRMESTGEAQKIHITEEMHDSLQQV-GGFRTEHRGLIDVKGKGLMSTYWLTCKDGPV 676
            |||||||||||||.|||.||||:.:...:|.:: ||:.||.|||:::||||.:.|:|||
  Fly  1015 FGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLT------ 1073

  Fly   677 RAREEISWRADIQPVFLDHLKLHPPTDYKLPKR 709
            .|.|..     ||...:|.:.:.||. :..|::
  Fly  1074 GANENA-----IQKKLVDMMDMPPPL-FSRPRK 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	38/200 (19%)
		HNOBA	<439..479	CDD:285003	16/55 (29%)
		CYCc	459..647	CDD:214485	114/188 (61%)
		Guanylate_cyc	485..669	CDD:278633	113/184 (61%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	49/266 (18%)
		HNOBA	<835..881	CDD:285003	16/45 (36%)
		CYCc	860..1052	CDD:214485	116/191 (61%)
		Guanylate_cyc	887..1074	CDD:278633	116/192 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910