Protein Alignment CG33958 and Gucy2d

DIOPT Version :10

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_077356.1
• Gene: Gucy2d / 79222
• RGDID: 620438
• Length: 1108
• Species: Rattus norvegicus
• Alignment Length: 801
• Identity: 230/801 - (28%)
• Similarity: 335/801 - (41%)
• Gaps: 249/801 - (31%)

  Fly    51 DVNPSGEGGLLLVPTHHNLQLDKI--SVRSISS---------------------EDISNGGSGRC 92
            |.:.:||   .|..||   .||.:  |:||..:                     :.|.|||
  Rat   409 DTDAAGE---RLFTTH---LLDPVLGSLRSAGTPVHFPRGAPAPGPDPSCWFDPDVICNGG---- 463

  Fly    93 CNAAARNPAIKTGRRLQLMQMIILPFIPILALIV--QTSVTLQEILEYRSAVADIETQVTIATDL 155
                     ::.|          |.|:..|.:||  .|...|...|.:|.      ..:.:.:..
  Rat   464 ---------VEPG----------LVFVGFLLVIVVGLTGAFLAHYLRHRL------LHMQMVSGP 503

  Fly   156 GKVVTRLQLERSEVAFYIFTNGSKQ------RANLTLRFANTDHALNNMTTWSEI-SVPTAPDED 213
            .|::..|:    :|.|.....||.:      |::|..|            :.|:| |||:.|.|.
  Rat   504 NKIILTLE----DVTFLHPQGGSSRKVAQGSRSSLATR------------STSDIRSVPSQPQES 552

  Fly   214 EDDREMMLNRYEFQ-----------------------SRLNEFR-DRVRL--------------E 240
            .:     :..||..                       |:|.|.| :.|.|              .
  Rat   553 TN-----IGLYEGDWVWLKKFPGEHHMAIRPATKMAFSKLRELRHENVALYLGLFLAGTADSPAT 612

  Fly   241 PEESSITEVMNWYTSINRGLLHHLSEQIKETDNSGVWRY--------LVGFKNL---------LK 288
            |.| .|..|::.:.:  ||.||.|   :.:.|....|.:        :.|.:.|         ||
  Rat   613 PGE-GILAVVSEHCA--RGSLHDL---LAQRDIKLDWMFKSSLLLDLIKGMRYLHHRGVAHGRLK 671

  Fly   289 SIECQNIATSFGIRY----YG---------------------------------RGSLTAENF-V 315
            |..|. :...|.::.    :|                                 ||:|..:.| :
  Rat   672 SRNCV-VDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPELLRDPALERRGTLAGDVFSL 735

  Fly   316 SYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYEL 380
            ..:..|.:.|....:.|...|  :.:...:.|.....|            |.||.:::.:|..:|
  Rat   736 GIIMQEVVCRSTPYAMLELTP--EEVIQRVRSPPPLCR------------PLVSMDQAPMECIQL 786

  Fly   381 MNNYTDDLRILQKALRRLIKEYVDKTL-----VEADRKEAIGIAILVVVLIVSPVIIVLVKNAAA 440
            |.....:...|:.::        |.|.     :...||..|                  :.:...
  Rat   787 MAQCWAEHPELRPSM--------DLTFDLFKGINKGRKTNI------------------IDSMLR 825

  Fly   441 TIQLYALNLS----QKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIV 501
            .::.|:.||.    ::.:||::||:|:|.||.||||||||..||....|..|.:|.||:||||||
  Rat   826 MLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIV 890

  Fly   502 GFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATM 566
            |||.|:|...|:|||..||.:|.:||..|..:||||||||||:||||||||.:||.:|.:|||.|
  Rat   891 GFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANM 955

  Fly   567 ALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQK 631
            :||:|.|...||:....:..|:||.|:|:||.|||:||..|||||||||||||||||||||...:
  Rat   956 SLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYR 1020

  Fly   632 IHI---TEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLTCKDGPVRAREEISWRADIQPVFL 693
            ||:   |..:..:|.|  ||:.|.||..::||||:..||||.   |.|...:.|....|:||...
  Rat  1021 IHVNMSTVRILRALDQ--GFQMECRGRTELKGKGVEDTYWLV---GRVGFNKPIPKPPDLQPGAS 1080

  Fly   694 DH----LKLHPPTDYKLPKRK 710
            :|    .::.|....||.|.:
  Rat  1081 NHGISLQEIPPERRKKLEKAR 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:462453	59/336 (18%)
		CYCc	459..647	CDD:214485	111/190 (58%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594	11/30 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..552		11/43 (26%)
		PK_GC-2D	540..814	CDD:270945	53/307 (17%)
		HNOBA	<823..868	CDD:462234	19/44 (43%)
		CYCc	848..1039	CDD:214485	112/192 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1069..1108		9/33 (27%)