DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and CYR1

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	662	Identity:	129/662 - (19%)
Similarity:	224/662 - (33%)	Gaps:	207/662 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 IFTNGSKQ--------------RANLTLRFAN----------------TDHALNNMTTWSEISV- 206
            :|..|:.|              |.|..|::.|                .|..|:::|...::.|
Yeast  1261 VFDVGANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVLPQLKVL 1325

  Fly   207 ---------PTAPDEDEDDR----EMMLN--RYEFQSRLNEFRDRV--------RLEPEESSITE 248
                     ...|||:.:.|    ..::|  ||.....|.: ||.|        |....:.....
Yeast  1326 GLMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQ-RDYVSSRDVTFERFRGNDDECLL 1389

  Fly   249 VMNWYTSINRGLLHHLSEQIKETDNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAEN 313
            .::...:.|....|::|..:::          :..|.|::.:|          ||   |..|.:|
Yeast  1390 CLHDSKNQNADYGHNISRIVRD----------IYDKILIRQLE----------RY---GDETDDN 1431

  Fly   314 FVSYVRYEFM-----AREMINSTLNYAPMLKNMYTNI----TSTKKFHRAKQMGTT--------L 361
            ..:.:|:.|:     ...|:||..|.|.:....|.::    .||..:.|.|::...        |
Yeast  1432 IKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAIL 1496

  Fly   362 LKNNPNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKEYVDKTLVE--ADRKEAIGIAILVVV 424
            .|||.         :|..|...:....|...:.: |:...||:...::  .|...|:|...|:..
Yeast  1497 SKNNG---------DYQTLTKQHLPTKREEYERI-RISGGYVNNGKLDGVVDVSRAVGFFDLLPH 1551

  Fly   425 LIVSPVIIVLVKNAA------ATIQLYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQLKQ-- 481
            :..||.|.|:....|      ||.:|:.........::.||....        |...|.:||.
Yeast  1552 IHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTD--------PLRAAAELKDHA 1608

  Fly   482 -----TQQVP---AELYEAV---------------------------------------TIYFSD 499
                 |:.:.   ..|||.:                                       .:.|:|
Yeast  1609 MAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLAMVFTD 1673

  Fly   500 IVGFT---EIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHIS 561
            |...|   |:..:.....:.|. |.|.|   .::..|..|:|:|.||::|||...|...    ::
Yeast  1674 IKSSTFLWELFPNAMRTAIKTH-NDIMR---RQLRIYGGYEVKTEGDAFMVAFPTPTSG----LT 1730

  Fly   562 EIATMALDLLDASSVFRIPRAGD-------------EFVQIRCGVHTG-PVVAGIVGTKMPRYCL 612
            ...::.|.||||.....|....|             :.:.:|.|:|.| ||....:.|:...|
Yeast  1731 WCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRMDY-- 1793

  Fly   613 FGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLTCKDGPVR 677
            .|..||.|:|::...:..:|.::.:.:....::..:   |..:  ||||..:...:.....|.|.
Yeast  1794 LGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKY---HERV--VKGKESLKEVYGEEIIGEVL 1853

  Fly   678 AR-----EEISW 684
            .|     |.|.|
Yeast  1854 EREIAMLESIGW 1865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	53/293 (18%)
		HNOBA	<439..479	CDD:285003	8/45 (18%)
		CYCc	459..647	CDD:214485	49/253 (19%)
		Guanylate_cyc	485..669	CDD:278633	48/242 (20%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	3/11 (27%)
		leucine-rich repeat	796..817	CDD:275380
		leucine-rich repeat	818..839	CDD:275380
		leucine-rich repeat	840..864	CDD:275380
		leucine-rich repeat	865..887	CDD:275380
		leucine-rich repeat	888..910	CDD:275380
		leucine-rich repeat	911..933	CDD:275380
		leucine-rich repeat	934..956	CDD:275380
		leucine-rich repeat	957..978	CDD:275380
		leucine-rich repeat	979..1018	CDD:275380
		leucine-rich repeat	1019..1041	CDD:275380
		leucine-rich repeat	1042..1065	CDD:275380
		leucine-rich repeat	1066..1088	CDD:275380
		leucine-rich repeat	1089..1111	CDD:275380
		leucine-rich repeat	1167..1187	CDD:275380
		leucine-rich repeat	1191..1211	CDD:275380
		leucine-rich repeat	1236..1258	CDD:275380
		leucine-rich repeat	1259..1287	CDD:275380	5/25 (20%)
		PP2C	1374..1617	CDD:395385	53/283 (19%)
		CYCc	1613..1825	CDD:214485	44/221 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900